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<front>
<journal-meta>
<journal-id>0872-8178</journal-id>
<journal-title><![CDATA[Jornal Português de Gastrenterologia ]]></journal-title>
<abbrev-journal-title><![CDATA[J Port Gastrenterol.]]></abbrev-journal-title>
<issn>0872-8178</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Gastrenterologia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-81782007000200008</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Terapêutica médica]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Portela]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Universidade de Coimbra Hospitais da Universidade de Coimbra Serviço de Gastrenterologia]]></institution>
<addr-line><![CDATA[Coimbra ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2007</year>
</pub-date>
<volume>14</volume>
<numero>2</numero>
<fpage>84</fpage>
<lpage>88</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-81782007000200008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-81782007000200008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-81782007000200008&amp;lng=en&amp;nrm=iso"></self-uri></article-meta>
</front><body><![CDATA[ <p><b>Terap&ecirc;utica m&eacute;dica</b></p>      <p>F. Portela</p>     <p>Servi&ccedil;o de Gastrenterologia, Hospitais da Universidade de Coimbra, Coimbra,    Portugal.</p>     <p>&nbsp;</p>     <p>&nbsp;</p>      <p>Texto Completo disponível apenas em PDF</p>      <p>Full text only available in PDF format</p>     <p>&nbsp;</p>     <p>&nbsp;</p>     <p><b>BIBLIOGRAFIA</b></p>     ]]></body>
<body><![CDATA[<!-- ref --><p> 1. Stange EF. The case against using 5-aminosalicyclates in Crohn's disease:    con. Inflamm Bowel Dis. 2005 Jun;11(6):613-5. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000013&pid=S0872-8178200700020000800001&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><p>2. Hanauer SB. The case for using 5-aminosalicyclates in Crohn's disease: pro.    Inflamm Bowel Dis. 2005 Jun;11(6):609-12. </p>     <p>3. Summers RW, Switz DM, Sessions JT, et al. National co-operative Crohn's    disease study group: results of drug treatment. Gastroenterology 1979;77:847-69.  </p>     <p>4. Malchow H, Ewe K, Brandes JW, et al. European co-operative Crohn's disease    study (ECCDS): results of drug treatment. Gastroenterology 1984;86:249-66. </p>     <p>5. Tremaine WJ, Schroeder KW, Harrison JM, et al. A randomized, doubleblind,    placebo-controlled trial of the oral mesalamine (5- ASA) preparation, Asacol,    in the treatment of symptomatic Crohn's colitis and ileocolitis. J Clin Gastroenterol    1994;19:278-82. </p>     <p>6. Singleton JW, Hanauer SB, Gitnick GL, et al. Mesalamine capsules for the    treatment of active Crohn's disease: results of a 16- week trial. Gastroenterology    1993;104:1293-301. </p>     <p>7. Hanauer SB, Stro&uml;mberg U. Oral Pentasa in the treatment of active Crohn's    disease: a meta-analysis of double-blind, placebo-controlled trials. Clin Gastroenterol    Hepatol 2004;2:379-88 </p>     <p>8. Faubion WA Jr, Loftus EV Jr, Harmsen WS, Zinsmeister AR, Sandborn WJ. The    natural history of corticosteroid therapy for inflammatory bowel disease: a    population-based study. Gastroenterology. 2001 Aug;121(2):255-60. </p>     <p>9. Steinhart AH, Hemphill D, Greenberg GR. Sulfasalazine and mesalazine for    the maintenance therapy of Crohn's disease: a meta-analysis. Am J Gastroenterol    1994;89:2116-24. </p>     <p>10. Messori A, Brignola C, Trallori, et al. Effectiveness of 5-aminosalicylic    acid for maintaining remission in patients with Crohn's disease: a meta-analysis.    Am J Gastroenterol 1994;89:692-8. </p>     ]]></body>
