<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2182-5173</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Medicina Geral e Familiar]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Med Geral Fam]]></abbrev-journal-title>
<issn>2182-5173</issn>
<publisher>
<publisher-name><![CDATA[Associação Portuguesa de Medicina Geral e Familiar]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2182-51732022000200198</article-id>
<article-id pub-id-type="doi">10.32385/rpmgf.v38i2.13189</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Hiperpigmentação da mucosa oral como apresentação da síndroma de Laugier-Hunziker: um relato de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Oral mucosa hyperpigmentation as a presentation of Laugier-Hunziker syndrome: a case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[Rita Fernandes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Coelho]]></surname>
<given-names><![CDATA[Sara Alcobia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gonçalves]]></surname>
<given-names><![CDATA[Maria Inês Queiroz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gil]]></surname>
<given-names><![CDATA[Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,ARS Centro USF Mondego ]]></institution>
<addr-line><![CDATA[Coimbra ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,ARS Centro UCSP Juíz de Fora ]]></institution>
<addr-line><![CDATA[Mortágua ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>04</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>04</month>
<year>2022</year>
</pub-date>
<volume>38</volume>
<numero>2</numero>
<fpage>198</fpage>
<lpage>202</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2182-51732022000200198&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2182-51732022000200198&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2182-51732022000200198&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução: As lesões pigmentadas da mucosa oral podem corresponder a alterações locais ou a manifestações de doença sistémica. Importa conhecer as principais etiologias destas lesões para assim identificar aquelas com necessidade de intervenção e tratamento atempado específico.  Descrição do caso: Relata-se o caso de uma mulher de 89 anos que, numa consulta de vigilância de diabetes, refere lesões pigmentadas na língua, com meses de evolução, sem dor ou outra sintomatologia associada. Foi referenciada a consulta de dermatologia para estudo, onde foi realizada biópsia de uma das lesões, cujo resultado foi compatível com mácula melanótica. Perante o quadro clínico e os achados anatomopatológicos foi considerado o diagnóstico de síndroma de Laugier-Hunziker (SLH). A utente foi informada da benignidade do quadro e da ausência de necessidade de tratamento.  Comentário: A SLH é uma doença mucocutânea, benigna, de caráter adquirido, que se caracteriza por múltiplas máculas hiperpigmentadas, mais frequentemente presentes na mucosa oral ou lábios e configura um diagnóstico de exclusão. O artigo pretende relatar uma síndroma rara, com manifestação dermatológica, e abordar o diagnóstico diferencial de lesões hiperpigmentadas da mucosa oral.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  Pigmented lesions of the oral cavity can be caused by local changes or configure manifestation of systemic disease. It is important to recognize the main etiologies of these lesions in order to identify, timely, the need for intervention and treatment.  Case description:  We report a case of an 89-year-old woman who, in a diabetes surveillance consultation, complained of the pigmented tongue, with months of evolution, without pain or other associated symptoms. The patient was referred to the dermatologist, where a biopsy of one of the lesions was performed, which revealed a melanotic macula of the oral mucosa. Considering clinical features and histological findings, the diagnosis of Laugier-Hunziker syndrome (LHS) was done. The patient was informed of the benignity of the condition and the absence of the need for treatment.  Comment:  LHS is a benign mucocutaneous disease, of acquired character, characterized by multiple hyperpigmented macules, most often present in the oral mucosa or lips. Although rare, it is a benign and acquired disease and constitutes a diagnosis of exclusion. The article intends to report a rare syndrome with dermatological manifestations and to address the differential diagnosis of hyperpigmented lesions of the oral mucosa.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Síndroma de Laugier-Hunziker]]></kwd>
<kwd lng="pt"><![CDATA[Hiperpigmentação]]></kwd>
<kwd lng="pt"><![CDATA[Mucosa oral, Anormalidades]]></kwd>
<kwd lng="pt"><![CDATA[Relato de caso]]></kwd>
<kwd lng="en"><![CDATA[Laugier-Hunziker syndrome]]></kwd>
<kwd lng="en"><![CDATA[Hyperpigmentation]]></kwd>
<kwd lng="en"><![CDATA[Mouth mucosa, Abnormalities]]></kwd>
<kwd lng="en"><![CDATA[Case report]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sreeja]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Ramakrishnan]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Vijayalakshmi]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Devi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Aesha]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Vijayabanu]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Oral pigmentation a review]]></article-title>
