<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-671X</journal-id>
<journal-title><![CDATA[Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Medicina Interna]]></abbrev-journal-title>
<issn>0872-671X</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-671X2025000300068</article-id>
<article-id pub-id-type="doi">10.24950/rspmi.2594</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Diagnosis Approach of Non-Hepatic Ascites: Peritoneal Mesothelioma]]></article-title>
<article-title xml:lang="pt"><![CDATA[Marcha Diagnóstica de Ascite não Hepática: Mesotelioma Peritoneal]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dias]]></surname>
<given-names><![CDATA[Diogo Duarte]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Louro]]></surname>
<given-names><![CDATA[Rita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vieira]]></surname>
<given-names><![CDATA[Ana Teresa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Amaro]]></surname>
<given-names><![CDATA[Margarida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escária]]></surname>
<given-names><![CDATA[Susana Dias]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidade Local de Saúde do Alentejo Central Hospital do Espírito Santo de Évora Serviço de Medicina]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Unidade Local de Saúde do Alentejo Central Hospital do Espírito Santo de Évora Serviço de Cardiologia]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Unidade Local de Saúde do Alentejo Central Hospital do Espírito Santo de Évora Serviço de Cirurgia Geral]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<volume>32</volume>
<numero>3</numero>
<fpage>68</fpage>
<lpage>71</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-671X2025000300068&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-671X2025000300068&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-671X2025000300068&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Malignant mesothelioma is a heterogeneous disease and peritoneal mesothelioma (PM) is an uncommon aetiology of non-hepatic ascites. Asbestos exposure is not directly associated with the disease progression and symptoms are non-specific, which delays the diagnosis. Radiology assessment and exploratory laparoscopy (with biopsy) are the main strategies to achieve and confirm PM diagnosis. Laparoscopy also plays an important role in staging. Due to its prevalence, few prospective trials or evidenced-based recommendations exist. Treatment options are often extrapolated from pleural mesothelioma. In this paper, the authors present an ascites diagnosis workup that leads to a PM. This case reflects the difficulty of the diagnosis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo O mesotelioma maligno constitui um grupo heterogéneo de neoplasias. O mesotelioma peritoneal (PM) em específico é uma etiologia pouco frequente de ascite não hepática. A exposição a asbestos não está diretamente relacionada com a progressão da doença e os sintomas são pouco específicos, o que pode atrasar o diagnóstico. Os principais meios diagnósticos para levantar a hipótese de PM e confirmá-la são a avaliação imagiológica e a laparoscopia exploradora (com biópsia). A laparoscopia tem também um importante papel no estadiamento da doença. Dada a sua baixa prevalência, existem poucos ensaios prospetivos e as recomendações têm baixo nível de evidência científica. As opções terapêuticas são frequentemente extrapoladas do mesotelioma pleural. Neste artigo, os autores apresentam a marcha diagnóstica de um caso de ascite, chegando ao diagnóstico de mesotelioma peritoneal.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Ascites/diagnosis]]></kwd>
<kwd lng="en"><![CDATA[Mesothelioma, Malignant/diagnosis]]></kwd>
<kwd lng="en"><![CDATA[Peritoneal Neoplasms/diagnosis.]]></kwd>
<kwd lng="pt"><![CDATA[Ascite/diagnóstico]]></kwd>
<kwd lng="pt"><![CDATA[Mesotelioma Maligno/diagnóstico]]></kwd>
<kwd lng="pt"><![CDATA[Neoplasias Peritoneais/diagnóstico.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kindler]]></surname>
<given-names><![CDATA[HL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Peritoneal Mesothelioma The Site of Origin Matters]]></article-title>
<source><![CDATA[Am Soc Clin Oncol Educ B]]></source>
<year>2013</year>
<volume>33</volume>
<page-range>182-8</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bhagwandin]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Labow]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Malignant peritoneal mesothelioma A review]]></article-title>
<source><![CDATA[Ann Transl Med]]></source>
<year>2017</year>
<volume>5</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>236</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Gao]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diffuse malignant peritoneal mesothelioma A review]]></article-title>
<source><![CDATA[Front Surg]]></source>
<year>2023</year>
<page-range>9</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Karpes]]></surname>
<given-names><![CDATA[JB]]></given-names>
</name>
<name>
<surname><![CDATA[Shamavonian]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Dewhurst]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Cheng]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Wijayawardana]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Ahmadi]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Malignant Peritoneal Mesothelioma An In-Depth and and Future Directions]]></article-title>
<source><![CDATA[Cancers]]></source>
<year>2023</year>
<volume>15</volume>
<page-range>4704</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García-Fadrique]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Mehta]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Mohamed]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Dayal]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Cecil]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Moran]]></surname>
<given-names><![CDATA[BJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical presentation, diagnosis, classification and management of peritoneal mesothelioma A review]]></article-title>
<source><![CDATA[J Gastrointest Oncol]]></source>
<year>2017</year>
<volume>8</volume>
<page-range>915-24</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kusamura]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kepenekian]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Villeneuve]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Lurvink]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Govaerts]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[De Hingh]]></surname>
<given-names><![CDATA[IH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Peritoneal mesothelioma PSOGI/EURACAN clinical practice guidelines for diagnosis, treatment and follow-up]]></article-title>
<source><![CDATA[Eur J Surg Oncol]]></source>
<year>2021</year>
<volume>47</volume>
<page-range>36-59</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Broeckx]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Pauwels]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Malignant peritoneal mesothelioma A review]]></article-title>
<source><![CDATA[Transl Lung Cancer Res]]></source>
<year>2018</year>
<volume>7</volume>
<page-range>537-42</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Popat]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Baas]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Faivre-Finn]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Girard]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Nicholson]]></surname>
<given-names><![CDATA[AG]]></given-names>
</name>
<name>
<surname><![CDATA[Nowak]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Malignant pleural mesothelioma ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upI]]></article-title>
<source><![CDATA[Ann Oncol]]></source>
<year>2022</year>
<volume>33</volume>
<page-range>129-42</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
