Pulmonary function testing in bone marrow transplantation: A systematic review
Eliane Viana Mancuso1
Nilton Alves de Rezende2
Resumo
As complicações pulmonares constituem causa importante de morbidade e mortalidade em doentes submetidos a transplante de medula óssea. Os testes de função pulmonar são utilizados rotineiramente na avaliação antes e no acompanhamento após o transplante. A revisão sistemática da literatura mostrou que a presença de alterações nos testes de função pulmonar antes do transplante de medula não esteve relacionada com maior incidência de complicações pulmonares pós-transplante. Entretanto, alterações destes testes após o transplante estiveram relacionadas com maior incidência de complicações respiratórias. Desta forma, embora as alterações dos testes de função pulmonar pré-transplante não tenham sido de valor preditivo positivo na detecção precoce de complicações respiratórias pós-transplante, os mesmos podem ser úteis na comparação com os testes realizados após o transplante e devem fazer parte da avaliação de doentes candidatos ao transplante de medula óssea.
]]> Palavras-chave: Transplante de medula óssea, testes de função pulmonar, revisão sistemática.
Abstract
The pulmonary function test plays an important role in the management of pulmonary complications after bone marrow transplantation. Although its utility in helping to predict the likelihood of developing post transplant pulmonary complications and mortality is not well established, current data indicate that pre-transplant pulmonary function tests are important as a reference for the interpretation of post transplant pulmonary function tests and for identifying patients at high risk of developing pulmonary complications and/or mortality after bone marrow transplantation.
Key-words: Bone marrow transplantation, respiratory function tests, systematic review.
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Bibliografia
1. Madras TK, Salami JP, Chan CK, Lipton JH, Messer HA, Alpacas A. Pulmonary function abnormalities after allogeneic marrow transplantation: a systematic review and assessment of an existing predictive instrument. Bone Marrow Transplant 2002; 30: 599-607. [ Links ]
2. Chine JW, Mates DK, Clark, JG. Pulmonary function testing prior to hematopoietic stem cell transplantation. Bone Marrow Transplant 2005; 35: 429-435. [ Links ]
3. Marras TK, Chan CK, Lipton JH, Messner HA, Szalai JP, Laupacis A. Long-term pulmonary function abnormalities and survival after allogenic marrow transplantation. Bone Marrow Transplant 2004; 33: 509-517. [ Links ]
4. Badier M, Guillot C, Delpierre S, Vanuxem P, Blaise D, Maraninchi D. Pulmonary function changes 100 days and one year after bone marrow transplantation. Bone Marrow Transplant 1993; 12:457-461. [ Links ]
5. Jain B, Floreani AA, Anderson JR, Vose JM, Robbins RA, Rennard SI, Sisson JH. Cardiopulmonary function and autologous bone marrow transplantation: results and predictive value for respiratory failure and mortality. The University of Nebraska Medical Center Bone Marrow Transplantation Pulmonary Study Group. Bone Marrow Transplant 1996; 17:561-568. [ Links ]
6. Cerveri I, Zoia MC, Fulgoni P, Corsico A, Casali L, Tinelli C, Zecca M, Giorgiani G, Locatelli F. Late pulmonary sequelae after childhood bone marrow transplantation. Thorax 1999; 54:131-135. [ Links ]
7. Ratanatharathorn V, Ayash L, Lazarus HM, Fu J, Uberti JP. Chronic grafty-versus-host disease: clinical manifestation and therapy. Bone Marrow Transplant 2001; 28:121-129. [ Links ]
8. Nenadov Beck M, Meresse V, Hartmann O, Gaultier C. Long-term pulmonary sequelae after autologous bone marrow transplantation in children without total body irradiation. Bone Marrow Transplant 1995; 16:771-775. [ Links ]
