<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2184-0628</journal-id>
<journal-title><![CDATA[Gazeta Médica]]></journal-title>
<abbrev-journal-title><![CDATA[Gaz Med]]></abbrev-journal-title>
<issn>2184-0628</issn>
<publisher>
<publisher-name><![CDATA[Círculo Médico]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2184-06282020000300294</article-id>
<article-id pub-id-type="doi">10.29315/gm.v7i3.375</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Epistaxis e Hemorragia Digestiva Recorrente: Manifestação da Síndrome Osler-Weber-Rendu]]></article-title>
<article-title xml:lang="en"><![CDATA[Epistaxis and Gastrointestinal Bleeding: Manifestations of Osler-Weber-Rendu Syndrome]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rosete]]></surname>
<given-names><![CDATA[Marisa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gaudêncio]]></surname>
<given-names><![CDATA[Margarida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Magalhães]]></surname>
<given-names><![CDATA[Susana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[Fernando Ferraz e]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[Amélia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Distrital da Figueira da Foz Serviço de Medicina ]]></institution>
<addr-line><![CDATA[Figueira da Foz ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>09</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>09</month>
<year>2020</year>
</pub-date>
<volume>7</volume>
<numero>3</numero>
<fpage>294</fpage>
<lpage>299</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2184-06282020000300294&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2184-06282020000300294&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2184-06282020000300294&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A telangiectasia hemorrágica hereditária ou síndrome Osler-Weber-Rendu é uma doença vascular hereditária autossómica dominante, que se apresenta, geralmente, com telangiectasias mucocutâneas, epistaxe, hemorragia gastrointestinal, anemia ferripriva e malformações arteriovenosas. Os autores apresentam o caso clínico de um doente, género masculino, 78 anos, com insuficiência cardíaca descompensada, anemia ferripriva com necessidade transfusional e múltiplas telangiectasias. Nos antecedentes, destacava-se uma história de epistaxes espontâneas e recorrentes desde a juventude e episódio de hemorragia digestiva recente. Durante o internamento, apresentou epistaxe e hematoquézias, complicados com choque hipovolémico. Foi admitido o diagnóstico de síndrome de Osler-Weber-Rendu, tendo iniciado hormonoterapia. O internamento prolongou-se por complicações hemorrágicas e infeciosas, tendo o doente falecido ao 30º dia em edema agudo do pulmão. O caso apresentado corresponde a síndrome de Osler-Weber-Rendu, com critérios clínicos, apresentando uma evolução desfavorável.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Hereditary hemorrhagic telangiectasia, also called Osler-Weber-Rendu syndrome is an autosomal dominant vascular disorder with a variety of clinical manifestations. Among the most common are epistaxis, gastrointestinal bleeding, iron deficiency anemia, mucocutaneous telangiectasia and arteriovenous malformations. The authors propose to present the clinical case of a patient, male, 78-year-old with decompensated heart failure, iron deficiency anemia requiring transfusion and multiple telangiectasia. History of spontaneous and recurrent epistaxis since youth and recent episode of gastrointestinal bleeding. During hospitalization, he presented an episode of severe epistaxis and hematochezias, complicated by hypovolemic shock. The diagnosis of Osler-Weber-Rendu syndrome was admitted and he started hormone therapy. Prolonged hospitalization due to hemorrhagic and infectious complications, the patient died on the 30th day of hospitalization in the context of acute lung edema. The case presented corresponds to hereditary hemorrhagic telangiectasia. However, its diagnosis was late, presenting na unfavorable evolution.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Epistaxe]]></kwd>
<kwd lng="pt"><![CDATA[Hemorragia Gastrointestinal]]></kwd>
<kwd lng="pt"><![CDATA[Telangiectasia Hemorrágica Hereditária]]></kwd>
<kwd lng="en"><![CDATA[Epistaxis]]></kwd>
<kwd lng="en"><![CDATA[Gastrointestinal Hemorrhage]]></kwd>
<kwd lng="en"><![CDATA[Telangiectasia, Hereditary Hemorrhagic]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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