<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-8178</journal-id>
<journal-title><![CDATA[Jornal Português de Gastrenterologia ]]></journal-title>
<abbrev-journal-title><![CDATA[J Port Gastrenterol.]]></abbrev-journal-title>
<issn>0872-8178</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Gastrenterologia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-81782009000600003</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Metastases supraclaviculares de adenocarcinoma do cólon]]></article-title>
<article-title xml:lang="en"><![CDATA[Supraclavicular metastasis of colon cancer]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pais]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Brehcist]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Crespo]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jesus]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fontes]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Furtado]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gervásio]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
<xref ref-type="aff" rid="A02"/>
</contrib>
</contrib-group>
<aff id="A02">
<institution><![CDATA[,Hospitais da Universidade de Coimbra Serviço de  Cirurgia II ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="A01">
<institution><![CDATA[,Instituto Português de Oncologia de Coimbra-Francisco Gentil, EPE Serviço de Oncologia Médica ]]></institution>
<addr-line><![CDATA[Coimbra ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2009</year>
</pub-date>
<volume>16</volume>
<numero>6</numero>
<fpage>240</fpage>
<lpage>243</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-81782009000600003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-81782009000600003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-81782009000600003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[INTRODUÇÃO: O adenocarcinoma é a variante histológica mais frequente do cancro do cólon e o fígado o local mais comum de metastização. A metastização ganglionar supraclavicular é pouco frequente, sendo raros os casos em que esta é a manifestação clínica inicial. Os autores apresentam o caso duma doente do sexo feminino, 41 anos de idade, com um conglomerado adenopático supraclavicular esquerdo com biópsia compatível com metástases de adenocarcinoma produtor de muco. Efectuou colonoscopia com biópsia que mostrou adenocarcinoma colo-rectal invasivo estenosante aparentemente do cólon transverso. Foi submetida a laparotomia exploradora que confirmou um carcinoma do ângulo hepático do cólon irressecável, metastização hepática e carcinomatose peritoneal. Discute-se o diagnóstico e a evolução clínica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[BACKGROUND: The most common histologic variant of colon cancer is adenocarcinoma and liver is the most frequent metastatic site. Supraclavicular lymph node metastases are rare. A few case reports describe supraclavicular lymph node metastases as the first clinical manifestation of colon cancer. The authors present the case report of a 41-year-old female patient with a conglomerate of lymph nodes in the left supraclavicular region. Biopsy confirmed metastases of a mucin-producing adenocarcinoma. Colonoscopy with biopsy revealed an obstructive invasive colorectal carcinoma probably of the transverse colon. The patient underwent explorative laparotomy which showed a carcinoma of the hepatic flexure that could not be removed with liver metastases and peritoneal carcinomatoses. Diagnostic approach and clinical evolution are discussed.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Cancro do cólon]]></kwd>
<kwd lng="pt"><![CDATA[metástases supraclaviculares]]></kwd>
<kwd lng="en"><![CDATA[Colon cancer]]></kwd>
<kwd lng="en"><![CDATA[supraclavicular lymph node metastases]]></kwd>
</kwd-group>
</article-meta>
</front><body><![CDATA[ <p><b>Metastases supraclaviculares de adenocarcinoma do cólon</b></p>      <p><b>Supraclavicular metastasis of colon cancer </b></p>      <p><b>&nbsp;</b></p>      <p>A. Pais<sup><a href="#1">1</a></sup><a name="top1"></a>, E. Brehcist<sup><a href="#1">1</a></sup>, F. Crespo<sup><a href="#1">1</a></sup>, E. Jesus<sup><a href="#2">2</a></sup><a name="top2"></a>, F. Fontes<sup><a href="#2">2</a></sup>, E. Furtado<sup><a href="#3">3</a></sup><a name="top3"></a>, H. Gervásio<sup><a href="#4">4</a></sup><a name="top4"></a></p>      <p>&nbsp;</p>      <p><b>Resumo</b></p>      <p>INTRODUÇÃO: O adenocarcinoma é a variante histológica mais frequente do cancro    do cólon e o fígado o local mais comum de metastização. A metastização ganglionar    supraclavicular é pouco frequente, sendo raros os casos em que esta é a manifestação    clínica inicial. Os autores apresentam o caso duma doente do sexo feminino,    41 anos de idade, com um conglomerado adenopático supraclavicular esquerdo com    biópsia compatível com metástases de adenocarcinoma produtor de muco. Efectuou    colonoscopia com biópsia que mostrou adenocarcinoma colo-rectal invasivo estenosante    aparentemente do cólon transverso. Foi submetida a laparotomia exploradora que    confirmou um carcinoma do ângulo hepático do cólon irressecável, metastização    hepática e carcinomatose peritoneal. Discute-se o diagnóstico e a evolução clínica.</p>      <p><b>Palavras-chave: </b>Cancro do cólon, metástases supraclaviculares.</p>      <p>&nbsp;</p>      <p><b>Abstract</b></p>      ]]></body>
