<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2183-1351</journal-id>
<journal-title><![CDATA[Acta Radiológica Portuguesa]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Radiol Port]]></abbrev-journal-title>
<issn>2183-1351</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Radiologia e Medicina Nuclear]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2183-13512026000100802</article-id>
<article-id pub-id-type="doi">10.25748/arp.42815</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Gadolinium Hypersensitivity: Review of Four Cases]]></article-title>
<article-title xml:lang="pt"><![CDATA[Hipersensibilidade ao Gadolínio: A Propósito de Quatro Casos Clínicos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gomes]]></surname>
<given-names><![CDATA[Margarida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[Sofia Cosme]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bernardino]]></surname>
<given-names><![CDATA[Ana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Figueiredo]]></surname>
<given-names><![CDATA[Pedro Samuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Maria Inês]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duarte]]></surname>
<given-names><![CDATA[Fátima Cabral]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidade Local de Saúde de Santa Maria EPE Hospital de Santa Maria Serviço de Imunoalergologia]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Dr. Nélio Mendonça Serviço de Imunoalergologia ]]></institution>
<addr-line><![CDATA[Funchal ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>01</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>01</month>
<year>2026</year>
</pub-date>
<volume>38</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2183-13512026000100802&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2183-13512026000100802&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2183-13512026000100802&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Immediate hypersensitivity reactions to gadolinium-based contrast agents are uncommon but can be life-threatening. We describe four cases of immediate hypersensitivity reactions to gadobutrol, including anaphylaxis. All patients underwent allergy work-up, with positive skin prick tests to gadobutrol. Two patients also demonstrated cross-reactivity to gadoteric acid. Disodium gadoxetate was tolerated in all cases in magnetic resonance. These findings highlight the importance of individualized allergy work-up to guide safe future imaging.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo As reações de hipersensibilidade imediata a meios de contraste à base de gadolínio são raras, mas potencialmente graves. Apresentamos uma série de quatro casos clínicos de reações de hipersensibilidade imediata ao gadobutrol, incluindo anafilaxia. Todos os doentes realizaram investigação alergológica com testes cutâneos, confirmando sensibilização ao gadobutrol. Dois apresentaram reatividade cruzada com ácido gadotérico. O gadoxetato dissódico foi tolerado em todos em ressonância magnética. Estes casos reforçam a importância do diagnóstico alergológico individualizado para orientar exames futuros com segurança.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Gadolínio]]></kwd>
<kwd lng="pt"><![CDATA[Reações de hipersensibilidade]]></kwd>
<kwd lng="pt"><![CDATA[Anafilaxia.]]></kwd>
<kwd lng="en"><![CDATA[Gadolinium]]></kwd>
<kwd lng="en"><![CDATA[Drug hypersensitivity]]></kwd>
<kwd lng="en"><![CDATA[Anaphylaxis.]]></kwd>
</kwd-group>
</article-meta>
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