<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0873-2159</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Pneumologia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Pneumol]]></abbrev-journal-title>
<issn>0873-2159</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Pneumologia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0873-21592006000600005</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Asma, polipose nasal e intolerância à aspirina: Uma tríade a recordar]]></article-title>
<article-title xml:lang="en"><![CDATA[Asthma, nasal polyposis and aspirin intolerance: A triad to remember]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Seabra]]></surname>
<given-names><![CDATA[Bárbara]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duarte]]></surname>
<given-names><![CDATA[Raquel]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sá]]></surname>
<given-names><![CDATA[Raul César]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Centro Hospitalar Vila Nova de Gaia Serviço de Pneumologia ]]></institution>
<addr-line><![CDATA[V. N. Gaia ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>11</month>
<year>2006</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>11</month>
<year>2006</year>
</pub-date>
<volume>12</volume>
<numero>6</numero>
<fpage>709</fpage>
<lpage>714</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0873-21592006000600005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0873-21592006000600005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0873-21592006000600005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Apesar de reconhecida há mais de meio século, a tríade constituída por asma severa, polipose nasal e intolerância ao ácido acetilsalicílico a denominada asma induzida pela aspirina ou sindrome de Widal permanece francamente subdiagnosticada e insuficientemente tratada. De entre as principais razões para esta situação destacam-se o desconhecimento das suas características clínicas, a fisiopatologia e, por vezes, até a própria existência desta entidade. O presente artigo pretende alertar a população médica para esta síndroma, para as suas particularidades e para os cuidados específicos no seu tratamento, com vista a uma melhoria na prestação dos cuidados de saúde: O diagnóstico correcto é o primeiro passo no tratamento eficaz de qualquer patologia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Despite more than a half-century of recognition, the triad characterised by severe asthma, nasal polyposis and acetylsalicylic acid intolerance known as aspirin induced asthma or Widal’s triad remains markedly underdiagnosed and mistreated. A number of reasons may contribute to this situation with the lack of awareness of its clinical characteristics, pathophysiology and even sometimes of its’ actual existence the main ones. This review article aims to alert physicians to this entity and its particularities in an attempt to improve healthcare. A correct diagnosis is the first step in the effective treatment of a disease.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Asma]]></kwd>
<kwd lng="pt"><![CDATA[polipose nasal]]></kwd>
<kwd lng="pt"><![CDATA[intolerância aspirina]]></kwd>
<kwd lng="pt"><![CDATA[síndroma de Widal]]></kwd>
<kwd lng="en"><![CDATA[Asthma]]></kwd>
<kwd lng="en"><![CDATA[nasal polyposis]]></kwd>
<kwd lng="en"><![CDATA[aspirin intolerance]]></kwd>
<kwd lng="en"><![CDATA[Widal syndrome]]></kwd>
</kwd-group>
</article-meta>
</front><body><![CDATA[ <p><b>Asma, polipose nasal e intolerância à aspirina &#8211; Uma tríade a recordar</b></p>      <p><b>Asthma, nasal polyposis and aspirin intolerance &#8211; A triad to remember</b></p>      <p>&nbsp;</p>      <p><b>Bárbara Seabra <sup><a href="#1">1</a><a name="top1"></a></sup></b></p>      <p><b>Raquel Duarte <sup><a href="#2">2</a><a name="top2"></a></sup></b></p>      <p><b>Raul César Sá <sup><a href="#3">3</a><a name="top3"></a></sup></b></p>      <p>&nbsp;</p>      <p align="center"><b>Resumo</b></p>      <p align="justify">Apesar de reconhecida há mais de meio século, a tríade constituída    por asma severa, polipose nasal e intolerância ao ácido acetilsalicílico a denominada    <b>asma induzida pela aspirina </b>ou <b>sindrome</b><b> de Widal </b>permanece    francamente subdiagnosticada e insuficientemente tratada. De entre as principais    razões para esta situação destacam-se o desconhecimento das suas características    clínicas, a fisiopatologia e, por vezes, até a própria existência desta entidade.    