<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2182-5173</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Medicina Geral e Familiar]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Med Geral Fam]]></abbrev-journal-title>
<issn>2182-5173</issn>
<publisher>
<publisher-name><![CDATA[Associação Portuguesa de Medicina Geral e Familiar]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2182-51732025000200158</article-id>
<article-id pub-id-type="doi">10.32385/rpmgf.v41i2.14134</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Bisalbuminemia, um traço familiar: relato de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Bisalbuminaemia, a family trait: case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Veloso]]></surname>
<given-names><![CDATA[Marta]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Braga]]></surname>
<given-names><![CDATA[Mariana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendes]]></surname>
<given-names><![CDATA[Mariana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Portugal]]></surname>
<given-names><![CDATA[Marta]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hatherly]]></surname>
<given-names><![CDATA[Rebeca]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,ULS Lisboa Ocidental USF Delta ]]></institution>
<addr-line><![CDATA[Paço d&#8217;Arcos ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,ULS Lisboa Ocidental USF Delta ]]></institution>
<addr-line><![CDATA[Paço d&#8217;Arcos ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<volume>41</volume>
<numero>2</numero>
<fpage>158</fpage>
<lpage>163</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2182-51732025000200158&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2182-51732025000200158&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2182-51732025000200158&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução:  A albumina sérica humana constitui a proteína sérica mais abundante no plasma, desempenhando múltiplas funções essenciais. Entre os vários polimorfismos na sua expressão encontra-se a bisalbuminemia. Este fenótipo pode surgir de forma hereditária, uma patologia genética relativamente rara, ou de forma transitória (secundária).  Descrição do caso:  Apresenta-se uma criança de quatro anos de idade, do sexo masculino, com um quadro de seletividade alimentar, sem alterações ao exame objetivo. Realizou avaliação analítica, que revelou anemia ferropénica e um padrão de bisalbuminemia na eletroforese de proteínas, sem outras alterações. Foi presumida a forma inata, com causa genética, tendo sido solicitada avaliação com eletroforese de proteínas à mãe, que mostrou a presença de um padrão idêntico, corroborando esta hipótese. Iniciou suplementação com ferro e em reavaliação confirmou-se a correção da anemia ferropénica e manutenção do padrão de bisalbuminemia.  Comentário:  A bisalbuminemia hereditária tem uma prevalência reduzida na população; no entanto, o reconhecimento deste padrão é de particular relevância na prática clínica, sobretudo no contexto dos cuidados de saúde primários. A identificação precoce desta variante benigna permite ao médico de família orientar o utente de forma adequada, esclarecendo a natureza genética e não patológica da condição, evitando intervenções desnecessárias.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  Human serum albumin is the most abundant serum protein in plasma and plays several essential roles. Among the various polymorphisms in its expression is bisalbuminaemia. This phenotype can be hereditary, a relatively rare genetic condition, or transient (secondary).  Case description:  We present a 4-year-old male child with food selectivity and no abnormalities on physical examination. An analytical assessment revealed iron deficiency anaemia and a protein electrophoresis pattern of bisalbuminaemia, with no other abnormalities. The innate form was presumed to be a genetic cause, and the mother was asked to undergo protein electrophoresis, which showed an identical pattern, corroborating this hypothesis. Iron supplementation was started, and a reassessment confirmed the ferropenic anaemia correction and the bisalbuminaemia pattern&#8217;s maintenance.  Comment:  Hereditary bisalbuminaemia has a low prevalence in the population, however recognising this pattern is particularly important in clinical practice, especially in the context of primary healthcare. Early identification of this benign variant allows the family doctor to guide the patient appropriately, clarifying the genetic and non-pathological nature of the condition and avoiding unnecessary interventions.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Eletroforese de proteínas]]></kwd>
<kwd lng="pt"><![CDATA[Albumina sérica]]></kwd>
<kwd lng="pt"><![CDATA[Bisalbuminemia]]></kwd>
<kwd lng="pt"><![CDATA[Relato de caso]]></kwd>
<kwd lng="en"><![CDATA[Blood protein electrophoresis]]></kwd>
<kwd lng="en"><![CDATA[Serum albumin]]></kwd>
<kwd lng="en"><![CDATA[Bisalbuminaemia]]></kwd>
<kwd lng="en"><![CDATA[Case report]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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