<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-8178</journal-id>
<journal-title><![CDATA[Jornal Português de Gastrenterologia ]]></journal-title>
<abbrev-journal-title><![CDATA[J Port Gastrenterol.]]></abbrev-journal-title>
<issn>0872-8178</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Gastrenterologia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-81782009000400002</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Caracterização da Hemorragia Digestiva Aguda Severa por Angiodisplasia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[S. Sousa]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romãozinho]]></surname>
<given-names><![CDATA[J. M.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Amaro]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leitão]]></surname>
<given-names><![CDATA[M. Correia]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Hospitais da Universidade de Coimbra Unidade de Cuidados Intensivos de Gastrenterologia ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2009</year>
</pub-date>
<volume>16</volume>
<numero>4</numero>
<fpage>142</fpage>
<lpage>148</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-81782009000400002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-81782009000400002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-81782009000400002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[INTRODUÇÃO: As angiodisplasias são causas raras de hemorragia digestiva aguda. A natureza intermitente da hemorragia e a extensão de tubo digestivo envolvido colocam desafios particulares. OBJECTIVOS: Caracterizar as hemorragias digestivas agudas severas por angiodisplasia. DOENTES E MÉTODOS: Análise retrospectiva das hemorragias digestivas agudas por angiodisplasia admitidas na Unidade de Cuidados Intensivos de Gastrenterologia (UCIGE) dos Hospitais da Universidade de Coimbra, entre 1992 e 2008. RESULTADOS: Incluídos 21 doentes, representando 0,54% das admissões no período considerado. Registou-se predomínio do sexo masculino e idade média de 74 anos (42-92). Todos os doentes apresentavam co-morbilidades e 40% tomavam antiagregantes plaquetares ou anticoagulantes. A hemorragia foi proximal à ampola de Vater em 62% dos casos. Efectuou-se hemostase endoscópica em 18 doentes, que foi eficaz em todos eles. Outras terapêuticas menos utilizadas incluíram a embolização e enterectomia. Não ocorreu recidiva hemorrágica durante os internamentos. A mortalidade cifrou-se em 4,7%, correspondendo a um doente sujeito a laparotomia, falecido no pós-operatório imediato. CONCLUSÕES: A hemorragia digestiva aguda severa por angiodisplasia foi um evento raro na UCIGE. A endoscopia teve um papel fundamental no diagnóstico e na terapêutica. Os resultados corroboram a pertinência da admissão destes casos numa UCIGE, tendo em conta, nomeadamente, a importante comorbilidade que os caracteriza.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[INTRODUCTION: Angiodysplasias are rare causes of acute gastrointestinal bleeding. Brisk bleeding and extension of the bowel involved are associated with specific challenges. AIM: Descrption of the main features of gastrointestinal bleeding caused by angiodysplasia. PATIENTS AND METHODS: Retrospective analysis of gastrointestinal bleeding episodes caused by angiodysplasia in patients admitted to the Gastroenterology Intensive Care Unit of Hospitais da Universidade de Coimbra, between 1992 and 2008. RESULTS: Twenty-one patients were included, representing 0,54% of all admissions in the unit during the mentioned period. Most patients were men with an average age of 74 years (42-92). All patients had comorbidities; 40% were taking antiplatelet or anticoagulant drugs. Bleeding was proximal to the ampulla