<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1646-706X</journal-id>
<journal-title><![CDATA[Angiologia e Cirurgia Vascular]]></journal-title>
<abbrev-journal-title><![CDATA[Angiol Cir Vasc]]></abbrev-journal-title>
<issn>1646-706X</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Angiologia e Cirurgia Vascular]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1646-706X2021000300223</article-id>
<article-id pub-id-type="doi">10.48750/acv.416</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Predictors for development of peripheral arterial disease in pancreas-kidney transplant patients and impact on outcomes]]></article-title>
<article-title xml:lang="pt"><![CDATA[Preditores para o desenvolvimento de doença arterial periférica nos doentes submetidos a transplante reno pancreático e impacto nos resultados]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreira]]></surname>
<given-names><![CDATA[Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendes]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[La Salete]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Almeida]]></surname>
<given-names><![CDATA[Rui]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Ivone]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Hospitalar Universitário do Porto Serviço de Angiologia e Cirurgia Vascular ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro Hospitalar Universitário do Porto Serviço de Nefrologia ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>09</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>09</month>
<year>2021</year>
</pub-date>
<volume>17</volume>
<numero>3</numero>
<fpage>223</fpage>
<lpage>231</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S1646-706X2021000300223&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S1646-706X2021000300223&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S1646-706X2021000300223&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  The risk of peripheral arterial disease (PAD) is significantly increased in patients with type 1 diabetes mellitus who have developed chronic kidney disease. Pancreas kidney transplantation seems to be a promising option for these patients as it corrects both dysfunctions. The traditional risk factors for PAD are well defined in the general population. However, in patients undergoing simultaneous pancreas kidney transplant (SPKT) its influence is not well characterized.  Objective:  The aim of this study was to identify possible risk factors that influence the development and progression of PAD in pancreas-kidney transplanted patients and assess the outcomes of PAD on this population.  Methods:  We made a retrospective observational study of a group of 229 patients with type I diabetes mellitus and end stage renal disease who underwent pancreas-kidney transplantation. Demographic data, years of diabetes prior to transplant, months of dialysis prior to transplant, smoking, antihypertensive drugs intake, statins intake, cerebrovascular disease, myocardial ischemia, cholesterol levels and serum levels of creatinine, cystatin C, C-reactive protein and albumin were analyzed. Analysis of patients as well as kidney and pancreatic grafts survival was performed. Data were analyzed by SPSS version 27with significance at p &lt; 0.05.  Results:  Of the total of 216 patients included in the analysis with mean age of 46.01 ± 0.48 years, 32 patients (14,8%) developed symptomatic PAD and 23 patients (10,6%) critical limb ischemia. The major amputation rate in this subgroup was 26,1%. Patients with PAD were characterized by higher levels of LDL-C prior to transplant (p = 0.040), which were associated with a 1.011-fold higher risk of developing the disease. Higher levels of HbA1c 6 months and 3 years after transplant were also present among PAD patients (p = 0.033 and p = 0.022), associated with a respectively 1.512- fold and 1.334-fold higher risk of developing the disease. Patients with PAD had also higher levels of Cystatin C 5 years after transplant (p = 0.015) providing a 2.405-fold higher risk of developing the disease. Additionally, myocardial ischemia was also more prevalent among patients with PAD (p = 0.037) inducing a 3.220-fold higher risk of developing the disease. Survival analysis demonstrated a trend towards lower survival and lower renal graft survival in patients with PAD.  Conclusion:  Poor metabolic control appears to be associated with the development of symptomatic PAD. Elevated levels of cystatin C were also associated with PAD and this can be an independent marker of progression of disease. Also, this study demonstrated that patients with myocardial ischemia were at higher risk of developing PAD.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução:  O risco de doença arterial periférica (DAP) encontra-se significativamente aumentado nos doentes com diabetes mellitus tipo 1 que desenvolvem doença renal crônica. O transplante reno-pancreático assume-se como uma opção promissora para esses doentes, corrigindo ambas as disfunções. Os fatores de risco tradicionais para DAP estão bem definidos na população em geral. No entanto, em pacientes submetidos a transplante reno-pancreático a sua influência não se encontra caracterizada.  