<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2182-5173</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Medicina Geral e Familiar]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Med Geral Fam]]></abbrev-journal-title>
<issn>2182-5173</issn>
<publisher>
<publisher-name><![CDATA[Associação Portuguesa de Medicina Geral e Familiar]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2182-51732021000300223</article-id>
<article-id pub-id-type="doi">10.32385/rpmgf.v37i3.12820</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Proton pumps inhibitors in gastroesophageal reflux disease: what is the best regimen? An evidence-based review.]]></article-title>
<article-title xml:lang="pt"><![CDATA[Inibidores das bombas de protões na doença de refluxo gastroesofágico: qual o melhor regime? Uma revisão baseada na evidência.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Rui]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pinto]]></surname>
<given-names><![CDATA[Nuno Teles]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidade de Saúde Familiar de Valbom  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Unidade de Saúde Familiar de Fânzeres  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>37</volume>
<numero>3</numero>
<fpage>223</fpage>
<lpage>229</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2182-51732021000300223&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2182-51732021000300223&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2182-51732021000300223&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objectives:  Gastroesophageal reflux disease is one of the most common gastrointestinal diagnoses. This disorder causes many symptoms and may induce the development of Barret&#8217;s esophagus and esophageal adenocarcinoma. Proton pump inhibitors are the most used treatment and, usually, are prescribed for once-daily dosing before breakfast. However, many patients describe night-time symptoms, a period when an increase of basal gastric acid secretion occurs. Therefore, this evidence-based review was performed in order to understand which is the best regimen for proton pump inhibitor intake.  Methods:  The MeSH words &#8216;proton pump inhibitors&#8217;, &#8216;gastro-oesophageal reflux&#8217;, GERD, and pH were chosen to search for synopses, guidelines, meta-analysis, systematic reviews, and original papers, published after 2008 in the databases MEDLINE, National Guideline Clearinghouse, NHS Evidence, Canadian Medical Association, TRIP Database, The Cochrane Library, DARE and Bandolier in English, French, Spanish and Portuguese. A search in the Índex de Revistas Médicas Portuguesas with the words &#8220;inibidores das bombas de protões&#8221;, &#8220;refluxo gastroesofágico&#8221;, DRGE, and pH was also performed. The search retrieves 2,546 articles, from those, three were used in this review.  Results:  Three prospective studies that evaluate the effects of dosage and/or timing of proton pump inhibitors intake in gastric pH were obtained. These studies indicate that, in patients with predominant night-time symptoms, intake before dinner achieves better results than before breakfast. Additionally, doubling the dose reduces symptoms and the duration of pH lower than four.  Conclusion:  Symptom timing and patient compliance are crucial when choosing the therapeutic regimen. The timing of proton pumps inhibitors intake should be associated with the symptom&#8217;s timing; C-level of recommendation.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Objetivos:  A doença de refluxo gastroesofágico é um diagnóstico gastrointestinal comum, podendo causar vários sintomas e induzir o desenvolvimento de neoplasia esofágica. Os inibidores da bomba de protões são o tratamento de eleição, sendo normalmente tomados antes do pequeno-almoço. Contudo, muitos doentes indicam sintomas noturnos e, à noite, ocorre um aumento da secreção de ácido gástrico. Assim, este estudo foi realizado com o objetivo de compreender qual o melhor regime terapêutico para a toma destes fármacos.  Métodos:  Pesquisaram-se sinopses, meta-análises, revisões-sistemáticas, guidelines e trabalhos originais, publicados depois de 2008, nas bases de dados MEDLINE, National Guideline Clearinghouse, NHS Evidence, Canadian Medical Association, TRIP Database, The Cochrane Library, DARE e Bandolier, em inglês, francês, espanhol e português, usando os termos MeSH proton pump inhibitors, gastro-oesophageal reflux, GERD e pH. Também se pesquisou no Índex de Revistas Médicas Portuguesas, usando as expressões &#8220;inibidores das bombas de protões&#8221;, &#8220;refluxo gastroesofágico&#8221;, DRGE e pH. A pesquisa revelou 2.546 artigos e, destes, três foram incluídos nesta revisão.  Resultados:  Obtiveram-se três estudos prospetivos, que avaliaram os efeitos da dose e/ou timing da toma de inibidores da bomba de protões no pH gástrico. Estes estudos indicaram que a toma antes do jantar apresenta melhores resultados do que a toma antes do pequeno-almoço no refluxo gastroesofágico. Adicionalmente, duplicando a dose, verifica-se uma redução dos sintomas e do período de tempo com pH menor que quatro.  Conclusão:  O período dos sintomas e a compliance dos pacientes são cruciais aquando da escolha do momento de toma. O momento da toma dos inibidores da bomba de protões deve ter em consideração o período dos sintomas; nível de recomendação C.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Proton pump inhibitors]]></kwd>
<kwd lng="en"><![CDATA[Gastroesophageal reflux]]></kwd>
<kwd lng="en"><![CDATA[pH]]></kwd>
<kwd lng="pt"><![CDATA[Inibidores da bomba de protões]]></kwd>
<kwd lng="pt"><![CDATA[Refluxo gastroesofágico]]></kwd>
<kwd lng="pt"><![CDATA[pH]]></kwd>
</kwd-group>
</article-meta>
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