of Vater in 62% of the patients. Endoscopic hemostasis was performed and was successful in 18 patients. Other therapies rarely used were angiographic embolization and segmental enterectomy. There was no recurrent bleeding during hospital stay. CONCLUSIONS: Severe gastrointestinal bleeding caused by angiodysplasia was a rare event in the unit. Endoscopy had a major role both in diagnosis and therapy. The results underline the importance of criterious admission in the Gastroenterology Intensive Care Unit, attending to the comorbidities that characterize these patients.]]></p></abstract>
</article-meta>
</front><body><![CDATA[ <p><b>Caracterização da Hemorragia Digestiva Aguda Severa por Angiodisplasia</b></p>      <p>&nbsp;</p>      <p>S. Sousa Fernandes<sup><a href="#1">1</a></sup>, M. Ferreira<sup><a href="#1">1</a></sup>,    J. M. Romãozinho<sup><a href="#1">1</a></sup>, M. Ferreira<sup><a href="#1">1</a></sup>,    P. Amaro<sup><a href="#1">1</a></sup>, M. Correia Leitão<sup><a name="top1"></a><a href="#1">1</a></sup></p>      <p>&nbsp;</p>     <p><b>&nbsp;</b></p>      <p><b>RESUMO</b></p>      <p>INTRODUÇÃO: As angiodisplasias são causas raras de hemorragia digestiva aguda.    A natureza intermitente da hemorragia e a extensão de tubo digestivo envolvido    colocam desafios particulares. OBJECTIVOS: Caracterizar  as hemorragias digestivas    agudas severas por angiodisplasia. DOENTES E MÉTODOS: Análise retrospectiva    das hemorragias digestivas agudas por angiodisplasia  admitidas na Unidade de    Cuidados Intensivos de Gastrenterologia (UCIGE) dos Hospitais da Universidade    de Coimbra, entre 1992 e 2008. RESULTADOS:  Incluídos 21 doentes, representando    0,54% das admissões no período considerado. Registou-se predomínio do sexo masculino    e idade média de 74 anos (42-92). Todos os doentes apresentavam co-morbilidades    e 40% tomavam antiagregantes plaquetares ou anticoagulantes. A hemorragia foi    proximal à ampola de Vater em 62% dos casos. Efectuou-se hemostase endoscópica    em 18 doentes, que foi eficaz em todos eles. Outras terapêuticas menos utilizadas    incluíram a embolização e enterectomia. Não ocorreu recidiva hemorrágica durante    os internamentos. A mortalidade cifrou-se em 4,7%, correspondendo a um doente    sujeito a laparotomia, falecido no pós-operatório imediato. CONCLUSÕES: A hemorragia    digestiva aguda severa por angiodisplasia foi um evento raro na UCIGE. A endoscopia    teve um papel fundamental no diagnóstico e na terapêutica. Os resultados corroboram    a pertinência da admissão destes casos numa UCIGE, tendo em conta, nomeadamente,    a importante comorbilidade que os caracteriza.</p>      <p>&nbsp;</p>     <p>&nbsp;</p>      <p><b>SUMMARY</b></p>      ]]></body>
<body><![CDATA[<p>INTRODUCTION: Angiodysplasias are rare causes of acute gastrointestinal bleeding.    Brisk bleeding and extension of the bowel involved are associated with specific    challenges. AIM: Descrption of the main features of gastrointestinal bleeding    caused by angiodysplasia. PATIENTS AND METHODS: Retrospective analysis of gastrointestinal    bleeding episodes caused by angiodysplasia in patients admitted to the Gastroenterology    Intensive Care Unit of Hospitais da Universidade de Coimbra, between 1992 and    2008. RESULTS: Twenty-one patients were included, representing 0,54% of all    admissions in the unit during the mentioned period. Most patients were men with    an average age of 74 years (42-92). All patients had comorbidities; 40% were    taking antiplatelet or anticoagulant drugs. Bleeding was proximal to the ampulla    of Vater in 62% of the patients. Endoscopic hemostasis was performed and was    successful in 18 patients. Other therapies rarely used were angiographic embolization    and segmental enterectomy. There was no recurrent bleeding during hospital stay.    