<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2183-5985</journal-id>
<journal-title><![CDATA[Acta Portuguesa de Nutrição]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Port Nutr]]></abbrev-journal-title>
<issn>2183-5985</issn>
<publisher>
<publisher-name><![CDATA[Associação Portuguesa de Nutrição]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2183-59852021000100070</article-id>
<article-id pub-id-type="doi">10.21011/apn.2021.2413</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[ÁCIDO ARISTOLÓQUICO - NEFROPATIA E O CANCRO]]></article-title>
<article-title xml:lang="en"><![CDATA[ARISTOLOCHIC ACID - NEPHROPATHY AND CANCER]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Faria]]></surname>
<given-names><![CDATA[Bruna]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bispo]]></surname>
<given-names><![CDATA[Cátia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cordeiro]]></surname>
<given-names><![CDATA[Mariana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Baltazar]]></surname>
<given-names><![CDATA[Ana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Escola Superior de Tecnologia da Saúde do Instituto Politécnico de Coimbra  ]]></institution>
<addr-line><![CDATA[Coimbra ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>03</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>03</month>
<year>2021</year>
</pub-date>
<numero>24</numero>
<fpage>70</fpage>
<lpage>75</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2183-59852021000100070&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2183-59852021000100070&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2183-59852021000100070&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO O ácido aristolóquico é um composto natural tóxico, proveniente da família de uma herbácea perene, Aristolochia. Este pertence à família de ácidos nitrofenantrol carboxílicos e é uma mistura de dois ácidos estruturalmente semelhantes: ácido aristolóquico I e ácido aristolóquico II. As espécies de plantas que contém ácido aristolóquico são utilizadas essencialmente na medicina tradicional chinesa. Este artigo pretende rever a relação entre o efeito tóxico do ácido aristolóquico e a ocorrência de nefropatia e cancro. A ingestão de ácido aristolóquico provoca nefrotoxicidade, genotoxicidade e carcinogenicidade. A nefropatia por ácido aristolóquico e a nefropatia endémica nos Balcãs são causadas pela intoxicação alimentar por ácido aristolóquico e estão associadas à ocorrência de carcinoma urotelial do trato urinário superior. O ácido aristolóquico foi classificado como carcinogénico do grupo I pela International Agency for Research on Cancer. O conhecimento da relação direta entre os efeitos tóxicos do consumo de ácido aristolóquico e de nefropatia por ácido aristolóquico e carcinoma urotelial do trato urinário superior deve ser considerada importante para a sua futura prevenção.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Aristolochic acid is a natural toxic compound, from the family of a perennial herb, Aristolochia. It belongs to the family of nitrophenanthrole carboxylic acids and is a mixture of two structurally similar acids: aristolochic acid I and aristolochic acid II. Plant species containing aristolochic acid were used primarily in traditional Chinese medicine. The aim of this article is to review the relationship between the toxic effect of aristolochic acid and the occurrence of nephropathy and cancer. Ingestion of aristolochic acid causes nephrotoxicity, genotoxicity and carcinogenicity. Aristolochic acid nephropathy and endemic nephropathy in the Balkans are derived from aristolochic acid food poisoning and are highly associated with the occurrence of urothelial carcinoma of the upper urinary tract. Aristolochic acid was classified as a group I carcinogen by the International Agency for Research on Cancer. The knowledge of the direct relationship between the toxic effects of aristolochic acid consumption and the occurrence of aristolochic acid nephropathy and urothelial carcinoma of the upper urinary tract should be considered important for its future prevention.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Ácido Aristolóquico]]></kwd>
<kwd lng="pt"><![CDATA[Ácido Aristolóquico e Cancro]]></kwd>
<kwd lng="pt"><![CDATA[Nefropatia por Ácido Aristolóquico]]></kwd>
<kwd lng="en"><![CDATA[acid]]></kwd>
<kwd lng="en"><![CDATA[Aristolochic Acid and Cancer]]></kwd>
<kwd lng="en"><![CDATA[Aristolochic Acid Nephropathy]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bunel]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Souard]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Antoine]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
<name>
<surname><![CDATA[Stévigny]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Nortier]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nephrotoxicity of Natural Products: Aristolochic Acid and Fungal Toxins.]]></article-title>
<source><![CDATA[Compr Toxicol]]></source>
<year>2018</year>
<edition>Third Ed</edition>
</nlm-citation>
</ref>
<ref id="B2">