Objetivo:  O objetivo deste estudo foi identificar fatores de risco que influenciassem o desenvolvimento e progressão da DAP em doentes submetidos a transplante reno-pancreático e avaliar os resultados nessa população.  Métodos:  Estudo retrospetivo observacional de 229 doentes com diabetes mellitus tipo 1 e doença renal em estadio terminal submetidos a transplante simultâneo rim-pâncreas. Os dados demográficos, tempo de duração de diabetes antes do transplante, meses de diálise antes do transplante, tabagismo, medicação anti-hipertensora, estatinas, doença cerebrovascular, isquemia miocárdica, níveis de colesterol e níveis séricos de creatinina, cistatina C, proteína C reativa e albumina foram analisados. Foi realizada análise da sobrevida dos pacientes e dos enxertos renais e pancreáticos. Os dados foram analisados pelo SPSS versão 27 com significância em p &lt;0,05.  Resultados:  Do total de 216 pacientes incluídos na análise com média de idade de 46,01 ± 0,48 anos, 32 doentes (14,8%) desenvolveram DAP sintomática e 23 pacientes (10,6%) isquemia crítica de membro. A taxa de amputação major neste subgrupo foi de 26,1%. Os doentes com DAP foram caracterizados por níveis mais elevados de LDL-C antes do transplante (p = 0,040), que foram associados a um risco 1,011 vezes maior de desenvolver a doença. Níveis mais elevados de HbA1c 6 meses e 3 anos após o transplante também estavam presentes entre os doentes com DAP (p = 0,033 ep = 0,022), associados a um risco respectivamente 1,512 e 1,334 vezes maior de desenvolver a doença. Doentes com DAP foram também caracterizados por níveis mais elevados de cistatina C 5 anos após o transplante (p = 0,015), proporcionando um risco 2,405 vezes maior de desenvolver a doença. Além disso, a isquemia miocárdica também foi mais prevalente entre os doentes com DAP (p = 0,037), induzindo um risco 3,220 vezes maior de desenvolver a doença. A análise de sobrevida demonstrou uma tendência de menor sobrevida e menor sobrevida do enxerto renal em pacientes com DAP.  Conclusão:  O controle metabólico deficitário parece estar associado ao desenvolvimento de DAP sintomática nesta população. Níveis elevados de cistatina C também foram associados ao desenvolvimento de DAP, podendo ser um marcador independente de progressão da doença. Além disso, este estudo demonstrou que doentes com isquemia miocárdica apresentavam maior risco de desenvolver DAP.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Peripheral arterial disease]]></kwd>
<kwd lng="en"><![CDATA[Risk factors]]></kwd>
<kwd lng="en"><![CDATA[Type 1 diabetes mellitus]]></kwd>
<kwd lng="en"><![CDATA[Pancreas transplantation]]></kwd>
<kwd lng="en"><![CDATA[Kidney transplantation]]></kwd>
<kwd lng="pt"><![CDATA[Doença arterial periférica]]></kwd>
<kwd lng="pt"><![CDATA[Fatores de risco]]></kwd>
<kwd lng="pt"><![CDATA[Diabetes mellitus tipo 1]]></kwd>
<kwd lng="pt"><![CDATA[Transplante de pâncreas]]></kwd>
<kwd lng="pt"><![CDATA[Transplante de rim]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fowkes]]></surname>
<given-names><![CDATA[FG]]></given-names>
</name>
<name>
<surname><![CDATA[Aboyans]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Fowkes]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
<name>
<surname><![CDATA[McDermott]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Sampson]]></surname>
<given-names><![CDATA[UK]]></given-names>
</name>
<name>
<surname><![CDATA[Criqui]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Peripheral artery disease epidemiology and global perspectives]]></article-title>
<source><![CDATA[Nat Rev Cardiol]]></source>
<year>2017</year>
<volume>14</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>156-70</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Norgren]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Hiatt]]></surname>
<given-names><![CDATA[WR]]></given-names>
</name>
<name>
<surname><![CDATA[Dormandy]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)]]></article-title>
<source><![CDATA[Eur J Vasc Endovasc Surg]]></source>
<year>2007</year>
<volume>33</volume>
<numero>^s1</numero>
<issue>^s1</issue>
<supplement>1</supplement>
<page-range>S1-75</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Edmonds]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Vascular disease in the lower limb in type 1 diabetes]]></article-title>
<source><![CDATA[Cardiovasc Endocrinol Metab]]></source>
<year>2019</year>
<volume>8</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>39-46</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jiang]]></surname>
<given-names><![CDATA[AT]]></given-names>
</name>
<name>
<surname><![CDATA[Rowe]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Sener]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Luke]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Simultaneous pancreas-kidney transplantation The role in the treatment of type 1 diabetes and end-stage renal disease]]></article-title>