CONCLUSIONS: Severe gastrointestinal bleeding caused by angiodysplasia was a    rare event in the unit. Endoscopy had a major role both in diagnosis and therapy.    The results underline the importance of criterious admission in the Gastroenterology    Intensive Care Unit, attending to the comorbidities that characterize these    patients.</p>      <p>&nbsp;</p>      <p>&nbsp;</p>      <p>Texto Completo disponível apenas em PDF</p>      <p>Full text only available in PDF format</p>      <p>&nbsp;</p>      <p>&nbsp;</p>      <p><b>Bibliografia</b></p>      <!-- ref --><p>1. Regula J, Wronska E, Pachlewski J. Vascular lesions of the gastrointestinal    tract. Best Pract &amp; Res Gastroenterology, 2008; 22(2):313.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000021&pid=S0872-8178200900040000200001&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><p>2. Boley SJ, Sammartano RJ, Adams A. On the nature and etiology of vascular ectasias of the cólon: degenerative lesions of ageing. Gastroenterology, 1977; 72:650.</p>      ]]></body>
<body><![CDATA[<p>3. Danesh B, Spiliadis C, Williams C, Zambartas C. Angiodysplasia — an uncommon cause of colonic bleeding: colonoscopic evaluation of 1,050 patients with rectal bleeding and anaemia. International Journal of Colorectal Disease, 1987; 2(4): 1832.</p>      <p>4. Angiodisplasia of the gastrointestinal tract. Am J Gastro, 1993; 88(6): 807-18.</p>      <p>5. Foutch PG. Angiodysplasia of the gastrointestinal tract. Am J Gastro, 1993; 88: 807.</p>      <p>6. Bleeging gastrointestinal angiodysplasia:our experience and review of the literature. Ann Ital Med Int, 2004; 19(2): 122.</p>      <p>7. Heyde EC. Gastrointestinal bleeding in aortic stenosis. N Engl J Med, 1958; 259: 196.</p>      <p>8. Sucker C. The Heyde syndrome: Proposal for a unifying concept explaining the association of aortic valve stenosis, gastrointestinal angiodysplasia and bleeding. International Journal of Cardiology, 2007; 115(1): 77-78.</p>      <p>9. BouleySJ, Brandt LJ. Vascular ectasias of the colon. Dig Dis Sci, 1986; 31: 26.</p>      <p>10. Strate LL. Lower GI bleeding: epidemiology and diagnosis. Gastroenterol Clin North Am, 2005; 34(4): 643-64.</p>      <p>11. Romãozinho JM, Ed. Intensive Care In Gastroenterology. Coimbra 2007: 137-155.</p>      <p>12. Cappell MS, Gupta A. Changing epidemiology of gastrointestinal angiodysplasia with increasing recogition of clinically milder cases: angiodysplasia tend to produce mild chronic gastrointestinal bleeding in a study of 47 consecutive patients admitted from 1980-1989. Am J Gastro, 1992; 87(2): 201.</p>      ]]></body>
<body><![CDATA[<p>13. Manning-Dimmitt L, Dimmitt S, Wilson G. Diagnosis of gastrointestinal bleeding in adults. Am Fam Physician, 2005; 71:1339.</p>      <p>14. Sotoudehmanesh R, Ali Asgari A, Ansari R, Nouraie M. Endoscopic findings in end-stage renal disease. Endoscopy, 2003; 35(6): 502.</p>      <p>15. Abou-Saif A, Lewis JH. Gastrointestinal and hepatic disorders in end-stage renal disease and renal transplant recipients. Adv Ren Replace Ther, 2000; 7(3): 220.</p>      <p>16. Wong Kee Song LM, Baron TH. Endoscopic Management of Acute Lower Gastrointestinal Bleeding. Am J Gastroenterol, 2008; 103:1881.</p>      <p>17. Fogel R, Valdivia E. Bleeding Angiodysplasia of the Colon. Curr Treat Options Gastroenterol, 2002; 5(3): 225.</p>      <p>18. Pavey DA, Craig PI. Endoscopic therapy for upper-GI vascular ectasias. Gastrointest Endosc, 2004; 59(2): 233.</p>      <p>19. Karagiannis S, Goulas S, Kosmadakis G, Galanis P, Arvanitis D, Boletis J, Georgiou E, Mavrogiannis C. Wireless capsule endoscopy in the investigation of patients with chronic renal failure and obscure gastrointestinal bleeding (preliminary data). World J Gastroenterol, 2006; 12(32): 5182.