<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-8178</journal-id>
<journal-title><![CDATA[Jornal Português de Gastrenterologia ]]></journal-title>
<abbrev-journal-title><![CDATA[J Port Gastrenterol.]]></abbrev-journal-title>
<issn>0872-8178</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Gastrenterologia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-81782006000400002</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Linfoma não Hodgkin primário do fígado em doente com hepatite crónica a VHC]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gonçalves]]></surname>
<given-names><![CDATA[M. L.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rosa]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medeiros]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Viveiros]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Talhinhas]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mera]]></surname>
<given-names><![CDATA[J. Fernândez]]></given-names>
</name>
<xref ref-type="aff" rid="A03"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pina]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<xref ref-type="aff" rid="A04"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Queiroz]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Hospital Espírito Santo Unidade de Gastrenterologia ]]></institution>
<addr-line><![CDATA[Évora ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="A02">
<institution><![CDATA[,Hospital Espírito Santo Serviço de Imagiologia ]]></institution>
<addr-line><![CDATA[Évora ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="A03">
<institution><![CDATA[,Hospital Espírito Santo Serviço de Anatomia Patológica ]]></institution>
<addr-line><![CDATA[Évora ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="A04">
<institution><![CDATA[,Hospital Espírito Santo Unidade de Hematologia ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>07</month>
<year>2006</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>07</month>
<year>2006</year>
</pub-date>
<volume>13</volume>
<numero>4</numero>
<fpage>181</fpage>
<lpage>185</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-81782006000400002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-81782006000400002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-81782006000400002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Os autores apresentam o caso de um homem de 43 anos, com dor abdominal e sintomas constitucionais com 3 semanas de evolução, a quem se diagnosticou tumor solido do fígado e infecção crónica a Virus da Hepatite C (VHC). O tumor era um Linfoma não Hodgkin ( LNH) tipo B, primário. O doente foi submetido a quimioterapia e a tratamento para a hepatite crónica C, com boa resposta. Os autores discutem o caso e apresentam uma revisão da litera-tura sobre a associação VHC e LNH, em particular o LNH primário do fígado, e o eventual papel do virus na génese de linfomas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[The authors present the case of a 43 year old man, with abdominal pain and constitutional symptoms during 3 weeks, in whom was diagnosed a solid liver tumor and chronic hepatitis C. The tumor was a primary cell B non-Hodgkin Lymphoma (LNH). The patient was submitted to chemotherapy and treatment for hepatitis C with a favourable response. The authors discuss the case and present a review on the VHC and LNH association, the primary hepatic lymphoma in particular, and the possible role of the virus in lymphomagenesis.]]></p></abstract>
</article-meta>
</front><body><![CDATA[ <p><b>Linfoma      n&atilde;o Hodgkin prim&aacute;rio do f&iacute;gado em doente com hepatite      cr&oacute;nica a VHC</b></p>      <p>&nbsp;</p>         <p>M. L. Gon&ccedil;alves<sup><a href="#1">1</a><a name="top1"></a></sup>, I.    Rosa<sup><a href="#1">1</a><a name="top1"></a></sup>, I. Medeiros<sup><a href="#1">1</a><a name="top1"></a></sup>,    C. Viveiros<sup><a href="#1">1</a><a name="top1"></a></sup>, A. Talhinhas<sup><a href="#2">2</a><a name="top2"></a></sup>,    J. Fern&acirc;ndez Mera<sup><a href="#3">3</a><a name="top3"></a></sup>, F.    Pina<sup><a href="#4">4</a><a name="top4"></a></sup>, A. Queiroz<sup><a href="#1">1</a><a name="top1"></a></sup></p>      <p>&nbsp;</p>      <p><b><i>Resumo</i></b></p>       <p>Os autores apresentam o caso de um homem de 43 anos, com dor abdominal e sintomas constitucionais com 3 semanas de evolução, a quem se diagnosticou tumor solido do fígado e infecção crónica a Virus da Hepatite C (VHC). O tumor era um Linfoma não Hodgkin ( LNH) tipo B, primário. O doente foi submetido a quimioterapia e a tratamento para a hepatite crónica C, com boa resposta.</p>      <p>Os autores discutem o caso e apresentam uma revisão da litera-tura sobre a associação VHC e LNH, em particular o LNH primário do fígado, e o eventual papel do virus na génese de linfomas.</p>      <p>&nbsp;</p>      <p><b><i>Summary</i></b></p>       <p>The authors present the case of a 43 year old man, with abdominal pain and constitutional symptoms during 3 weeks, in whom was diagnosed a solid liver tumor and chronic hepatitis C. The tumor was a primary cell B non-Hodgkin Lymphoma (LNH). The patient was submitted to chemotherapy and treatment for hepatitis C with a favourable response.</p>      ]]></body>