<label>2.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Han]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Xian]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Liang]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Systematic overview of aristolochic acids: Nephrotoxicity, carcinogenicity, and underlying mechanisms.]]></article-title>
<source><![CDATA[Front Pharmacol]]></source>
<year>2019</year>
<volume>10</volume>
</nlm-citation>
</ref>
<ref id="B3">
<label>3.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ji]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Feng]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Shi]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lack of correlation between aristolochic acid exposure and hepatocellular carcinoma.]]></article-title>
<source><![CDATA[Sci China Life Sci]]></source>
<year>2018</year>
<volume>61</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>727-8</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jelakovi&#263;]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Dika]]></surname>
<given-names><![CDATA[&#381;]]></given-names>
</name>
<name>
<surname><![CDATA[Arlt]]></surname>
<given-names><![CDATA[VM]]></given-names>
</name>
<name>
<surname><![CDATA[Stiborova]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pavlovi&#263;]]></surname>
<given-names><![CDATA[NM]]></given-names>
</name>
<name>
<surname><![CDATA[Nikoli&#263;]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid.]]></article-title>
<source><![CDATA[Semin Nephrol]]></source>
<year>2019</year>
<volume>39</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>284-96</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[HM]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[XH]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[ZH]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[GC]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[GC]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[LR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Recognition of the toxicity of aristolochic acid]]></article-title>
<source><![CDATA[J Clin Pharm Ther]]></source>
<year>2019</year>
<volume>44</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>157-62</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ma]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Qin]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Shen]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Bi]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aristolochic acid I is a substrate of BCRP but not P-glycoprotein or MRP2]]></article-title>
<source><![CDATA[J Ethnopharmacol]]></source>
<year>2015</year>
<volume>172</volume>
<page-range>430-5</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[CK]]></given-names>
</name>
<name>
<surname><![CDATA[Tung]]></surname>
<given-names><![CDATA[KK]]></given-names>
</name>
<name>
<surname><![CDATA[Pavlovi&#263;]]></surname>
<given-names><![CDATA[NM]]></given-names>
</name>
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Remediation of aristolochic acid- contaminated soil by an effective advanced oxidation process.]]></article-title>
<source><![CDATA[Sci Total Environ]]></source>
<year>2020</year>
<page-range>720</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Shi]]></surname>
<given-names><![CDATA[GR]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[YF]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[RY]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[DQ.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aristolochic acid derivatives from the rhizome of Arisolochia championii.]]></article-title>
<source><![CDATA[Fitoterapia]]></source>
<year>2017</year>
<volume>118</volume>
<page-range>63-8</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jadot]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Declèves]]></surname>
<given-names><![CDATA[AE]]></given-names>
</name>
<name>
<surname><![CDATA[Nortier]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Caron]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[An integrated view of aristolochic acid nephropathy: Update of the literature]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2017</year>
<volume>18</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B10">
<label>10.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[CK]]></given-names>
</name>
<name>
<surname><![CDATA[Wong]]></surname>
<given-names><![CDATA[YL]]></given-names>
</name>
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[KKJ]]></given-names>
</name>
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[HW]]></given-names>
</name>
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cooking methods employing natural anti-oxidant food additives effectively reduced concentration of nephrotoxic and carcinogenic aristolochic acids in contaminated food grains]]></article-title>
<source><![CDATA[Food Chemistry]]></source>
<year>2018</year>
<volume>Vol. 264</volume>
<page-range>270-6</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Luciano]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
