<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2182-5173</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Medicina Geral e Familiar]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Med Geral Fam]]></abbrev-journal-title>
<issn>2182-5173</issn>
<publisher>
<publisher-name><![CDATA[Associação Portuguesa de Medicina Geral e Familiar]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2182-51732021000500436</article-id>
<article-id pub-id-type="doi">10.32385/rpmgf.v37i5.12962</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Hipericão na perturbação depressiva: revisão crítica de autor]]></article-title>
<article-title xml:lang="en"><![CDATA[Hypericum in depressive disorder: a critical review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[Tiago da Cunha]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Paraíso]]></surname>
<given-names><![CDATA[Filipa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[Daniela Marafona]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Coelho]]></surname>
<given-names><![CDATA[Maria João]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,ACeS Tâmega III - Vale do Sousa Norte USF Hygeia ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,ACeS Tâmega III - Vale do Sousa Norte USF Santa Luzia ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,ACeS Tâmega II - Vale do Sousa Sul USF Salvador Lordelo ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,ACeS Tâmega III - Vale do Sousa Norte USF Freamunde ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>10</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>10</month>
<year>2021</year>
</pub-date>
<volume>37</volume>
<numero>5</numero>
<fpage>436</fpage>
<lpage>444</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2182-51732021000500436&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2182-51732021000500436&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2182-51732021000500436&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Objetivos:  Rever a evidência existente quanto à eficácia, tolerabilidade e segurança do hipericão no tratamento da perturbação depressiva (PD).  Fontes de dados:  NICE, Canadian Medical Association Infobase, PubMed - Clinical Queries, The Cochrane Library, BMJ, Bandolier e DARE - Centre for Reviews and Dissemination.  Métodos: Foi realizada a pesquisa de artigos científicos em plataformas online de medicina baseada na evidência, com as palavras-chave Hypericum e Depressive Disorder. A seleção dos artigos foi feita com base no título, ano de publicação e resumo.  Resultados: Foram incluídas nesta revisão duas normas de orientação clínica (NOC), três meta-análises (MA), duas revisões sistemáticas (RS) e um artigo original (AO). Uma NOC referiu que o hipericão pode ser usado como primeira linha na PD major ligeira a moderada e como tratamento adjuvante de segunda linha na PD major moderada a grave. A outra NOC não aconselha o seu uso. As MA e as RS concluíram que o hipericão apresenta uma eficácia superior ao placebo no tratamento da PD, sendo que duas MA e as RS acrescentaram que não há aumento dos efeitos adversos. As duas RS referiram o risco de interações com outros fármacos. O AO também afirma a eficácia do hipericão nas mulheres na pós-menopausa.  Conclusão:  Existe evidência quanto à eficácia do hipericão na PD ligeira a moderada. Os dados disponíveis parecem ser consistentes quanto à sua boa tolerabilidade, mas também quanto ao risco de interações com outros fármacos. As limitações da recomendação prendem-se essencialmente com o facto dos mecanismos de ação não estarem completamente esclarecidos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objectives:  Review the evidence regarding the effectiveness, tolerability, and safety of hypericum in the treatment of depressive disorder (DD).  Data sources:  NICE, Canadian Medical Association Infobase, PubMed - Clinical Queries, The Cochrane Library, BMJ, Bandolier, and DARE - Centre for Reviews and Dissemination.  Methods: The research for scientific articles was performed on online Evidence-Based Medicine platforms, with the keywords &#8216;Hypericum&#8217; and &#8216;Depressive Disorder&#8217;. Articles were selected based on title, year of publication, and abstract.  Results:  Two clinical guidelines (CG), three meta-analyses (MA), two systematic reviews (SR), and one original article (OA) were included in this review. One CG reported that hypericum can be used as first-line in mild to moderate major DD and as an adjuvant treatment of second-line in moderate to severe major DD. Another CG does not support the use. All of MA and SR conclude that hypericum is more effective than placebo in the treatment of DD, with two MA and two SR added that there is no increase of adverse effects. The two SR mentioned the risk of interactions with other drugs. The OA also affirms the effectiveness of hypericum in postmenopausal women.  Conclusion:  There is evidence regarding the efficacy of hypericum in mild to moderate DD. The available data appears to be consistent with its good tolerability, but also in terms of the risk of interactions with other drugs. The limitations of the recommendation are essentially due to the mechanisms of action that are not fully understood.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Hipericão]]></kwd>
<kwd lng="pt"><![CDATA[Perturbação depressiva]]></kwd>
<kwd lng="en"><![CDATA[Hypericum]]></kwd>
<kwd lng="en"><![CDATA[Depressive disorder]]></kwd>
</kwd-group>
</article-meta>
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