O presente artigo pretende alertar a população médica para esta síndroma, para    as suas particularidades e para os cuidados específicos no seu tratamento, com    vista a uma melhoria na prestação dos cuidados de saúde: O diagnóstico correcto    é o primeiro passo no tratamento eficaz de qualquer patologia.</p>     <p align="justify"><b>Palavras-chave: </b>Asma, polipose nasal, intolerância aspirina,    síndroma de Widal.</p>      ]]></body>
<body><![CDATA[<p>&nbsp;</p>      <p align="center"><b>Abstract</b></p>      <p align="justify">Despite more than a half-century of recognition, the triad    characterised by severe asthma, nasal polyposis and acetylsalicylic acid intolerance    known as <b>aspirin induced asthma </b>or <b>Widal&#8217;s</b><b> triad </b>remains    markedly underdiagnosed and mistreated. A number of reasons may contribute to    this situation with the lack of awareness of its clinical characteristics, pathophysiology    and even sometimes of its&#8217; actual existence the main ones. This review article    aims to alert physicians to this entity and its particularities in an attempt    to improve healthcare. A correct diagnosis is the first step in the effective    treatment of a disease.</p>     <p align="justify"><b>Keywords</b>: Asthma, nasal polyposis, aspirin intolerance,    Widal syndrome.</p>      <p>&nbsp;</p>      <p>Texto completo disponível apenas em PDF.</p>     <p>Full text only available in PDF format.</p>      <p>&nbsp;</p>      <p align="center"><b>Bibliografia</b><b></b></p>      <!-- ref --><p>1. M F Widal, P Abrami, J Lermoyez. Anaphylaxie et idiosyncrasie. La Presse Médicale, Paris, 1922, 30: 189-192.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000022&pid=S0873-2159200600060000500001&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><p>2. Bochenek G, Banska K, Szabo Z, Nizankowska E, Szczeklik A. Diagnosis, Prevention  and Treatment of Aspirin-Induced Asthma and Rhinitis. Current Drug Targets&#8211; Inflammation &amp;Allergy 2002; (1):1-11.</p>      <p>3. Settipane R A, Stevenson D D. Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma. J Allergy Clinical Immunology 1989; 84 (1): 26-33.</p>      <p>4. Babu K S, Salvi S S. Aspirin and Asthma. Chest 2000; 118:1470-1476.</p>      <p>5. Dahlen B, Nizankowska E, Szczeliik A, Bochenek G, Kumlin M. Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin intolerant asthmatics. Am J Respiratory Care Med 1998; 157: 11887-96</p>      <p>6. Israel E, Fisher E R, Rosenberg M A. The pivotal role of lipoxigenase products in the reaction of aspirin sensitive asthmatics to aspirin. Am Rev Respiratory Dis 1993; 148:1447</p>      <p>7. Sweet JM, Stevenson DD, Mathison DA. Long term effects of asthma desensitization &#8211; treatment of aspirin induced rhinosinusitis-asthma. J Clin Immunol 1990; 85:59.</p>      <p>&nbsp;</p>      <p><sup><a href="#top1">1</a><a name="1"></a></sup> Interna Complementar de Pneumologia</p>      <p><sup><a href="#top2">2</a><a name="2"></a></sup> Assistente Hospitalar de Pneumologia</p>      <p><sup><a href="#top3">3</a><a name="3"></a></sup> Director do Serviço de Pneumologia</p>      ]]></body>
<body><![CDATA[<p>&nbsp;</p>      <p>Centro Hospitalar Vila Nova de Gaia</p>     <p>Serviço de Pneumologia</p>     <p>Rua Conceição Fernandes</p>     <p>4434-502 V. N. Gaia</p>      <p>&nbsp;</p>      <p>Recebido para publicação/received for publication: 06.03.03</p>     <p>Aceite para publicação/accepted for publication: 06.06.30</p>       ]]></body><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Widal]]></surname>
<given-names><![CDATA[M F]]></given-names>
</name>
<name>
<surname><![CDATA[Abrami]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Lermoyez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Anaphylaxie et idiosyncrasie.: La Presse Médicale]]></source>
<year>1922</year>
<volume>30</volume>
<page-range>189-192</page-range><publisher-loc><![CDATA[Paris ]]></publisher-loc>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
