<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1646-5830</journal-id>
<journal-title><![CDATA[Acta Obstétrica e Ginecológica Portuguesa]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Obstet Ginecol Port]]></abbrev-journal-title>
<issn>1646-5830</issn>
<publisher>
<publisher-name><![CDATA[Euromédice, Edições Médicas Lda.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1646-58302024000100035</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Contraceção oral combinada e sua associação ao cancro da mama: uma revisão sistemática]]></article-title>
<article-title xml:lang="en"><![CDATA[Combined oral contraceptive and its association with breast cancer: a systematic review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Caetano]]></surname>
<given-names><![CDATA[Beatriz Leite]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Conde]]></surname>
<given-names><![CDATA[Maria Margarida Gil]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[Alda Pereira da Silva]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade de Lisboa Faculdade de Medicina ]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade de Lisboa Faculdade de Medicina Clínica Universitária de Medicina Geral e Familiar]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,ARSLVT Secção de Investigação Comissão de Ética para a Saúde]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade de Lisboa Faculdade de Medicina Clínica Universitária de Medicina Geral e Familiar]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>03</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>03</month>
<year>2024</year>
</pub-date>
<volume>18</volume>
<numero>1</numero>
<fpage>35</fpage>
<lpage>45</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S1646-58302024000100035&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S1646-58302024000100035&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S1646-58302024000100035&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo O cancro da mama é a doença maligna mais frequentemente diagnosticada nas mulheres em todo o mundo, com incidência e mortalidade crescentes, pelo que o conhecimento dos seus fatores de risco é de grande importância para se poder investir em medidas de prevenção primária eficazes. O contracetivo oral combinado (COC) é o método contracetivo mais utilizado em mulheres em idade fértil, com utilização média de 5 anos. Esta revisão sistemática pretende avaliar se existe maior incidência de cancro da mama em mulheres em idade fértil com exposição a COC superior a 5 anos, comparativamente a exposição inferior a 5 anos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Breast cancer is the most frequently diagnosed malignant disease in women worldwide, with increasing incidence and mortality, therefore the knowledge of its risk factors is of great importance to be able to invest in effective primary prevention measures. The combined oral contraceptive (COC) is the most widely used contraceptive method in women of childbearing age, with an average use of 5 years. This systematic review aims to assess whether there is a higher incidence of breast cancer in women of childbearing age with exposure to COC for more than 5 years, compared to less than 5 years of exposure.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Mulheres pré-menopausa]]></kwd>
<kwd lng="pt"><![CDATA[Contracetivo oral combinado]]></kwd>
<kwd lng="pt"><![CDATA[Cancro da mama]]></kwd>
<kwd lng="en"><![CDATA[Premenopausal women]]></kwd>
<kwd lng="en"><![CDATA[Combined oral contraceptive]]></kwd>
<kwd lng="en"><![CDATA[Breast cancer]]></kwd>
</kwd-group>
</article-meta>
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