<source><![CDATA[J Pharm Bioallied Sci]]></source>
<year>2015</year>
<volume>7</volume>
<numero>^s2</numero>
<issue>^s2</issue>
<supplement>2</supplement>
<page-range>S403-8</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rosebush]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Briody]]></surname>
<given-names><![CDATA[AN]]></given-names>
</name>
<name>
<surname><![CDATA[Cordell]]></surname>
<given-names><![CDATA[KG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Black and brown non-neoplastic pigmentation of the oral mucosa]]></article-title>
<source><![CDATA[Head Neck Pathol]]></source>
<year>2019</year>
<volume>13</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>47-55</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[LL]]></given-names>
</name>
<name>
<surname><![CDATA[Mariano]]></surname>
<given-names><![CDATA[AV]]></given-names>
</name>
<name>
<surname><![CDATA[Rodrigues]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Reyes]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Você conhece esta síndrome ?]]></article-title>
<source><![CDATA[An Bras Dermatol]]></source>
<year>2010</year>
<volume>85</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>751-3</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sabongi]]></surname>
<given-names><![CDATA[RG]]></given-names>
</name>
<name>
<surname><![CDATA[Dias]]></surname>
<given-names><![CDATA[NP]]></given-names>
</name>
<name>
<surname><![CDATA[Duck]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Sabongi]]></surname>
<given-names><![CDATA[VP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síndrome de Laugier-Hunziker]]></article-title>
<source><![CDATA[Rev Fac Ciênc Méd Sorocaba]]></source>
<year>2012</year>
<volume>14</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>67-70</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Mafra]]></surname>
<given-names><![CDATA[RP]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[PT]]></given-names>
</name>
<name>
<surname><![CDATA[Medeiros]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Pinto]]></surname>
<given-names><![CDATA[LP]]></given-names>
</name>
<name>
<surname><![CDATA[Silveira]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Oral pigmentations in Laugier-Hunziker syndrome a case report and review of diagnostic criteria]]></article-title>
<source><![CDATA[J Bras Patol e Med Lab]]></source>
<year>2018</year>
<volume>54</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>52-6</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lampe]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
<name>
<surname><![CDATA[Hampton]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Woodford-Richens]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Tomlinson]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Lawrence]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Douglas]]></surname>
<given-names><![CDATA[FS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Laugier-Hunziker syndrome an important differential diagnosis for Peutz-Jeghers syndrome]]></article-title>
<source><![CDATA[J Med Genet]]></source>
<year>2003</year>
<volume>40</volume>
<numero>6</numero>
<issue>6</issue>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sachdeva]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sachdeva]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kapoor]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Laugier-Hunziker syndrome a rare cause of oral and acral pigmentation]]></article-title>
<source><![CDATA[J Cutan Aesthet Surg]]></source>
<year>2011</year>
<volume>4</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>58-60</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Siponen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Salo]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Idiopathic lenticular mucocutaneous pigmentation (Laugier-Hunziker syndrome) a report of a case]]></article-title>
<source><![CDATA[Oral Surg Oral Med Oral Pathol Oral Radiol Endod]]></source>
<year>2003</year>
<volume>96</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>288-92</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nayak]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
<name>
<surname><![CDATA[Kotrashetti]]></surname>
<given-names><![CDATA[VS]]></given-names>
</name>
<name>
<surname><![CDATA[Hosmani]]></surname>
<given-names><![CDATA[JV]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Laugier-Hunziker syndrome]]></article-title>
<source><![CDATA[J Oral Maxillofac Pathol]]></source>
<year>2012</year>
<volume>16</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>245-50</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gerbig]]></surname>
<given-names><![CDATA[AW]]></given-names>
</name>
<name>
<surname><![CDATA[Hunziker]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Idiopathic lenticular mucocutaneous pigmentation or Laugier-Hunziker syndrome with atypical features]]></article-title>
<source><![CDATA[Arch Dermatol]]></source>
<year>1996</year>
<volume>132</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>844-5</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
