<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2184-0628</journal-id>
<journal-title><![CDATA[Gazeta Médica]]></journal-title>
<abbrev-journal-title><![CDATA[Gaz Med]]></abbrev-journal-title>
<issn>2184-0628</issn>
<publisher>
<publisher-name><![CDATA[Círculo Médico]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2184-06282020000400341</article-id>
<article-id pub-id-type="doi">10.29315/gm.v7i4.379</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[O Ácido Acetilsalicílico na Prevenção do Carcinoma Colorretal: Uma Revisão Baseada na Evidência]]></article-title>
<article-title xml:lang="en"><![CDATA[Acetylsalicylic Acid in the Prevention of Colorectal Cancer: An Evidence-Based Review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[Ana João]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,ACeS Cávado I USF Bracara Augusta ]]></institution>
<addr-line><![CDATA[Braga ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>7</volume>
<numero>4</numero>
<fpage>341</fpage>
<lpage>347</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2184-06282020000400341&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2184-06282020000400341&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2184-06282020000400341&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução:  O carcinoma colorretal é uma das principais causas de morbimortalidade por cancro no nosso país. Tem surgido evidência de que o ácido acetilsalicílico tem uma ação quimiopreventiva do carcinoma colorretal. Assim, este estudo tem como objetivo rever a evidência sobre o efeito do ácido acetilsalicílico na incidência e mortalidade do carcinoma colorretal.  Métodos:  Pesquisa de revisões sistemáticas, meta-ana&#769;lises, ensaios clínicos aleatorizados, estudos de coorte e normas de orientação clínica publicados entre 01/06/2010 a 01/06/2020, em base de dados de medicina baseada na evidência, com os termos MeSH &#8220;Aspirin&#8221; &#8220;Primary prevention&#8221; e &#8220;Colorectal neoplasms&#8221;. Para estratificar o ni&#769;vel de evidência dos estudos e a atribuição da força de recomendação, foi utilizada a escala Strength of Recommendation Taxonomy (SORT) da American Family Physician.  Resultados:  Selecionaram-se cinco de 57 artigos: uma meta-análise, duas revisões sistemáticas, um estudo de coorte e uma norma de orientação clínica. De uma forma geral, os estudos mostraram que o uso diário de no mínimo 75 mg de ácido acetilsalicílico durante cinco ou mais anos reduzia a incidência e a mortalidade de carcinoma colorretal. Contudo, deve ser usado com cautela pois associa-se a um aumento do risco hemorrágico.  Conclusão:  O uso de ácido acetilsalicílico poderá ser efetivo na redução da incidência e mortalidade de carcinoma colorretal em adultos com risco médio para carcinoma colorretal, atribuindo-se uma força de recomendação B (SORT B). Futuros estudos são necessários para determinar a dose e duração mínima do uso de ácido acetilsalicílico que confira um benefício oncológico acompanhada de um risco hemorrágico mínimo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  The colorectal cancer is one of the main causes of cancer morbimortality in our country. There has been evidence that acetylsalicylic acid has a chemopreventive effect on colorectal cancer. The aim of this study is to review the evidence of acetylsalicylic acid effect on the incidence and mortality of colorectal cancer.  Methods:  A research of systematic reviews, meta-analyzes, randomized clinical trials, cohort studies and clinical guidelines published between 01/06/2010 and 01/06/2020 was done in evidence-based medicine database, with the MeSH terms &#8220;Aspirin&#8221; &#8220;Primary prevention&#8221; and &#8220;Colorectal neoplasms&#8221;. The Strength of Recommendation Taxonomy (SORT) scale of the American Family Physician was used to stratify the studies levels and define their recommendation strength.  Results:  It were selected five of 57 articles: a meta-analysis, two systematic reviews, a cohort study, and a clinical guideline. In general, studies have shown that daily doses of 75 mg or more of acetylsalicylic acid for five years or more reduced the colorectal cancer incidence and mortality. However, acetylsalicylic acid should be used with caution due to its increased bleeding risk.  Conclusion:  The use of acetylsalicylic acid may be effective in reducing colorectal cancer incidence and mortality in adults with medium risk for colorectal cancer with their recommendation strength B (SORT B). Further studies are necessary in order to define the lowest dose and duration of acetylsalicylic acid use that provides an oncological benefit with a lowest bleeding risk.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Ácido Acetilsalicílico/uso terapêutico]]></kwd>
<kwd lng="pt"><![CDATA[Anti-Inflamatórios não Esteroides/uso terapêutico]]></kwd>
<kwd lng="pt"><![CDATA[Neoplasias Colorretais/prevenção e controlo]]></kwd>
<kwd lng="en"><![CDATA[Anti-Inflammatory Agents, Non-Steroidal/therapeutic use]]></kwd>
<kwd lng="en"><![CDATA[Aspirin/therapeutic use]]></kwd>
<kwd lng="en"><![CDATA[Colorectal Neoplasms/prevention &amp; control]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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