<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2182-2395</journal-id>
<journal-title><![CDATA[Revista da Sociedade Portuguesa de Dermatologia e Venereologia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Soc Port Dermatol Venereol]]></abbrev-journal-title>
<issn>2182-2395</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Dermatologia e Venereologia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2182-23952021000300034</article-id>
<article-id pub-id-type="doi">10.29021/spdv.79.3.1373</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Isotretinoin, Acne and Depression: A Prospective Controlled Study]]></article-title>
<article-title xml:lang="pt"><![CDATA[Isotretinoína, Acne e Depressão: Um Estudo Prospectivo Controlado]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Langer]]></surname>
<given-names><![CDATA[Laura V]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Prim]]></surname>
<given-names><![CDATA[Lucas]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Skare]]></surname>
<given-names><![CDATA[Thelma]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Wrublevski]]></surname>
<given-names><![CDATA[Virginia X]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nisihara]]></surname>
<given-names><![CDATA[Renato]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Mackenzie Evangelical School of Medicine Paraná  ]]></institution>
<addr-line><![CDATA[Curitiba ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Positivo University Medicine Department ]]></institution>
<addr-line><![CDATA[Curitiba ]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>09</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>09</month>
<year>2021</year>
</pub-date>
<volume>79</volume>
<numero>3</numero>
<fpage>34</fpage>
<lpage>38</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2182-23952021000300034&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2182-23952021000300034&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2182-23952021000300034&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Acne and isotretinoin, one of its treatment, have been linked to the occurrence of depression. Our aim was to study if isotretinoin is associated with depression in a sample of acne patients followed for 6 months comparing them with acne patients under other treatment modalities and control patients without acne.  Methods:  One hundred individuals were included: 50 controls and 50 with acne (24 using and 26 not using isotretinoin). Patients and controls answered the Beck Depression Inventory (BDI) and the 12 Item-Short Form Health Survey for quality of life (SF-12). Acne patients repeated this evaluation in 90 and 180 days.  Results:  No differences were found between controls and acne patients regarding BDI results but controls performed worse in the SF-12 mental domain (p=0.004). No differences were found within the acne group between those treated and not treated with isotretinoin in the comparison of the BDI and SF-12 (mental and physical domains) in days 0. 90 and 180 (all with p&gt;0.05).  Conclusion:  In this small sample isotretinoin treatment showed to be safe regarding the occurrence of depression.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  Introdução:  Depressão tem sido atribuída à acne e a um dos seus tratamentos, a isotretinoína. O nosso objetivo foi estudar se o uso da isotretinoína está associado com a depressão numa amostra de pacientes com acne acompanhados por 6 meses, comparando-se os com pacientes com acne sem este tratamento e com indivíduos de um gripo controlo, sem acne.  Métodos:  Cem indivíduos foram incluídos: 50 controles e 50 com acne (24 usando e 26 não usando isotretinoína). Pacientes e controles responderam ao Inventário de Depressão de Beck (IDB) e ao SF-12 (12-Item Short-Form Health Survey ou Forma curta com 12 questões do questionário de Pesquisa de Saúde). Pacientes com acne repetiram estes questionários após 90 e 180 dias.  Resultados:  Indivíduos controles e pacientes com acne não mostraram diferenças quando os valores do IDB foram comparados, mas os controles tiveram um pior desempenho no SF-12 - domínio mental (p=0,004). Também não foi possível verificar diferenças entre os grupos de acne tratados e não tratados com isotretinoína quanto ao IDB e ao SF-12 nos dias 0, 90 e 180 (todos com p&gt;0,05).  Conclusão:  Nesta pequena amostra o tratamento com isotretinoína se mostrou seguro no que concerne à ocorrência de depressão.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Acne Vulgaris/drug therapy]]></kwd>
<kwd lng="en"><![CDATA[Depression/chemically induced]]></kwd>
<kwd lng="en"><![CDATA[Isotretinoin/adverse effects]]></kwd>
<kwd lng="pt"><![CDATA[Acne Vulgar/tratamento farmacológico]]></kwd>
<kwd lng="pt"><![CDATA[Depressão/induzida quimicamente]]></kwd>
<kwd lng="pt"><![CDATA[Isotretinoína/efeitos adversos.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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