2182-5173 2182-5173 S2182-51732022000500474 10.32385/rpmgf.v38i5.13422 Portugal Portugal Portugal Portugal Portugal 31 10 2022 31 10 2022 38 5 474 486

1 2011 106 12 12 2086-109 2 2005 9th 515-24 3 2012 91 1 1 24-31 4 2017 17 4 4 493-507 5 2017 12 4 4 6 1998 44 799-808 7 2003 31 3 3 224-8 8 1997 7 8 8 568-74 9 2019 19 1 1 317 10 2012 345 11 2005 66 ^s2 ^s2 2 9-13 12 2020 11 344 13 2014 348 g1996 14 INFARMED 2017 15 INFARMED 2019 16 1994 44 378 378 5-8 17 van de Lisdonk EH.van Balkom AJ.van den Hoogen HJ 2005 78 1 1 49-56 18 2020 34 6 6 539-45 19 1997 6 1 1 14-8 20 2012 13 111 21 2020 4 1 1 22 2003 20 2 2 199-206 23 2014 204 6 6 471-9 24 2022 39 2 2 241-8 25 2019 35 4 4 305-12 26 2019 20 1 1 71 27 2011 12 23 28 Caldas de Almeida JM.Xavier M 2013 29 2006 19 3 3 239-46 30 2011 16 6 6 2841-52 31 2017 32 2011 6 42 33 2016 34 National Institute of Health and Care Excellence 2013 35 Direção-Geral da Saúde 2011 36 Direção-Geral da Saúde 2015 37 2018 64 5 5 339-51 38 All Wales Medicines Strategy Group 2016 39 2015 40 2018 3rd 41 R Foundation 2019 42 R Studio 2015 43 2015 44 2017 249 221-5 45 De las Cuevas C.Sanz E.De la Fuente JA.Cabrera C.Mateos A 1999 8 3 3 207-16 46 2019 4 1 1 27 47 2021 21 1 1 277 48 2007 31-45 49 2007 25 4 4 214-9 50 2015 15 417 51 2013 52 2010 10 321