<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1646-2890</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Estomatol Med Dent Cir Maxilofac]]></abbrev-journal-title>
<issn>1646-2890</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Estomatologia e Medicina Dentária]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1646-28902025000100031</article-id>
<article-id pub-id-type="doi">10.24873/j.rpemd.2025.03.1419</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Report of two rare cases of plasma cell granuloma of the gengiva]]></article-title>
<article-title xml:lang="pt"><![CDATA[Relato de dois casos raros de granuloma de células plasmocitárias da gengiva]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morais]]></surname>
<given-names><![CDATA[Hannah Gil de Farias]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[Renata Roque]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguiar Júnior]]></surname>
<given-names><![CDATA[José Nazareno Moreira de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santo]]></surname>
<given-names><![CDATA[Victor Diniz Borborema dos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lucena]]></surname>
<given-names><![CDATA[Hevio Freitas de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Freitas]]></surname>
<given-names><![CDATA[Roseana de Almeida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Federal University of Rio Grande do Norte Department of Dentistry Postgraduate Program in Dental Sciences]]></institution>
<addr-line><![CDATA[Natal RN]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Federal University of Rio Grande do Norte  ]]></institution>
<addr-line><![CDATA[Natal RN]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Private practice  ]]></institution>
<addr-line><![CDATA[Natal RN]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<volume>66</volume>
<numero>1</numero>
<fpage>31</fpage>
<lpage>37</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S1646-28902025000100031&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S1646-28902025000100031&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S1646-28902025000100031&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Plasma cell granuloma is a rare benign, occasionally aggressive lesion with an unclear etiopathogenesis characterized by plasma cell infiltration. It occurs mainly in the lungs but can also affect the liver, kidneys, brain, and heart. Its occurrence in the oral cavity is rare. In this study, we report two rare cases of plasma cell granuloma involving the maxillary gengiva in a middle-aged male patient and a pregnant woman. In both cases, the lesion appeared red and bleeding. Following excisional biopsy, the specimens were subjected to histopathological analysis and immunohistochemical confirmation, leading to a diagnosis of plasma cell granuloma. Both patients are under monitoring and show no signs of recurrence. The authors also discuss plasma cell granuloma&#8217;s clinical, histopathological, and immunohistochemical features. Histopathological examination and complementary immunohistochemistry are crucial for its correct diagnosis. Despite its benign behavior, plasma cell granuloma&#8217;s local aggressiveness, rarity in the oral cavity, and similarity with other benign and malignant lesions of the gingiva make its diagnosis difficult.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo O granuloma de células plasmocitárias é uma lesão benigna rara, ocasionalmente agressiva, com etiopatogenia obscura, caracterizada pela infiltração de células plasmáticas. Ocorre principalmente nos pulmões, mas também pode afetar o fígado, os rins, o cérebro e o coração. A sua ocorrência na cavidade oral é rara. Neste estudo, relatamos dois casos raros de granuloma de células plasmocitárias envolvendo a gengiva maxilar num paciente do sexo masculino de meia-idade e numa mulher grávida. Em ambos os casos, a lesão apresentava-se avermelhada e sangrante. Após a biópsia excisional, os espécimes foram submetidos a análise histopatológica e confirmação imuno-histoquímica, levando ao diagnóstico de granuloma de células plasmáticas. Ambos os pacientes estão sob acompanhamento e não demonstraram sinais de recidiva. Os autores também discutem as características clínicas, histopatológicas e imuno-histoquímicas. O exame histopatológico e a imunohistoquímica complementar são cruciais para o correto diagnóstico do granuloma de células plasmocitárias. Apesar do seu comportamento benigno, a agressividade local do granuloma de células plasmocitárias, a sua raridade na cavidade oral e o facto de poder mimetizar outras lesões benignas e malignas da gengiva dificultam o diagnóstico desta lesão.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Case reports]]></kwd>
<kwd lng="en"><![CDATA[Gingiva]]></kwd>
<kwd lng="en"><![CDATA[Plasma cell granuloma]]></kwd>
<kwd lng="en"><![CDATA[Plasma cells]]></kwd>
<kwd lng="pt"><![CDATA[Relatos de caso]]></kwd>
<kwd lng="pt"><![CDATA[Gengiva]]></kwd>
<kwd lng="pt"><![CDATA[Granuloma de células plasmáticas]]></kwd>
<kwd lng="pt"><![CDATA[Células plasmáticas]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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