<body><![CDATA[<p>11. Camma C, Giunta M, Rosselli M, et al. Mesalamine in the maintenance treatment    of Crohn's disease: a meta-analysis adjusted for confounding variables. Gastroenterology    1997;113:1465-73. </p>     <p>12. Akobeng AK, Gardener E. Oral 5-aminosalicylic acid for maintenance of medically-induced    remission in Crohn's disease. Cochrane Library, Issue1 Chichester, Wiley, 2005.  </p>     <p>13. Lochs H, Mayer M, Fleig WE, Mortensen PB, Bauer P, Genser D, et al. Prophylaxis    of postoperative relapse in Crohn's disease with mesalamine: European Cooperative    Crohn's Disease Study VI. Gastroenterology. 2000 Feb;118(2):264-73. </p>     <p>14. R Caprilli, M A Gassull, J C Escher, G Moser, P Munkholm, A Forbes, et    al, for the European Crohn's and Colitis Organisation (ECCO). European evidence    based consensus on the diagnosis and management of Crohn's disease: special    situations. Gut 2006;55(Suppl I):i36-i58. </p>     <p>15. Greenberg GR, Feagan BG, Martin F, Martin F, Sutherland LR, Thomson AB,    et al. Oral budesonide for active Crohn's disease. Canadian Inflammatory Bowel    Disease Study Group. N Engl J Med 1994;331:836-841. </p>     <p>16. Thomsen OO, Cortot A, Jewel D, Wright JP, Winter T, Veloso FT, et al. A    comparison of budesonide and mesalamine for active Crohn's disease. International    Budesonide-Mesalamine Study Group. N Engl J Med 1998;339: 370-374. </p>     <p>17. Kane SV, Schoenfeld P, Sandborn WJ, Tremaine W, Hofer T, Feagan BG. The    effectiveness of budesonide therapy for Crohn's disease. Aliment Pharmacol Ther    2002;16:1509 - 1517.</p>     <p>18. Singleton JW, Law DH, Kelley ML Jr, Mekhjian HS, Sturdevant RA. National    Cooperative Crohn's Disease Study: adverse reactions to study drugs. Gastroenterology    1979;77: 870-882 </p>     <p>19. Travis SPL, Stange EF, Le&acute;mann M, Resland TO, Chowers Y, Forbes A,    et al, for the European Crohn's and Colitis Organisation (ECCO).European evidence    based consensus on the diagnosis and management of Crohn's disease: current    management Gut 2006; 55(Suppl I): 116-135. </p>     <p>20. Lemann M, Mary JY, Colombel JF, Duclos B, Soule JC, Lerebours E, et al,    Groupe D'Etude Therapeutique des Affections Inflammatoires du Tube Digestif.    A randomized, double blind, controlled withdrawal trial in Crohn's disease patients    in long-term remission on azathioprine. Gastroenterology. 2005 Jun; 128 (7)    : 1812-8. </p>     ]]></body>
<body><![CDATA[<p>21. Present DH, Korelitz BI, Wisch N, Glass JL, Sachar DB, Pasternack BS. Treatment    of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind    study. N Engl J Med 1980; 302: 981-987. </p>     <p>22. Ewe K, Press AG, Singe CC, Stufler M, Ueberschaer B, Hommel G, Meyer zum    Buschenfelde KH. Azathioprine combined with prednisolone or monotherapy with    prednisolone in active Crohn's disease. Gastroenterology 1993; 105: 367-372.  </p>     <p>23. Willoughby JM, Beckett J, Kumar PJ, Dawson AM. Controlled trial of azathioprine    in Crohn's disease. Lancet 1971; 2: 944-947. </p>     <p>24. Candy S, Wright J, Gerber M, Adams G, Gerig M, Goodman R. A controlled    double blind study of azathioprine in the management Terap&ecirc;utica M&eacute;dicaof    Crohn's disease. Gut 1995; 37: 674-678. </p>     <p>25. Rosenberg JL, Levin B, Wall AJ, Kirsner JB. A controlled trial of azathioprine    in Crohn's disease. Am J Dig Dis 1975; 20: 721-726. </p>     <p>26. Lichtenstein GR, Abreu MT, Cohen R, Tremaine W. American Gastroenterological    Association. American Gastroenterological Association Institute technical review    on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease.    Gastroenterology. 2006 Mar;130(3): 940-87. </p>     <p>27. Hanauer SB, Korelitz BI, Rutgeerts P, Peppercorn MA, Thisted RA, Cohen    RD, Present DH. Postoperative maintenance of Crohn's disease remission with    6-mercaptopurine, mesalamine, or placebo: a 2-year trial. Gastroenterology 2004;    127: 723-729. </p>     <p>28. Ardizzone S, Maconi G, Sampietro GM, Russo A, Radice E, Colombo E, et al.    Azathioprine and mesalamine for prevention of relapse after conservative surgery    for Crohn's disease. Gastroenterology 2004;127: 730-740. </p>     <p>29. Feagan BG, Rochon J, Fedorak RN, Irvine JE, Wild G, Sutherland L, et al.    Methotrexate for the treatment of Crohn's disease. The North American Crohn's    Study Group Investigators. N Engl J Med 1995; 332: 292-297. </p>     <p>30. Feagan BG, Fedorak RN, Irvine EJ, Sutherland L, Steinhart AH, Greenberg    GR, et al. A comparison of methotrexate with placebo for the maintenance of    remission in Crohn's disease. North American Crohn's Study Group Investigators.    N Engl J Med 2000; 342: 1627-1632. </p>     ]]></body>
