<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2183-6914</journal-id>
<journal-title><![CDATA[Revista Onconews]]></journal-title>
<abbrev-journal-title><![CDATA[Revista Onconews]]></abbrev-journal-title>
<issn>2183-6914</issn>
<publisher>
<publisher-name><![CDATA[Associação de Enfermagem Oncológica Portuguesa (AEOP)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2183-69142021000100016</article-id>
<article-id pub-id-type="doi">10.31877/on.2021.42.02</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Infusion pump flow rates in central venous catheters: Thrombus reflux and aspiration clot.]]></article-title>
<article-title xml:lang="pt"><![CDATA[Perfusão através de infusor em cateteres venosos centrais: Refluxo e aspiração de trombos.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martinez]]></surname>
<given-names><![CDATA[Jose Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Capela]]></surname>
<given-names><![CDATA[Rita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Portuguese Institute of Oncology Porto Infection Control Department ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Portuguese Institute of Oncology Hematology-Oncology Department ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<numero>42</numero>
<fpage>16</fpage>
<lpage>20</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2183-69142021000100016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2183-69142021000100016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2183-69142021000100016&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Aggressive infusion pump flow rates can lead to central venous catheter (CVC) occlusion resulting from thrombus reflux into the CVC lumen.  Methods:  A single-center prospective comparative study was performed, including all consecutive cases of occlusion events in hematology oncology patients using a CVC (Hickman® nº7) since August 2018 to September 2019 (Phase 1), and October 2019 to September 2020 (Phase 2) at the Onco-Hematology Department of the Portuguese Institute of Oncology (Porto). Two phases were described: Phase 1: Observational period using a platinum-based regime (DHAP) undergoing continuous infusion pump rate &#8805; 200 mL/hr. Phase 2: Intervention period using a platinum-based regime (DHAP) undergoing continuous infusion pump rate &#8804; 200 mL/hr.  Results:  Overall, 39 DHAP regimens were reported with a total number of 43 occlusions identified in the study period (phase 1, n=28 vs phase 2, n=15). Occlusion risk associated with the infusion pump rates between phases was higher in phase 1 (phase 1, n=11 vs phase 2, n=3, RR 3.313 [1.010 to 13.863], &#8804;0.05). When aspiration clot (n=5) was identified, CVC always was removed. No aspiration clot was observed in phase 2.  Conclusion:  Aggressive infusion pump flow rates can increase occlusion risk resulting from thrombus reflux into the CVC lumen and aspiration clot.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo As taxas de perfusão contínuas elevadas podem levar a oclusão do cateter venoso central (CVC) através do refluxo e aspiração de trombos.  Metodologia:  Foi efetuado um estudo comparativo prospetivo, unicêntrico, incluindo todos os casos consecutivos de eventos obstrutivos em doentes hemato-oncológicos que usavam CVC (Hickman® nº7) desde agosto de 2018 a setembro de 2019 (Fase 1) e de outubro de 2019 a setembro de 2020 (Fase 2) no departamento de Onco-Hematologia do Instituto Português de Oncologia do Porto. Descrição das duas fases: Fase 1: Período observacional usando um esquema de QT à base de cisplatino (DHAP), com taxas de perfusão contínua &#8805; 200 mL/hr. Fase 2: Período de intervenção usando o esquema de QT à base de cisplatino (DHAP), com taxas de perfusão contínua &#8804; 200 mL/hr.  Resultados:  Ao longo do estudo foram realizados 39 esquemas de QT (DHAP), tendo-se identificado 43 oclusões de CVC (fase 1, n=28 vs fase 2, n=15). O risco de oclusão associado a altos débitos foi maior na primeira fase (fase 1, n=11 vs fase 2, n=3, RR 3.313 [1.010 to 13.863], &#8804;0.05). Quando foi identificada a aspiração de um trombo (n=5), o CVC foi sempre removido. Nenhum trombo por aspiração foi observado na fase 2.  Conclusão:  As taxas de perfusão contínuas elevadas podem aumentar o risco de oclusão do cateter venoso central (CVC) através do refluxo e aspiração de trombos.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Infusion pump]]></kwd>
<kwd lng="en"><![CDATA[Aggressive flushing]]></kwd>
<kwd lng="en"><![CDATA[Aspiration clot]]></kwd>
<kwd lng="en"><![CDATA[Occlusion.]]></kwd>
<kwd lng="pt"><![CDATA[Taxas de perfusão]]></kwd>
<kwd lng="pt"><![CDATA[Flush agressivo]]></kwd>
<kwd lng="pt"><![CDATA[Trombos de aspiração]]></kwd>
<kwd lng="pt"><![CDATA[Oclusão.]]></kwd>
</kwd-group>
</article-meta>
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