9. Depledge MH, Barrett A, Powles RL. Lung function after bone marrow grafting. Int J Radiat Oncol Biol Phys 1983; 9:145-151. [ Links ]
10. Link H, Reinhard U, Blaurock M, Ostendorf P. Lung function changes after allogenic bone marrow transplantation. Thorax 1986; 41:508-512. [ Links ]
11. Clark JG, Schwartz DA Flournoy N et al. Risk factors for airflow obstruction in recipients of bone marrow transplants. Ann Intern Med 1987; 107:648-656. [ Links ]
12. Sutedja TG, Apperley JF, Hughes JMB et al. Pulmonary function after bone marrow transplantation for chronic myeloid leukemia. Thorax 1988; 43:163-169. [ Links ]
13. Prince DS, Wingard JR, Saral R et al. Longitudinal changes in pulmonary function following bone marrow transplantation. Chest 1989; 96:301-306. [ Links ]
14. Tait RC, Burnett AK, Robertson AG et al. Subclinical pulmonary function defects following autologous and allogenic bone marrow transplantation: relationship to total body irradiation and graft-versus-host disease. Int J Radiat Oncol Biol Phys 1991; 20:1219-1227 [ Links ]
15. Crawford SW, Fisher L. Predictive value of pulmonary function tests before marrow transplantation. Chest 1992; 101:1257-1264. [ Links ]
16. Ghalie R, Szidon JP, Thompson L, Nawas YN, Dolce A, Kaizer H. Evaluation of pulmonary complications after bone marrow transplantation: the role of pretransplant pulmonary function tests. Bone Marrow Transplant 1992; 10:359-365. [ Links ]
17. Schwarer AP, Hughes JM, Trotman-Dickenson B, Krausz T, Goldman JM. A chronic pulmonary syndrome associated with graft-versus-host disease after allogeneic marrow transplantation. Transplant 1992; 54:1002-1008. [ Links ]
18. Kaplan EB, Wodell RA, Wilmott RW et al. Late effects of bone marrow transplantation on pulmonary function in children. Bone Marrow Transplant 1994; 14:613-621. [ Links ]
19. Schultz KR, Green GJ, Wensley D et al. Obstructive lung disease in children after allogeneic bone marrow transplantation. Blood 1994; 84:3212-3220. [ Links ]
20. Quigley PM, Yeager AM, Loughlin GM. The effects of bone marrow transplantation on pulmonary function in children. Pediatr Pulmonol. 1994; 18:361-367. [ Links ]
21. Carlson K, Backlund L, Smedmyr B, Oberg G, Simonsson B. Pulmonary function and complications subsequent to autologous bone marrow transplantation. Bone Marrow Transplant 1994; 14:805-811. [ Links ]
22. Arvidson J, Bratteby LE, Carlson K, Hagberg H, Kreuger A, Simonsson B, Smedmyr B, Taube A, Oberg G, Lonnerholm G. Pulmonary function after autologous bone marrow transplantation in children. Bone Marrow Transplant 1994; 14:117-123. [ Links ]
23. Crawford SW, Pepe M, Lin D, Benedetti F, Deeg HJ. Abnormalities of pulmonary function tests after marrow transplantation predict nonrelapse morta-lity. Am J Respir Crit Care Med 1995; 152:690-695. [ Links ]
24. Curtis DJ, Smale A, Thien F et al. Chronic airflow obstruction in long-term survivors of allogeneic bone marrow transplantation. Bone Marrow Transplant 1995; 16:169-173. [ Links ]
25. Lund MB, Kongerud J, Brinch L et al. Decreased lung function in one year survivors of allogeneic bone marrow transplantation conditioned with high-dose busulphan and cyclophosphamide. Eur Respir J 1995; 8:1269-1274. [ Links ]
26. Beinert T, Dull T, Wolf K, Holler E, Vogelmeier C, Behr J, Kolb H. Late pulmonary impairment following allogeneic bone marrow transplantation. Eur J Med Res 1996; 18:343-348. [ Links ]
27. Gore EM, Lawton CA, Ash RC, Lipchik RJ. Pulmonary function changes in long-term survivors of bone marrow transplantation. Int J Radiat Oncol Biol Phys 1996; 36:67-75. [ Links ]
28. Nyson K, Holm K, Hesse B et al. Lung function after allogeneic bone marrow transplantation for leukemia or lymphoma. Arch Dis Child 1996; 74:432-436. [ Links ]