<body><![CDATA[<p>31. Weinblatt ME. Methotrexate for chronic disease in adults. N Engl J Med    1995; 332: 330-331. </p>     <p>32. Targan SR, Hanauer SB, van Deventer SJ, Mayer L, Present DH, Braakman T,    et al. A shortterm study of chimeric monoclonal antibody cA2 to tumor necrosis    factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J    Med 1997; 337: 1029-1035. </p>     <p>33. Present DH, Rutgeerts P, Targan S, Hanauer SB, Mayer L, van Hogezand RA,    et al. Infliximab for the treatment of fistulas in patients with Crohn's disease.    N Engl J Med 1999; 340: 1398- 1405. </p>     <p>34. Rutgeerts P, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel    JF, et al. Comparison of scheduled and episodic treatment strategies of infliximab    in Crohn's disease. Gastroenterology 2004; 126: 402-413. </p>     <p>35. Baert F, Noman M, Vermeire S, Van Assche G, D' Haens G, Carbonez A, Rutgeerts    P. Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's    disease. N Engl J Med 2003; 348: 601-608. </p>     <p>36. Travis SPL, Stange EF, Le&acute;mann M, Resland TO, Chowers Y, Forbes A,    et al, for the European Crohn's and Colitis Organisation (ECCO) European evidence    based consensus on the diagnosis and management of Crohn's disease: current    management Gut 2006;55(Suppl I):116-135. </p>     <p>37. Panaccione R, Fedorak RN, Aumais G, Bernstein CN, Bitton A, Croitoru K,    et al. Canadian Association of Gastroenterology. Canadian Association of Gastroenterology    Clinical Practice Guidelines: the use of infliximab in Crohn's disease. Can    J Gastroenterol. 2004 Aug;18(8): 503-8. </p>     <p>38. Sands BE, Anderson FH, Bernstein CN, Chey WY, Feagan BG, Fedorak RN, et    al. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J    Med. 2004 Feb 26; 350(9): 876-85.</p>     <p> 39. Sartor RB. Episodic retreatment versus scheduled maintenance therapy of    Crohn's disease with infliximab: not so far apart. Gastroenterology. 2004 Feb;126(2):    598-601. </p>     <p>40. Lichtenstein GR, Feagan BG, Cohen RD, Salzberg BA, Diamond RH, Chen DM,    et al. Serious infections and mortality in association with therapies for Crohn's    disease: TREAT registry. Clin Gastroenterol Hepatol. 2006 May;4(5):621-30. </p>     ]]></body>
<body><![CDATA[<p>41. FDA Board Document. Update on the TNF-alpha blocking agent; 2003. Available    at: FDA Board Document. SAFETY OF TNF BLOCKING AGENTS. <a href="http://www.fda.gov/ohrms/dockets/ac/03/briefing/%203930B1_01_B-TNF.Briefing.htm" target="_blank">www.fda.gov/ohrms/dockets/ac/03/briefing/    3930B1_01_B-TNF.Briefing.htm</a>.</p>     <p> 42. S. Schreiber, M. Khaliq-Kareemi, I. Lawrance, S. Hanauer, J. McColm, R.    Bloomfield, W. Sandborn. Certolizumab Pegol, a Humanized anti- TNF Pegylated    FAB' Fragment, is safe and effective in the maintenance of response and remission    following induction in active Crohn's disease: A phase III study (PRECISE) Gut    2005; 54 (Suppl VII) A82 </p>     <p>43. Hanauer SB, Sandborn WJ, Rutgeerts P, Fedorak RN, Lukas M, MacIntosh D,    et al. Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in    Crohn's disease: the CLASSIC-I trial. Gastroenterology. 2006 Feb;130(2): 323-33;    quiz 591. </p>     <p>44. J. Colombel, W.J. Sandborn, P. Rutgeerts, R.A. Enns, S.B. Hanauer, R. Panaccione,    et al. Adalimumab maintains clinical response and remission in patients with    active Crohn's disease: results of the CHARM trial. Gut 2006; 55 (Suppl V) A123  </p>     <p>45. Sandborn WJ, Colombel JF, Enns R, et al. Natalizumab induction and maintenance    therapy for Crohn's disease. N Engl J Med 2005; 353: 1912-25. </p>     <p>46. Gert Van Assche, Marc Van Ranst, Raf Sciot, B&eacute;n&eacute;dicte Dubois,    S&eacute;verine Vermeire, Maja Noman, et al. Progressive Multifocal Leukoencephalopathy    after Natalizumab Therapy for Crohn's Disease. N Engl J Med 2005; 353: 362-8.</p>      ]]></body><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stange]]></surname>
<given-names><![CDATA[EF.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[The case against using 5-aminosalicyclates in Crohn's disease: con.]]></article-title>
<source><![CDATA[Inflamm Bowel Dis.]]></source>
<year>2005</year>
<month> J</month>
<day>un</day>
<volume>11</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>613-5</page-range></nlm-citation>
</ref>
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