<name>
<surname><![CDATA[Perazella]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aristolochic Acid Nephropathy: Epidemiology, Clinical Presentation, and Treatment.]]></article-title>
<source><![CDATA[Drug Saf.]]></source>
<year>2015</year>
<volume>38</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>55-64</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stiborová]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Frei]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Arlt]]></surname>
<given-names><![CDATA[VM]]></given-names>
</name>
<name>
<surname><![CDATA[Schmeiser]]></surname>
<given-names><![CDATA[HH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy]]></article-title>
<source><![CDATA[Mutat Res - Rev Mutat Res.]]></source>
<year>2008</year>
<volume>658</volume>
<numero>1-2</numero>
<issue>1-2</issue>
<page-range>55-67</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ye]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Qian]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Xue]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aristolochic acid I aggravates renal injury by activating the C3a/C3aR complement system.]]></article-title>
<source><![CDATA[Toxicol Lett]]></source>
<year>2019</year>
<volume>312</volume>
<page-range>118-24</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Abdullah]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Diaz]]></surname>
<given-names><![CDATA[LN]]></given-names>
</name>
<name>
<surname><![CDATA[Wesseling]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rietjens]]></surname>
<given-names><![CDATA[IMCM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Risk assessment of plant food supplements and other herbal products containing aristolochic acids using the margin of exposure (MOE) approach]]></article-title>
<source><![CDATA[Food Addit Contam - Part A Chem Anal Control Expo Risk Assess]]></source>
<year>2017</year>
<volume>34</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>135-44</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bastek]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Zubel]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Stemmer]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Mangerich]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Beneke]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Dietrich]]></surname>
<given-names><![CDATA[DR.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparison of Aristolochic acid I derived DNA adduct levels in human renal toxicity models.]]></article-title>
<source><![CDATA[Toxicology]]></source>
<year>2019</year>
<volume>420</volume>
<page-range>29-38</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stiborová]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Frei]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Schmeiser]]></surname>
<given-names><![CDATA[HH.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid.]]></article-title>
<source><![CDATA[Kidney Int]]></source>
<year>2008</year>
<volume>73</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1209-11</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Süntar]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Yak&#305;nc&#305;]]></surname>
<given-names><![CDATA[ÖF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Potential risks of phytonutrients associated with high-dose or long-term use.]]></article-title>
<source><![CDATA[Phytonutrients Food From Tradit to Ration Usage.]]></source>
<year>2019</year>
<page-range>137-55</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rosenquist]]></surname>
<given-names><![CDATA[TA]]></given-names>
</name>
<name>
<surname><![CDATA[Grollman]]></surname>
<given-names><![CDATA[AP.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mutational signature of aristolochic acid: Clue to the recognition of a global disease]]></article-title>
<source><![CDATA[DNA Repair]]></source>
<year>2016</year>
<volume>44</volume>
<page-range>205-11</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[J bo]]></given-names>
</name>
<name>
<surname><![CDATA[Bai]]></surname>
<given-names><![CDATA[Z fang]]></given-names>
</name>
<name>
<surname><![CDATA[Xiao]]></surname>
<given-names><![CDATA[X he.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Letter to the Editor: Is Aristolochic Acid the Major Cause of Liver Cancer in China and Asia?]]></article-title>
<source><![CDATA[Hepatology]]></source>
<year>2020</year>
<volume>71</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1130</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Michl]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Ingrouille]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Simmonds]]></surname>
<given-names><![CDATA[MSJ]]></given-names>
</name>
<name>
<surname><![CDATA[Heinrich]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Naturally occurring aristolochic acid analogues and their toxicities.]]></article-title>
<source><![CDATA[Nat Prod Rep.]]></source>
<year>2014</year>
