1647-2160
1647-2160
S1647-21602025000200073
10.19131/rpesm.403
Madeira
Portugal
Portugal
00
12
2025
00
12
2025
34
73
92
[
2022
]
[
2021
10
1-9
]
[
2015
]
[
2020
16
1-8
]
[
2012
3
17-27
]
[
2023
20
2-16
]
[
2024
331
1-8
]
[
2019
14
1-16
]
[
European Union Drugs Agency
2023
]
[
2022
2
espec 11
espec 11
9
]
[
2012
12
81
]
[
2021
12
1-14
]
[
1997
166
182-6
]
[
2012
67
231-43
]
[
2019
13
15-33
]
[
2021
27
75-82
]
[
2017
12
]
[
2014
67
505-11
]
[
2021
18
]
[
2019
14
61-74
]
[
2016
23
25-35
]
[
2018
]
[
2019
32
279-88
]
[
2023
46
22-6
]
[
2022
6
1-8
]
[
2000
15
259-67
]
[
2020
30
1-19
]
[
OECD
2021
]
[
OECD
2023
]
[
2015
39
503-11
]
[
2023
]
[
2019
17
38-44
]
[
2020
6
223-34
]
[
2023
31
33-52
]
[
2022
4
49-73
]
[
2013
3
170-81
]
[
2013
19
1901-9
]
[
2016
30
30
103-19
]
[
2021
37
121
]
[
2022
53
1-10
]
[
2018
5
136-49
]
[
2014
]
[
2022
35
249-56
]
[
2019
204
]
[
2010
18
535-42
]