<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2182-2395</journal-id>
<journal-title><![CDATA[Revista da Sociedade Portuguesa de Dermatologia e Venereologia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Soc Port Dermatol Venereol]]></abbrev-journal-title>
<issn>2182-2395</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Dermatologia e Venereologia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2182-23952021000200026</article-id>
<article-id pub-id-type="doi">10.29021/spdv.79.2.1370</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Opções Terapêuticas Farmacológicas na Acne vulgar]]></article-title>
<article-title xml:lang="en"><![CDATA[Pharmacological Therapies in Acne vulgaris]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Freitas]]></surname>
<given-names><![CDATA[Tomás Esteves Caseiro Mendes de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velho]]></surname>
<given-names><![CDATA[Glória Maria Cardoso da Cunha]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Hospitalar do Porto Instituto Ciências Biomédicas Abel Salazar ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>79</volume>
<numero>2</numero>
<fpage>26</fpage>
<lpage>32</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2182-23952021000200026&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2182-23952021000200026&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2182-23952021000200026&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  A acne vulgar é uma patologia crónica da unidade pilossebácea caracterizada por polimorfismo cutâneo, sendo das mais prevalentes na adolescência. Pode originar sequelas físicas, como cicatrizes desfigurantes, e psicológicas, nomeadamente diminuição da qualidade de vida e função psicossocial. Assim, torna-se fundamental uma estratégia terapêutica eficaz de modo a promover a sua resolução e, simultaneamente, minimizar a presença destas sequelas. Atualmente, os fármacos disponíveis são diversos, obrigando, na sua seleção, à avaliação biopsicossocial do doente. Estudos recentes têm apontado novos agentes terapêuticos promissores, nomeadamente alternativas aos retinóides tópicos, isotretinoína oral, antiandrogénios orais e antibióticos. Estes poderão permitir uma redução da resistência antibiótica e consequente aumento da eficácia com redução substancial dos efeitos adversos. O melhor perfil de segurança e tolerabilidade poderá otimizar a abordagem terapêutica atual.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Acne vulgaris is a chronic disease of the pilosebaceous unit characterized by cutaneous polymorphism, representing one of the most prevalent diseases in adolescence. It can lead to physical sequelae, such as disfiguring scars, and psychological, with a decreased quality of life and psychosocial function. Thus, an effective therapeutic strategy is essential in order to promote its resolution and minimize sequelae. Nowadays, there are several available drugs, but their choice requires biopsychosocial assessment of the patient. Recent studies have shown promising new therapeutic agents, as alternatives to topical retinoids, oral isotretinoin, oral antiandrogens, and antibiotics, which would allow a reduction in antibiotic resistance and a consequent increase in efficacy with a substantial reduction in adverse effects. Increasing security and tolerability of new drugs would improve the current approach of acne treatment.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Acne Vulgaris/drug therapy]]></kwd>
<kwd lng="en"><![CDATA[Administration, Cutaneous]]></kwd>
<kwd lng="en"><![CDATA[Administration, Oral]]></kwd>
<kwd lng="en"><![CDATA[Dermatologic Agents.]]></kwd>
<kwd lng="pt"><![CDATA[Acne Vulgar/tratamento farmacológico]]></kwd>
<kwd lng="pt"><![CDATA[Administração Cutânea]]></kwd>
<kwd lng="pt"><![CDATA[Administração Oral]]></kwd>
<kwd lng="pt"><![CDATA[Fármacos Dermatológicos.]]></kwd>
</kwd-group>
</article-meta>
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