<body><![CDATA[<p>BACKGROUND: The most common histologic variant of colon cancer is adenocarcinoma    and liver is the most frequent metastatic site. Supraclavicular lymph node metastases    are rare. A few case reports describe supraclavicular lymph node metastases    as the first clinical manifestation of colon cancer. The authors present the    case report of a 41-year-old female patient with a conglomerate of lymph nodes    in the left supraclavicular region. Biopsy confirmed metastases of a mucin-producing    adenocarcinoma. Colonoscopy with biopsy revealed an obstructive invasive colorectal    carcinoma probably of the transverse colon. The patient underwent explorative    laparotomy which showed a carcinoma of the hepatic flexure that could not be    removed with liver metastases and peritoneal carcinomatoses. Diagnostic approach    and clinical evolution are discussed.</p>      <p><b>Keywords</b>: Colon cancer, supraclavicular lymph node metastases.</p>      <p>&nbsp;</p>     <p>&nbsp;</p>      <p>Texto Completo disponível apenas em PDF     <p>Full text only available in PDF format</p>      <p>&nbsp;</p>     <p>&nbsp;</p>     <p><b>Bibliografia</b></p>      <p>1. J. Ferlay, P. Autier, M. Boniol, M. Heanue, M. Colombet and P. Boyle. Estimates    of the cancer incidence and mor­tality in Europe in 2006. Ann Oncol 2007;18(3):581-92.</p>      ]]></body>
<body><![CDATA[<p>2. N. Patel, P.R. Shah, E. Wilson and P.N. Haray. An unexpected supraclavicular swelling. J Surg Onc 2007;5:90-4.</p>      <!-- ref --><p>3. M. Carilho, L. Patrício. A Situação Demográfica Recente em Portugal. Revista de Estudos Demográficos 2005;38(6):111-41. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000024&pid=S0872-8178200900060000300001&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><p>4. J. Weitz, P. Kienle, A. Magener, M. Koch, A. Schrödel, F. Willeke et al. Detection of Disseminated Colorectal Cancer Cells in Lymph Nodes, Blood and Bone Marrow. Clin Cancer Res 1999;5:1830-6.</p>      <p>5. C. Cohade, M. Osman, H.K. Pannu and R.L. Wahl. Uptake in Supraclavicular Area Fat („USA-Fat“): Descrip­tion on 18F-FDG PET/CT. J Nucl Med 2003;44(2): 170-6.</p>      <p>6. K. Al-Saleh, A. Ali, A.M. Jaffer, T. Farghaley, M.A. Abdulla. Lymph Node Metastases in the Neck from Unk­nown Primary Sites. Med Princ Pract 2000;9:59-66.</p>      <p>7. H. Hurwitz. New Combinations in Metastatic Colorectal Cancer: What Are Our Expectations. Oncologist 2005;10(5): 20-322.</p>      <p>8. S. Politano, M. Overman, P. Pathak, R. Chadha, K. Glover, D.Z. Chang et al. Second-line chemotherapy use in metastatic colon cancer varies by disease responsive­ness. Clin Colorectal  Canc 2008;7(1):55-9. </p>      <p>9. K. Omura. Advances in Chemotherapy against Advanced or Metastatic Colorectal Cancer. Digestion 2008;77:13-22.</p>      <p>10. C. Tournigand, T. André, E. Achille, G. Lledo, M. Flesh, D. Mery-Mignard et al. FOLFIRI Followed by FOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer: A Randomized GERCOR Study. J Clin Oncol 2004;22(2): 229-37.</p>      <p>11. H. Hurwitz, L. Fehrenbacher, W. Novotny, T. Cartwright, J. Hainsworth, W. Heim et al. Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer. N Engl J Med 2004;350:2335-42.</p>      ]]></body>
<body><![CDATA[<p>12. D. Cunningham, Y. Humblet, S. Siena, D. Khayat, H. Bleiberg, A. Santoro et al. Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Me­tastatic Colorectal .N Engl J Med 2004;351:337-45.</p>      <p>13. T. Delaunoit1, S.R. Alberts, D.J. Sargent, E. Green, R.M. Goldberg, J. Krook et al. Chemotherapy Permits Resec­tion of Metastatic Colorectal Cancer: Experience from Intergroup N9741. Ann Oncol 2005;16(3):425-9.</p>      <p>14. A. Umar, C. Boland, J. Terdiman, S. Syngal, A. Chapelle, J. Rüschoff et al. Revised Bethesda Guidelines for Here­ditary Nonpolyposis Colorectal Cancer (Lynch Syndro­me) and Microsatellite Instability. J Nat Caner Ins 2004; 96(4):261-8.</p>      <p>&nbsp;</p>      <p>Serviço de Oncologia Médica, Instituto Português de Oncologia de Coimbra-Francisco    Gentil, EPE (IPOC-FG, EPE), Serviço de Cirurgia II, Hospitais da Universidade    de Coimbra; </p>     <p><sup><a name="1"></a><a href="#top1">1</a></sup> Interno do Internato Complementar    de Oncologia Médica, </p>     <p><sup><a name="2"></a><a href="#top2">2</a></sup>Assistente Hospitalar Graduado    de Oncologia Médica, </p>     <p><sup><a name="3"></a><a href="#top3">3</a></sup> Assistente Graduado de Cirurgia,  </p>     <p><sup><a name="4"></a><a href="#top4">4</a></sup> Directora do Serviço de Oncologia    Médica</p>     <p>&nbsp;</p>     ]]></body>
<body><![CDATA[<p><b>Correspondência</b>:</p>     <p>Ana Filipa Horta de Oliveira Cardoso Pais</p>     <p>Serviço de Oncologia Médica</p>     <p>Instituto Português de Oncologia de Coimbra-Francisco Gentil, EPE</p>     <p>Avenida Bissaya Barreto, 98; 3001-651 Coimbra, Portugal</p>     <p>Telefone: 239400200</p>     <p>E-mail: <a href="mailto:anapais.pais@gmail.com">anapais.pais@gmail.com</a></p>     <p>&nbsp;</p>      <p align="right" ><i>Recebido: 22/03/2008 e Aceite para Publicação: 30/07/2008</i></p>      ]]></body><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carilho]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Patrício]]></surname>
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<article-title xml:lang="pt"><![CDATA[A Situação Demográfica Recente em Portugal]]></article-title>
<source><![CDATA[Revista de Estudos Demográficos]]></source>
<year>2005</year>
<volume>38</volume>
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</back>
</article>