<source><![CDATA[Can Urol Assoc J]]></source>
<year>2014</year>
<volume>8</volume>
<numero>3-4</numero>
<issue>3-4</issue>
<page-range>135-8</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jenssen]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Hartmann]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Birkeland]]></surname>
<given-names><![CDATA[KI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Long-term diabetes complications after pancreas transplantation]]></article-title>
<source><![CDATA[Curr Opin Organ Transplant]]></source>
<year>2017</year>
<volume>22</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>382-8</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sucher]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Rademacher]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Jahn]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of simultaneous pancreas-kidney transplantation and kidney transplantation alone on the outcome of peripheral vascular diseases]]></article-title>
<source><![CDATA[BMC Nephrol]]></source>
<year>2019</year>
<volume>20</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>453</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[American Diabetes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Peripheral arterial disease in people with diabetes]]></article-title>
<source><![CDATA[Diabetes Care]]></source>
<year>2003</year>
<volume>26</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>3333-41</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aguiar]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Alegria]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Bonadonna]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A review of the evidence on reducing macrovascular risk in patients with atherogenic dyslipidaemia A report from an expert consensus meeting on the role of fenofibrate-statin combination therapy]]></article-title>
<source><![CDATA[Atheroscler Suppl]]></source>
<year>2015</year>
<volume>19</volume>
<page-range>1-12</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Diehm]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Shang]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Silvestro]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Association of cardiovascular risk factors with pattern of lower limb atherosclerosis in 2659 patients undergoing angioplasty]]></article-title>
<source><![CDATA[Eur J Vasc Endovasc Surg]]></source>
<year>2006</year>
<volume>31</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>59-63</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fowkes]]></surname>
<given-names><![CDATA[FG]]></given-names>
</name>
<name>
<surname><![CDATA[Rudan]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Rudan]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2013</year>
<volume>382</volume>
<numero>9901</numero>
<issue>9901</issue>
<page-range>1329-40</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aboyans]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Criqui]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
<name>
<surname><![CDATA[Denenberg]]></surname>
<given-names><![CDATA[JO]]></given-names>
</name>
<name>
<surname><![CDATA[Knoke]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
<name>
<surname><![CDATA[Ridker]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
<name>
<surname><![CDATA[Fronek]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Risk factors for progression of peripheral arterial disease in large and small vessels]]></article-title>
<source><![CDATA[Circulation]]></source>
<year>2006</year>
<volume>113</volume>
<numero>22</numero>
<issue>22</issue>
<page-range>2623-9</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Poulsen]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
<name>
<surname><![CDATA[Henriksen]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Dahl]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Myocardial ischemia, carotid, and peripheral arterial disease and their interrelationship in type 2 diabetes patients]]></article-title>
<source><![CDATA[J Nucl Cardiol]]></source>
<year>2009</year>
<volume>16</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>878-87</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hoe]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Koh]]></surname>
<given-names><![CDATA[WP]]></given-names>
</name>
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Sum]]></surname>
<given-names><![CDATA[CF]]></given-names>
</name>
<name>
<surname><![CDATA[Lim]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
<name>
<surname><![CDATA[Tavintharan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Predictors of decrease in ankle-brachial index among patients with diabetes mellitus]]></article-title>
<source><![CDATA[Diabet Med]]></source>
<year>2012</year>
