<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2183-8453</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Saúde Ocupacional online]]></journal-title>
<abbrev-journal-title><![CDATA[RPSO]]></abbrev-journal-title>
<issn>2183-8453</issn>
<publisher>
<publisher-name><![CDATA[Ajeogene Serviços Médicos Lda]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2183-84532025000100707</article-id>
<article-id pub-id-type="doi">10.31252.06.02.2025</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[QUIMIOPROFILAXIA DA TUBERCULOSE LATENTE E HEPATITE TÓXICA: UM CASO DE DOENÇA PROFISSIONAL (CASO CLÍNICO)]]></article-title>
<article-title xml:lang="en"><![CDATA[LATENT INFECTION TUBERCULOSIS PREVENTION TREATMENT AND TOXIC HEPATITIS: A WORK-RELATED DISEASE (CASE REPORT)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Miranda]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cunha]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soares]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade do Porto Faculdade de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade Nova de Lisboa Faculdade de Ciências Médicas NOVA Medical School]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade de Coimbra Faculdade de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade do Porto Faculdade de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidade Nova de Lisboa Faculdade de Ciências Médicas NOVA Medical School]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Universidade do Porto Faculdade de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>01</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>01</month>
<year>2025</year>
</pub-date>
<volume>19</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2183-84532025000100707&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2183-84532025000100707&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2183-84532025000100707&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  Introdução: A Tuberculose Latente é a infeção causada pelo Mycobacterium Tuberculosis que não resulta em doença ativa. O seu potencial de reativação em indivíduos saudáveis é baixo. A profilaxia pode ser por diversos esquemas farmacológicos, sendo que a maioria recorre à isoniazida, um fármaco com elevado potencial hepatotóxico.  Descrição do caso clínico: Trata-se de uma mulher com 56 anos de idade, profissional de saúde, tendo como único antecedente pessoal síndrome depressivo. Foi diagnosticada Tuberculose Latente em exame periódico de Medicina do Trabalho. Iniciou um esquema em monoterapia com isoniazida, desenvolvendo hepatite tóxica cerca de dois meses depois do início do tratamento com o antibacilar.  Discussão/Conclusão: Perante o diagnóstico de tuberculose latente, torna-se crucial a exclusão de doença ativa e a pesquisa de casos índice no local de trabalho. A caracterização da hepatite tóxica como Doença Profissional suscitou algumas dúvidas sobre inconsistências na fundamentação desta.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Latent infection Tuberculosis defines itself as the infection caused by Mycobacterium Tuberculosis that doesn&#8217;t provoke symptoms. It&#8217;s reactivation potential on healthy subjects is often low. There are various regimens established for the preventive treatment, most require the use of isoniazid, a drug with a high hepatotoxic potential.  Case description: Female, 56 years old, healthcare worker, with a background of depressive disorder. It was diagnosed with Latent Infection Tuberculosis. Started a regimen with isoniazid exclusively. About two months following the start of the treatment, she developed drug induced liver injury associated with the antitubercular agent.  Discussion/Conclusion: After the diagnosis of Latent infection tuberculosis, it is essential the exclusion of active disease tuberculosis and the investigation of active cases in the workplace. The acceptance of Toxic Hepatitis as a work-related disease raised some doubts regarding some inconsistencies in its justification.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Tuberculose Latente]]></kwd>
<kwd lng="pt"><![CDATA[Hepatite Tóxica]]></kwd>
<kwd lng="pt"><![CDATA[Profissional de saúde]]></kwd>
<kwd lng="pt"><![CDATA[Isoniazida]]></kwd>
<kwd lng="pt"><![CDATA[Saúde Ocupacional]]></kwd>
<kwd lng="pt"><![CDATA[Medicina do Trabalho]]></kwd>
<kwd lng="en"><![CDATA[Latent Infection Tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[Toxic Hepatitis]]></kwd>
<kwd lng="en"><![CDATA[Healthcare worker]]></kwd>
<kwd lng="en"><![CDATA[Isoniazid]]></kwd>
<kwd lng="en"><![CDATA[Occupational Health]]></kwd>
<kwd lng="en"><![CDATA[Occupational Medicine]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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