<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2184-0628</journal-id>
<journal-title><![CDATA[Gazeta Médica]]></journal-title>
<abbrev-journal-title><![CDATA[Gaz Med]]></abbrev-journal-title>
<issn>2184-0628</issn>
<publisher>
<publisher-name><![CDATA[Círculo Médico]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2184-06282020000400392</article-id>
<article-id pub-id-type="doi">10.29315/gm.v7i4.378</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Hepatite Colestática Aguda Secundária a Amoxicilina/Ácido Clavulânico]]></article-title>
<article-title xml:lang="en"><![CDATA[Acute Cholestatic Hepatitis Caused by Amoxicilin/Clavunate]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rosete]]></surname>
<given-names><![CDATA[Marisa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Antunes]]></surname>
<given-names><![CDATA[Joana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gaudêncio]]></surname>
<given-names><![CDATA[Margarida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[Fernando Ferraz e]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[Amélia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Distrital da Figueira da Foz Serviço de Medicina ]]></institution>
<addr-line><![CDATA[Figueira da Foz ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>7</volume>
<numero>4</numero>
<fpage>392</fpage>
<lpage>395</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2184-06282020000400392&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2184-06282020000400392&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2184-06282020000400392&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A amoxicilina/ácido clavulânico é um antibiótico muito usado na prática clínica para diversas infeções. Está associada a uma pequena percentagem de casos de lesão hepática secundária a fármacos, sendo a hepatite e colestase complicações raras. Os autores apresentam o caso clínico de doente, de 65 anos, género masculino, admitido no serviço de urgência por dor abdominal, colúria, acolia fecal, prurido generalizado e anorexia com 4 dias de evolução. Nos 21 dias prévios, fez curso de 7 dias de antibioterapia com amoxicilina/ácido clavulânico por amigdalite, negando uso de outros fármacos. Dos exames complementares efetuados, destaca-se hiperbilirrubinémia direta, elevação das transaminases, fosfatase alcalina e gama-GT. As serologias víricas, bacterianas e de auto-imunidade foram negativas. Realizou biópsia hepática que mostrou inflamação hepatocelular, colestase e lesão dos ductos biliares. Conclui-se tratar-se de hepatite colestática secundária a amoxicilina/ácido clavulânico. Foi submetido a terapêutica de suporte, com colestiramina e ácido ursodesoxicólico para controlo de prurido, não realizando nenhum tratamento específico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract A 65-year-old man was admitted to the emergency room, with a history of abdominal pain, choluria, fecal acholia, generalized pruritus and anorexia for four days. He indicated that it had been approximately 21 days since he had used amoxicillin/calvulanate for 7 days for tonsillitis and denied using any other medications. Laboratory data showed direct hyperbilirubinemia and elevated liver enzymes. Diagnostic investigation began with serological tests for virus, bacteria and auto-immunity which were negative. A liver biopsy was performed, and the pathology showed hepatocellular inflammation, cholestasis, and bile duct damage. Conclusion: The patient was diagnosed with cholestatic hepatitis associated with amoxicillin/clavulanate. He did not receive any specific treatment, only cholestyramine and ursodeoxycholic acid for pruritus.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Colestase Intra-Hepática/etiologia]]></kwd>
<kwd lng="pt"><![CDATA[Combinação Amoxicilina e Clavulanato de Potássio/efeitos adversos]]></kwd>
<kwd lng="pt"><![CDATA[Doença Hepática Induzida por Medicamentos]]></kwd>
<kwd lng="en"><![CDATA[Amoxicillin-Potassium Clavulanate Combination/adverse effects]]></kwd>
<kwd lng="en"><![CDATA[Chemical and Drug Induced Liver Injury]]></kwd>
<kwd lng="en"><![CDATA[Cholestasis, Intrahepatic/etiology]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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