29. Fanfulla F, Locatelli F, Zoia MC, Giorgiani G, Bonetti F, Spagnolatti L, Cerveri Pulmonary complications and respiratory function changes after bone marrow transplantation in children. Eur Respir J 1997; 10:2301-2306. [ Links ]
30. Kreuzfelder E, Scheiber G, Quabeck K, Schaefer UW, Bruch J, Costabel U, Grosse-Wilde H. Alveolo-capillary protein permeability and lung function in patients with late pulmonary complications after allogeneic bone marrow transplantation. Lung 1998; 176:99-109. [ Links ]
31. Matute-Bello G, McDonald GD, Hinds MS, Schoch HG, Crawford SW. Association of pulmonary function testing abnormalities and severe veno-occlusive disease of the liver after marrow transplantation. Bone Marrow Transplant 1998; 21:1125-1130. [ Links ]
32. Leneveu H, Bremont F, Rubie H, Peyroulet MC, Broue A, Suc A, Robert A, Dutau G. Respiratory function in children undergoing bone marrow transplantation. Pediatr Pulmonol 1999; 28:31-38. [ Links ]
33. Cerveri I, Fulgoni P, Giorgiani G, Zoia MC, Beccaria M, Tinelli C, Locatelli F. Lung function abnormalities after bone marrow transplantation in children. Chest 2001; 120:1900-1906. [ Links ]
34. Chien JW, Martin PJ, Gooley TA et al. Airflow obstruction after myeloablative allogeneic hematopoietic stem cell transplantation. Am J Respir Crit Care Med 2003; 168:208-214. [ Links ]
35. Frisk P, Arvidson J, Bratteby LE, Hedenstrom H, Lonnerholm G. Pulmonary function after autologous bone marrow transplantation in children: a long-term prospective study. Bone Marrow Transplant 2004; 33:645-650. [ Links ]
36. Chien JW, Martin PJ, Flowers ME, Nichols WG, Clark JG. Implications of early airflow decline after myeloablative allogeneic stem cell transplantation. Bone Marrow Transplant 2004; 33:759-764. [ Links ]
37. Ralph DD, Springmeyer SC, Sullivan KM, Hackman RC, Storb R, Thomas ED. Rapidly progressive air-flow obstruction in marrow transplant recipients. Possible association between obliterative bronchiolitis and chronic graft-versus-host disease. Am Rev Respir Dis 1984; 129:641-644. [ Links ]
38. Thirman MJ, Devine SM, O'Toole K, Cizek G, Jessurun J, Hertz M, Geller RB. Bronchiolitis obliterans organizing pneumonia as a complication of allogeneic bone marrow transplantation. Bone Marrow Transplant 1992; 10:307-311. [ Links ]
39. Gerhardt, SG, Macdayer JF, Girgis RE, Conte JV, Yang SC, Oreans, JB. Maintenance azithromycin therapy for bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 2003; 168:121-125. [ Links ]
40. Kotloff RM, Ahya VN, Crawford SW. Pulmonary complications of Solid Organ and Hematopoietic Stem Cell Transplantation. Am J Resp Crit Care Med 2004; 170:22-48. [ Links ]
41. Tomas LHS, Loberiza FR, Klein JP, Layde PM, Lipchik RJ, Rizzo JD, Bredeson CN, Horowitz MM. Risk factors for bronquiolitis obliterans in allogeneic hematopoietic stem-cell transplantation for leukemia. Chest 2005; 128:153-161. [ Links ]
1 Mestranda do Programa de Pós-Graduação em Clínica Médica da Universidade Federal de Minas Gerais, Brasil.
2 Professor Adjunto do Departamento de Clínica Médica da Faculdade de Medicina da Universidade Federal de Minas Gerais, Brasil. Doutor em Medicina.
Pós-Doutorado, Emory University, Atlanta, USA.
Trabalho realizado no Serviço de Pneumologia e Transplante de Medula Óssea do Hospital das Clínicas da Universidade Federal de Minas Gerais, Brasil.
Endereço para correspondência: Professor Nilton Alves de Rezende. Departamento de Clínica Médica, Faculdade de Medicina da UFMG ]]>
Al. Alfredo Balena 190CEP-30130-100
Belo Horizonte, Brasil.
e-mail: narezende@terra.com.br
Recebido para publicação/received for publication: 05.10.07
Aceite para publicação/accepted for publication: 06.01.09
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