<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1646-5830</journal-id>
<journal-title><![CDATA[Acta Obstétrica e Ginecológica Portuguesa]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Obstet Ginecol Port]]></abbrev-journal-title>
<issn>1646-5830</issn>
<publisher>
<publisher-name><![CDATA[Euromédice, Edições Médicas Lda.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1646-58302021000200117</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Translucência da nuca aumentada em fetos euploides e neurodesenvolvimento a longo prazo]]></article-title>
<article-title xml:lang="en"><![CDATA[Increased nuchal translucency in euploid fetuses and long-term neurodevelopment]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Vanessa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Almeida]]></surname>
<given-names><![CDATA[Gabi]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[Sílvia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Miguelote]]></surname>
<given-names><![CDATA[Rui]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Senhora da Oliveira Serviço de Ginecologia e Obstetrícia ]]></institution>
<addr-line><![CDATA[Guimarães ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Braga Serviço de Medicina Física e de Reabilitação ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade do Minho Escola de Medicina Instituto de Ciências da Vida e da Saúde]]></institution>
<addr-line><![CDATA[Braga ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Senhora da Oliveira Serviço de Ginecologia e Obstetrícia ]]></institution>
<addr-line><![CDATA[Guimarães ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>15</volume>
<numero>2</numero>
<fpage>117</fpage>
<lpage>124</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S1646-58302021000200117&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S1646-58302021000200117&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S1646-58302021000200117&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Overview and Aims:  To investigate the association between fetal nuchal translucency (NT) thickness and perinatal and long-term neurodevelopmental outcomes in singleton euploid pregnancies, in the absence of chromosomal and structural anomalies or confirmed genetic syndromes.  Study design, Population and Methods:  Retrospective cohort study including 1648 pregnant women submitted to routine first-trimester screening in a portugueses central hospital between December 2014 and December 2015. Three groups were defined by NT thickness: NT&lt;95th percentile, 212 cases - randomly selected in a 2:1 ratio to cases with increased NT; NT&gt; 95th-99th percentile, 89 cases (5,4%); and NT&gt;99th percentile, 16 cases (1,0%). Gestational and perinatal outcomes were compared in the three groups. Additionally, a screening tool for neurodevelopmental delay (Parent Report of Children&#8217;s Abilities - PARCA) was applied, with follow-up at a mean age of 2,0 years.  Results:  For children with a NT&gt;99th percentile, there was a 7-fold increased risk of positive screening for neurodevelopmental delay (OR 6,80, 95% CI 0,03-0,65; 3 cases). For children with NT between the 95th and 99th percentile, the risk was also increased - about 3-fold (OR 2,9, 95% CI 0,12-0,94; 9 cases). Both results were compared with the group of children with NT&lt;95th percentile (7 cases). No significant statistical differences were found between the groups regarding perinatal outcomes, except for fetal sex. The prevalence of fetuses with NT 95th-99th percentile was higher in males (59 cases, 66,3%), compared to fetuses with NT&lt;95th percentile (106 cases, 56,7%).  Conclusions:  Among euploid fetuses with increased TN, there was an increased risk of positive screening for neurodevelopmental delay, particularly when NT&gt;99th percentile. This does not represent a turning point in counselling, but alerts to the need for long-term follow-up of these children and the potential benefits of clinically assessing their neurodevelopment.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Nuchal translucency measurement]]></kwd>
<kwd lng="en"><![CDATA[Pregnancy outcomes]]></kwd>
<kwd lng="en"><![CDATA[Child development disorders]]></kwd>
<kwd lng="en"><![CDATA[Follow-Up study]]></kwd>
</kwd-group>
</article-meta>
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