<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1646-5830</journal-id>
<journal-title><![CDATA[Acta Obstétrica e Ginecológica Portuguesa]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Obstet Ginecol Port]]></abbrev-journal-title>
<issn>1646-5830</issn>
<publisher>
<publisher-name><![CDATA[Euromédice, Edições Médicas Lda.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1646-58302023000100038</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Sentinel lymph node mapping in endometrial cancer using indocyanin green and infrared flourescence]]></article-title>
<article-title xml:lang="pt"><![CDATA[Pesquisa de gânglio sentinela com verde de indocianina e fluorescência infravermelha no cancro do endométrio]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sales]]></surname>
<given-names><![CDATA[Sara Sousa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Melo]]></surname>
<given-names><![CDATA[Ângela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gonçalves]]></surname>
<given-names><![CDATA[Sónia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[Nuno Nogueira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[Francisco Nogueira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Hospitalar Tondela-Viseu  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<volume>17</volume>
<numero>1</numero>
<fpage>38</fpage>
<lpage>44</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S1646-58302023000100038&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S1646-58302023000100038&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S1646-58302023000100038&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Overview and Aims:  Sentinel lymph node (SLN) biopsy in endometrial cancer has emerged as an alternative to systematic lymphadenectomy, with cervical indocyanin green injection being the preferred method.  Study Design, Population and Methods:  A prospective cohort study to assess the feasibility of SLN mapping in EC using ICG and near-infrared (NIR) fluorescence is ongoing at the authors&#8217; Gynaecological Oncology Unit, in a Portuguese level III care hospital. The authors conducted a descriptive analysis of the clinicopathologic characteristics and discuss the process of implementing a novel technique.  Results:  A minimum number of 20 patients with EC of all histologies and grades recruited until publication was established. Of all 20 patients, 12 (12/20; 60.0%) had a total laparoscopic hysterectomy plus bilateral salpingo-oophorectomy (TLH/BSO) and SLN biopsy alone, and the remaining 8 patients underwent full retroperitoneal staging (8/20; 40.0%). At least 1 SLN was detected in all patients (20/20; 100%), bilaterally in 14 (14/20; 70%) and unilaterally in 6 (6/20; 30%). In 1 case, a third SLN was identified amongst presacral nodes. No isolated para-aortic SLNs were detected. The median number of SLNs removed per patient was 2.3 (range 1-3). Out of the 20 patients, 2 (2/20; 10%) had lymph node metastases and in both cases bilateral detection of SLN did not occur. The median operative time was 240 minutes, with total SLN mapping time of approximately 40 minutes per side. Median operative time was lower among patients undergoing an SLN mapping only, compared with patients undergoing a full lymphadenectomy (219min vs 280min). No cases of ICG injection-related complications occurred. Ultrastaging of sentinel lymph nodes was performed in all cases.  Conclusions:  This is the first published series of laparoscopic sentinel lymph node biopsy using ICG and NIR fluorescence in endometrial cancer, conducted in a Portuguese hospital.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução e Objetivos:  A biópsia de gânglio sentinela (BGS) no carcinoma do endométrio surgiu como alternativa à linfadenectomia sistemática, privilegiando-se a injeção intracervical de verde de indocianina.  Métodos:  Foi realizado um estudo coorte prospetivo com o intuito de avaliar a reprodutibilidade da BGS com verde de indocianina no carcinoma do endométrio, num Hospital Português de nível III. Procedeu-se à análise descritiva das caraterísticas clinico-patológicas da população estudada e discussão do processo de implementação da nova técnica.  Resultados:  Estabeleceu-se um mínimo de 20 doentes com carcinoma do endométrio até publicação, incluindo todos os graus e tipos histológicos. Entre as 20 doentes recrutadas, 12 (12/20; 60%) foram submetidas a histerectomia total e anexectomia bilateral (HTL/AB) e BGS e as 8 restantes a estadiamento retroperitoneal completo (8/20; 40%). Foi detetado pelo menos 1 gânglio sentinela (GS) em todos os casos (20/20; 100%), bilateralmente em 14 (14/20; 70%) e unilateralmente em 6 (6/20; 30%). Um terceiro GS sagrado foi identificado num caso. Não se identificaram GS para-aórticos. O número médio de GS removidos em cada doente foi 2.3 (intervalo 1-3). Entre as 20 doentes, 2 (2/20; 10%) apresentaram metastização ganglionar e em ambos os casos não foi possível identificar bilateralmente o GS. O tempo operatório médio foi 240 minutos e o tempo dedicado ao mapeamento ganglionar 40 minutos, unilateralmente. O tempo operatório médio foi inferior nas doentes submetidas a BGS, comparativamente à linfadenectomia sistemática (219 minutos vs 280 minutos). Não houve complicações associadas à injeção do marcador. Foi realizado ultraestadiamento em todos os casos.  Conclusões:  A presente publicação é a primeira série de casos portuguesa reportada de biópsia de gânglio sentinela com verde de indocianina, por via laparoscópica no carcinoma do endométrio.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Indocyanin green]]></kwd>
<kwd lng="en"><![CDATA[Cervical injection]]></kwd>
<kwd lng="en"><![CDATA[Sentinel lymph node biopsy]]></kwd>
<kwd lng="en"><![CDATA[Lymph node mapping]]></kwd>
<kwd lng="en"><![CDATA[Endometrial cancer]]></kwd>
<kwd lng="pt"><![CDATA[Verde de indocianina]]></kwd>
<kwd lng="pt"><![CDATA[Injeção intracervical]]></kwd>
<kwd lng="pt"><![CDATA[Biópsia de gânglio sentinela]]></kwd>
<kwd lng="pt"><![CDATA[Estadiamento ganglionar]]></kwd>
<kwd lng="pt"><![CDATA[Carcinoma do endométrio]]></kwd>
</kwd-group>
</article-meta>
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