<volume>29</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>e304-7</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kowall]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Erbel]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Moebus]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lehmann]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Kroger]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Stang]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Decline in ankle-brachial index is stronger in poorly than in well controlled diabetes Results from the Heinz Nixdorf Recall cohort study]]></article-title>
<source><![CDATA[Atherosclerosis]]></source>
<year>2019</year>
<volume>284</volume>
<page-range>37-43</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[IT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mean and variability of annual haemoglobin A1c are associated with high-risk peripheral artery disease]]></article-title>
<source><![CDATA[Diab Vasc Dis Res]]></source>
<year>2020</year>
<volume>17</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1479164120909030</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tasoglu]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Sert]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Colak]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Uzun]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Songur]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ecevit]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neutrophil-lymphocyte ratio and the platelet-lymphocyte ratio predict the limb survival in critical limb ischemia]]></article-title>
<source><![CDATA[Clin Appl Thromb Hemost]]></source>
<year>2014</year>
<volume>20</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>645-50</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[LY]]></given-names>
</name>
<name>
<surname><![CDATA[Han]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[LL]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[JX]]></given-names>
</name>
<name>
<surname><![CDATA[Dou]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pathophysiology of peripheral arterial disease in diabetes mellitus]]></article-title>
<source><![CDATA[J Diabetes]]></source>
<year>2017</year>
<volume>9</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>133-40</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fatemi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Acosta]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gottsater]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Copeptin, B-type natriuretic peptide and cystatin C are associated with incident symptomatic PAD]]></article-title>
<source><![CDATA[Biomarkers]]></source>
<year>2019</year>
<volume>24</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>615-21</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[O&amp;apos;Hare]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Newman]]></surname>
<given-names><![CDATA[AB]]></given-names>
</name>
<name>
<surname><![CDATA[Katz]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cystatin C and incident peripheral arterial disease events in the elderly results from the Cardiovascular Health Study]]></article-title>
<source><![CDATA[Arch Intern Med]]></source>
<year>2005</year>
<volume>165</volume>
<numero>22</numero>
<issue>22</issue>
<page-range>2666-70</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yap]]></surname>
<given-names><![CDATA[YS]]></given-names>
</name>
<name>
<surname><![CDATA[Chuang]]></surname>
<given-names><![CDATA[HY]]></given-names>
</name>
<name>
<surname><![CDATA[Chien]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Tai]]></surname>
<given-names><![CDATA[YK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Relationship between peripheral artery disease and combined albuminuria and low estimated glomerular filtration rate among elderly patients with type 2 diabetes mellitus]]></article-title>
<source><![CDATA[Diab Vasc Dis Res]]></source>
<year>2014</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>41-7</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mahmood]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Levy]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Vasan]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Framingham Heart Study and the epidemiology of cardiovascular disease a historical perspective]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2014</year>
<volume>383</volume>
<numero>9921</numero>
<issue>9921</issue>
<page-range>999-1008</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Khankan]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
<name>
<surname><![CDATA[Maeda]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Osuga]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Murakami]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Nakamura]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Post-kidney transplantation iliac artery stenosis due to iatrogenic injury case report]]></article-title>
<source><![CDATA[Cardiovasc Intervent Radiol]]></source>
<year>2003</year>
<volume>26</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>186-8</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
