<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-671X</journal-id>
<journal-title><![CDATA[Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Medicina Interna]]></abbrev-journal-title>
<issn>0872-671X</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-671X2025000300020</article-id>
<article-id pub-id-type="doi">10.24950/rspmi.2653</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Sedação Paliativa: A Prática Atual de uma Equipa Intra-Hospitalar de Suporte em Cuidados Paliativos]]></article-title>
<article-title xml:lang="en"><![CDATA[Palliative Sedation: The Current Practice of a Hospital Palliative Care Team]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Araújo]]></surname>
<given-names><![CDATA[Margarida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rocha]]></surname>
<given-names><![CDATA[Céu]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[Hugo M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,ULS Braga Serviço de Medicina Interna ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,ULS Matosinhos Serviço de Medicina Interna Equipa Intra-Hospitalar de Suporte em Cuidados Paliativos]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<volume>32</volume>
<numero>3</numero>
<fpage>20</fpage>
<lpage>25</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-671X2025000300020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-671X2025000300020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-671X2025000300020&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução:  Em contextos de doença avançada, a sedação paliativa pode constituir uma intervenção necessária para o controlo de sintomas refratários às terapêuticas convencionais, proporcionando alívio do sofrimento.  Métodos:  Estudo de coorte retrospetivo que incluiu todos os doentes acompanhados por uma equipa intra-hospitalar de cuidados paliativos e submetidos a sedação paliativa ao longo do ano de 2022.  Resultados:  Dos 484 doentes acompanhados, 55 (11%) foram submetidos a sedação paliativa. A maioria era do sexo masculino (69%), com uma idade média de 70 anos. A patologia oncológica foi predominante (71%), enquanto 26% apre-sentavam doença não oncológica. O principal motivo para a sedação foi a inquietação terminal (47%), sendo o midazolam o fármaco mais frequentemente utilizado. O tempo mediano até fim de vida foi de 32,5 horas, com 65% dos doentes a falecerem em menos de 48 horas. A comparação entre doentes com patologia oncológica e não oncológica não revelou diferenças estatisticamente significativas relativamente à idade, dose máxima de midazolam, mortalidade nas primeiras 48 horas após o início da sedação ou sobrevida média. Verificou-se uma tendência para o uso de doses superiores de midazolam nos doentes com neoplasia do pulmão.  Conclusão:  A sedação paliativa é uma intervenção terapêutica reservada a situações em que não se obtém controlo sintomático com as estratégias convencionais. São necessá-rios mais estudos para comparar as intervenções de sedação paliativa em diferentes contextos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  In advanced disease contexts, palliative sedation can be a vital intervention for controlling symptoms that are resistant to conventional therapies, ultimately alleviating patient suffering.  Methods:  This retrospective cohort study examined all patients treated by an in-hospital palliative care team who received palliative sedation during the year 2022.  Results:  Of the 484 patients analyzed, 55 (11%) underwent palliative sedation. The majority were male (69%) with a mean age of 70 years. Oncology patients comprised 71% of the cohort, while 26% had non-oncological conditions. The primary indication for sedation was terminal restlessness (47%), with midazolam being the predominant medication used. The median time from sedation to end of life was 32.5 hours, with 65% of patients dying within 48 hours. No statistically significant differences were observed between oncological and non-on-cological patients regarding age, maximum midazolam dose, mortality within 48 hours, or median survival. There was a tendency to use higher doses of midazolam in patients with lung cancer.  Conclusion:  Palliative sedation serves as a therapeutic option for cases where symptomatic control remains unattainable through conventional methods. Ongoing research is necessary to evaluate the effects of palliative sedation across various care settings.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Deep Sedation]]></kwd>
<kwd lng="en"><![CDATA[Midazolam]]></kwd>
<kwd lng="en"><![CDATA[Palliative Care]]></kwd>
<kwd lng="en"><![CDATA[Terminal Care.]]></kwd>
<kwd lng="pt"><![CDATA[Cuidados Paliativos]]></kwd>
<kwd lng="pt"><![CDATA[Cuidados Terminais]]></kwd>
<kwd lng="pt"><![CDATA[Midazolam]]></kwd>
<kwd lng="pt"><![CDATA[Sedação Profunda.]]></kwd>
</kwd-group>
</article-meta>
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