</p>      <p>20. Raju GS, Gerson L, Das A, Lewis B; American Gastroenterological Association. American Gastroenterology Association Institute Technical review on obscure gastrointestinal bleeding. Gastroenterollogy, 2007; 133(5): 1697</p>      <p>21. Pennazio M. Bleeding update. Gastrointest Endosc Clin North Am, 2006; 16: 251</p>      <p>22. Longstreth GF. Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study. Am J Gastroenterol, 1997; 92: 419</p>      ]]></body>
<body><![CDATA[<p>23. Gutierrez C, Mariano M, Vander Laan T, Wang A, Faddis DM, Stain SC. The use of technetium-labeled erythrocyte scintigraphy in the evaluation and treatment of lower gastrointestinal hemorrhage. Am Surg, 1998; 64: 989.</p>      <p>24. Biandrate F, Piccolini M, Francia L, Rosa C, Battaglia A, Pandolfi U. Bleeding small bowel angiodysplasia: unusual form of conservative treatment. Chir Ital, 2002; 55(3): 475.</p>      <p>25. Lau WY, Chu KW, Yuen WK, Poon GP, Li AK. Bleeding angiodysplasia of the gastrointestinal tract. Aust N Z J Surg, 1992; 62(5): 344.</p>      <p>26. Olmos J, Marcolongo M, Pogorelsky V, Herrera L, Federico T, Dávolos J. Long-term outcome of argon plasma ablation therapy for bleeding in 100 consecutive patients with colonic angiodysplasia. Dis Colon Rectum, 2006; 49(10): 1507.</p>      <p>27. Olmos JA, Marcolongo M, Pogorelsky V, Varela E, Dávolos JR. Argon plasma coagulation for prevention of recurrent bleeding from GI angiodysplasias. Gastrointest Endosc, 2004; 60(6): 881.</p>      <p>28. Suzuki N, Arebi N, Saunders BP. A novel method of treating colonic angiodysplasia, 2006; 64(3): 424.</p>      <p>29. Molina-Infante J, Perez-Gallardo B. Gonzalez-Garcia G. Octeotride LAR for severe obscure-overt gastrointestinal haemorrhage in high-risk patients on anticoagulation therapy. Gut, 2007; 56: 447.</p>      <p>30. Bauditz J, Lochs H, Voderholzer W. Macroscopic appearance of intestinal angiodysplasia under antiangiogenic treatment with thalidomide. Endoscopy, 2006; 38: 1036.</p>      <p>31. Junquera F, Feu F, Papo M. A multicenter, randomized, clinical trial of hormonal therapy in prevention of rebleeding from gastrointestinal angiodysplasia. Gastroenterology 2001; 121:1073.</p>      <p>&nbsp;</p>     ]]></body>
<body><![CDATA[<p>&nbsp;</p>     <p><sup><a name="1"></a><a href="#top1">1</a></sup>Unidade de Cuidados Intensivos    de Gastrenterologia, Hospitais da Universidade de Coimbra, Portugal</p>     <p>&nbsp;</p>     <p><b>Correspondência</b>:</p>     <p>Sónia Sousa Fernandes</p>     <p>Serviço de Gastrenterologia e Hepatologia do Centro Hospitalar de Vila Nova    de Gaia</p>     <p>Rua Conceição Fernandes</p>     <p>4432-502 Vila Nova de Gaia, Portugal</p>     <p>Telefone: 227 865 100</p>     <p>Fax: 227 836 583</p>     ]]></body>
<body><![CDATA[<p>Email: <a href="mailto:sonia.sousa.fernandes@gmail.com">sonia.sousa.fernandes@gmail.com</a></p>      <p align="right"><i>Recebido para publicação: 22/10/2008</i></p>     <p align="right"><i>Aceite para publicação: 21/04/2009</i></p>        ]]></body><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Regula]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Wronska]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Pachlewski]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Vascular lesions of the gastrointestinal tract.]]></article-title>
<source><![CDATA[Best Pract & Res Gastroenterology]]></source>
<year>2008</year>
<volume>22</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>313</page-range></nlm-citation>
</ref>
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</back>
</article>