<volume>31</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>676-93</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Debelle]]></surname>
<given-names><![CDATA[FD]]></given-names>
</name>
<name>
<surname><![CDATA[Vanherweghem]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Nortier]]></surname>
<given-names><![CDATA[JL.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aristolochic acid nephropathy: A worldwide problem]]></article-title>
<source><![CDATA[Kidney Int]]></source>
<year>2008</year>
<volume>74</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>158-69</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ekar]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Kreft]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Common risks of adulterated and mislabeled herbal preparations.]]></article-title>
<source><![CDATA[Food Chem Toxicol]]></source>
<year>2019</year>
<volume>123</volume>
<page-range>288-97</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kharchoufa]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Merrouni]]></surname>
<given-names><![CDATA[IA]]></given-names>
</name>
<name>
<surname><![CDATA[Yamani]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Elachouri]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Profile on medicinal plants used by the people of North Eastern Morocco: Toxicity concerns.]]></article-title>
<source><![CDATA[Toxicon]]></source>
<year>2018</year>
<volume>154</volume>
<page-range>90-113</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Malik]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bissinger]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Calabrò]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Faggio]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Jilani]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Lang]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aristolochic acid induced suicidal erythrocyte death]]></article-title>
<source><![CDATA[Kidney Blood Press Res]]></source>
<year>2014</year>
<volume>39</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>408-19.</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cheng]]></surname>
<given-names><![CDATA[WC]]></given-names>
</name>
<name>
<surname><![CDATA[Ng]]></surname>
<given-names><![CDATA[CS]]></given-names>
</name>
<name>
<surname><![CDATA[Poon]]></surname>
<given-names><![CDATA[NL.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Herbal Medicines and Phytopharmaceuticals - Contaminations.]]></article-title>
<source><![CDATA[Encycl Forensic Sci]]></source>
<year>2013</year>
<edition>Second Ed</edition>
<page-range>280-8</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Riffault-Valois]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Wattez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Langrand]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Boucaud-Maitre]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Gaslonde]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Colas]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Health risk associated with the oral consumption of &#8220;Chiniy-tref&#8221;, a traditional medicinal preparation used in Martinique (French West Indies): Qualitative and quantitative analyses of aristolochic acids contained therein.]]></article-title>
<source><![CDATA[Toxicon]]></source>
<year>2019</year>
<volume>172</volume>
<page-range>53-60</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ng]]></surname>
<given-names><![CDATA[AWT]]></given-names>
</name>
<name>
<surname><![CDATA[Poon]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[MN]]></given-names>
</name>
<name>
<surname><![CDATA[Lim]]></surname>
<given-names><![CDATA[JQ]]></given-names>
</name>
<name>
<surname><![CDATA[Boot]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia]]></article-title>
<source><![CDATA[Sci Transl Med]]></source>
<year>2017</year>
<volume>9</volume>
<numero>412</numero>
<issue>412</issue>
</nlm-citation>
</ref>
<ref id="B28">
<label>28.</label><nlm-citation citation-type="">
<collab>Food E</collab>
<collab>Authority S</collab>
<source><![CDATA[Compendium of botanicals reported to contain naturally occuring substances of possible concern for human health when used in food and.]]></source>
<year>2012</year>
<volume>10</volume>
<numero>5</numero>
<issue>5</issue>
</nlm-citation>
</ref>
<ref id="B29">
<label>29.</label><nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[notification_draft_2017_276_I_PT-]]></article-title>
<source><![CDATA[Ministerio-da-Saude-UE]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B30">
<label>30.</label><nlm-citation citation-type="journal">
<collab>INFARMED</collab>
<article-title xml:lang=""><![CDATA[O que acontece às notificações de RAM quando chegam ao INFARMED?]]></article-title>
<source><![CDATA[Bol Farm]]></source>
<year>2006</year>
</nlm-citation>
</ref>
<ref id="B31">
<label>31.</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vanherweghem]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[and Mushroom Nephrotoxicity.]]></source>
<year>1993</year>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
