<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-8178</journal-id>
<journal-title><![CDATA[Jornal Português de Gastrenterologia ]]></journal-title>
<abbrev-journal-title><![CDATA[J Port Gastrenterol.]]></abbrev-journal-title>
<issn>0872-8178</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Gastrenterologia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-81782007000100007</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[A Parábola do destino na carcinogénese colo-rectal esporádica]]></article-title>
<article-title xml:lang="en"><![CDATA[The parable of destiny in sporadic colorectal carcinogenesis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fidalgo]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soares]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rosa]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<xref ref-type="aff" rid="A03"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[J. P.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[A. G.]]></given-names>
</name>
<xref ref-type="aff" rid="A04"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leitão]]></surname>
<given-names><![CDATA[C. Nobre]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Instituto Português de Oncologia de Lisboa Francisco Gentil Serviço de Gastrenterologia ]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="A02">
<institution><![CDATA[,Hospital Geral de Santo António Serviço de Gastrenterologia ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="A03">
<institution><![CDATA[,Hospital do Espírito Santo Serviço de Gastrenterologia ]]></institution>
<addr-line><![CDATA[Évora ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="A04">
<institution><![CDATA[,Universidade Nova de Lisboa Faculdade de Ciências Médicas Departamento de Bioestatística e Informática]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>01</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>01</month>
<year>2007</year>
</pub-date>
<volume>14</volume>
<numero>1</numero>
<fpage>34</fpage>
<lpage>36</lpage>
<copyright-statement/>
<copyright-year/>
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</front><body><![CDATA[ <p><b>A Par&aacute;bola do <i>destino</i> na carcinog&eacute;nese colo-rectal    espor&aacute;dica</b></p>     <p><b>The parable of destiny in sporadic colorectal carcinogenesis</b></p>     <p>&nbsp;</p>     <p><a name="top1"></a>P. Fidalgo<sup><a href="#1">1</a></sup>, J. Soares<sup><a href="#2">2</a></sup>,    I. Rosa<sup><a href="#3">3</a></sup>, J. P. Silva<sup><a href="#1">1</a></sup>,    A. G. Oliveira<sup><a href="#4">4</a></sup>, C. Nobre Leit&atilde;o<sup><a href="#1">1</a></sup></p>      <p>&nbsp;</p>     <p>&nbsp;</p>     <p>Texto Completo disponível apenas em    PDF</p>      <p>Full text only available in PDF format</p>     <p>&nbsp;</p>     <p>&nbsp;</p>      ]]></body>
<body><![CDATA[<p><b>BIBLIOGRAFIA</b></p>      <!-- ref --><p>1. Lengauer C, Kinzler KW, Vogelstein B. Genetic Instabilities in human cancers. Nature, 1998; 396: 643-9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000014&pid=S0872-8178200700010000700001&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><p>2. Imrie Lakatos. The demarcation problem. <a href="http://www.lse.ac.uk/collections/lakatos/scienceandpseudoscience.htm" target="_blank">www.lse.ac.uk/collections/lakatos/scienceandpseudoscience.htm</a></p>      <p>3. Georg Lukács. História e Consciência de Classe. 1920. Edição Brasileira, Rio de Janeiro</p>      <p>4. Frank SA. Amultistage theory of age-specific acceleration in human mortality.    BMC biology 2004, 2: 16. Disponível em <a href="http://www.biomedcentral.com/1741-7007/2/16" target="_blank">www.biomedcentral.com/1741-7007/2/16</a></p>      <p>5. Spirio LN, Samowitz W, Roberston J, Robertson M, Burt RW, Leppert M, White R. Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps. Nat Genet. 1998; 20: 385-8.</p>      <p>6. Nowak M, Michor F, Komarova N, Iwasa Y. Evolutionary dynamics of tumor supressor gene inactivation. PNAS 2004; 101: 10635-8.</p>      <p>7. Frank SA. Development predisposition to câncer. Nature 2003; 422: 494.</p>      <p>&nbsp;</p>      <p>&nbsp;</p>      ]]></body>
<body><![CDATA[<p><sup><a name="1"></a>(<a href="#top1">1</a>)</sup> Serviço de Gastrenterologia,    Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E., Lisboa,    Portugal.</p>      <p><sup><a name="2"></a>(<a href="#top1">2</a>)</sup> Serviço de Gastrenterologia,    Hospital Geral de Santo António, Porto, Portugal.</p>      <p><sup><a name="3"></a>(<a href="#top1">3</a>)</sup> Serviço de Gastrenterologia,    Hospital do Espírito Santo, Évora, Portugal.</p>      <p><sup><a name="4"></a>(<a href="#top1">4</a>)</sup> Departamento de Bioestatística    e Informática, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa,    Portugal.</p>      <p>&nbsp;</p>      <p></p>     <p align="right"><i>Recebido para publicação: 07/11/2006</i></p>     <p align="right" class=MsoNormal style='mso-layout-grid-align:none;text-autospace:none'><i>Aceite    para publicação: 10/11/2006</i></p>       ]]></body><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lengauer]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Kinzler]]></surname>
<given-names><![CDATA[KW]]></given-names>
</name>
<name>
<surname><![CDATA[Vogelstein]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Genetic Instabilities in human cancers]]></article-title>
<source><![CDATA[Nature]]></source>
<year>1998</year>
<volume>396</volume>
<page-range>643-9</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