<body><![CDATA[<p>The authors discuss the case and present a review on the VHC and LNH association, the primary hepatic lymphoma in particular, and the possible role of the virus in lymphomagenesis.</p>       <p>&nbsp;</p>      <p>Texto Completo disponível apenas em PDF</p>      <p>Full text only available in PDF format</p>      <p>&nbsp;</p>       <p>&nbsp;</p>      <p><b>Bibliografia</b></p>      <!-- ref --><p>1. Mazzaro C, Franzin F, Tulissi P, et al. Regression of monoclonal Bcell    expansion in patients affected by mixed cryoglobulinemia responsive to alpha-interferon    therapy. Cancer 1996; 77:2604-13.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000020&pid=S0872-8178200600040000200001&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><p>2. Patriarca F, Silvestri F, Fanin R, et al. Long&#8211;lasting complete remission of hepatitis C virus (HCV) infection and HCV-association immunocytoma with alpha-interferon treatment. Br J Haematol 2001; 112: 370-2.</p>      <p>3. Hermine O, Lefrere F, Bronowicki JP, et al. Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection. N Eng J Med 2002; 347: 89-94.</p>      ]]></body>
<body><![CDATA[<p>4. Levine AM, Shimoidara S, Lai MM. Treatment of HCV-related mantle-cell lymphoma with ribavirin and pegylated interferon alpha. N Eng J Med 2003; 349: 2078-9.</p>      <p>5. Mele A, Pulsoni A, Bianco E, et al. Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multi-center case-control study. Blood 2003; 102: 996-9.</p>      <p>6. Hausfater P, Cacoub P, Sterkers Y, et al. Hepatitis C virus infection and lymphoproliferative diseases: prospective study on 1576 patients in France. Am J Haematol 2001; 67: 168-71.</p>      <p>7. Turner N, Dusheiko G, Jones A. Hepatitis C and B-cell lymphoma. Annals of Oncology 2003; 14: 1341-5</p>      <p>8. Lei K. Primary non-Hodgkin`s lymphoma of the liver. Leuk Lymphoma 1998; 29: 293-9.</p>      <p>9. Page R, Romaguerra J, Osborne B, et al. Primary hepatic lymphoma - favourable outcome after combination chemotherapy. Cancer 2001; 92: 2023-9.</p>      <p>10. Bronowicki J, Bineau C, Feugier P, et al. Primary lymphoma of the liver: clinical-pathological features and relationship with HCV infection in French Patients. Hepatology 2003; 37: 781-7.</p>      <p>11. De Vita S, de Re V, Sansonno D, et al. Lack of HCV infection in malignant cells refutes the hypothesis of a direct transforming action of the virus in the pathogenesis of HCV-associated B-cell NHLs. Tumori 2002; 88: 400-6.</p>      <p>12. Pozzato G, Mazzaro C, Crovatto M, et al. Low grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia. Blood 1994;8 4: 3047-50.</p>      <p>13. Zuckerman E, Zuckerman T, Sahar D, et al. Bcl-2 and immunoglobulin gene rearrangement in patients with hepatitis C virus infection. Br J Haematol 2001; 112: 364-9.</p>      ]]></body>
<body><![CDATA[<p>14. Zuckerman E, Zuckerman T, Sahar D, et al. The effect of antiviral therapy on t(14;18) translocation ad immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection. Blood 2201; 97: 1555-9.</p>      <p>15. Wen-Kai W, Levy S. Hepatitis C Virus (HCV) and Lymphomagenesis. Leuk Lymphoma 2003; 44:1113-20.</p>      <p>16. Vento S, Cainelli F, Mirandola F. et al. Fulminant hepatitis on withdraw of chemotherapy in carriers of hepatitis C virus. Lancet 1996; 347: 92-3.</p>      <p>17. Tomita N, Kodama F, Takabayashi M, et al. Clinical features and outcome    in HCV-positive agressive non-Hodgkin`s lymphoma. Leuk Lymphoma 2003; 44: 1159-64.</p>     <p>&nbsp;</p>     <p>&nbsp;</p>        <p>&nbsp;</p>         <p><sup>(<a href="#top1">1</a><a name="1"></a>)</sup> Unidade de Gastrenterologia    do Hospital Espírito Santo, Évora, Portugal</p>        <p><sup>(<a href="#top2">2</a><a name="2"></a>)</sup> Serviço de Imagiologia do    Hospital Espírito Santo, Évora, Portugal</p>        <p><sup>(<a href="#top3">3</a><a name="3"></a>)</sup> Serviço de Anatomia Patológica    do Hospital Espírito Santo, Évora, Portugal</p>        ]]></body>
<body><![CDATA[<p><sup>(<a href="#top4">4</a><a name="4"></a>)</sup>Unidade de Hematologia do    Hospital Espírito Santo, Évora, Portugal</p>     <p><i>e-mail: </i><a href="mailto:lurdesgo@aeiou.pt">lurdesgo@aeiou.pt</a></p>     <p>&nbsp;</p>     <p>&nbsp;</p>       <p>&nbsp;</p>       <p align="right">Recebido para publicação: 21/01/2005</p>      <p align="right">Aceite para publicação: 27/04/2005</p>      <p>&nbsp;</p>        ]]></body><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mazzaro]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Franzin]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Tulissi]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Regression of monoclonal Bcell expansion in patients affected by mixed cryoglobulinemia responsive to alpha-interferon therapy.]]></article-title>
<source><![CDATA[Cancer]]></source>
<year>1996</year>
<volume>77</volume>
<page-range>2604-13</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
