<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2184-0628</journal-id>
<journal-title><![CDATA[Gazeta Médica]]></journal-title>
<abbrev-journal-title><![CDATA[Gaz Med]]></abbrev-journal-title>
<issn>2184-0628</issn>
<publisher>
<publisher-name><![CDATA[Círculo Médico]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2184-06282021000400302</article-id>
<article-id pub-id-type="doi">10.29315/gm.v1i1.499</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Lúpus Eritematoso Cutâneo Subagudo Induzido por Amlodipina]]></article-title>
<article-title xml:lang="en"><![CDATA[Amlodipine-Induced Subacute Cutaneous Lupus Erythematosus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Longras]]></surname>
<given-names><![CDATA[Carla]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dias]]></surname>
<given-names><![CDATA[Pedro Costa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alves]]></surname>
<given-names><![CDATA[Fontes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[Joana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rocha]]></surname>
<given-names><![CDATA[Joana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidade Local de Saúde de Matosinhos Unidade de Saúde Familiar Lagoa ]]></institution>
<addr-line><![CDATA[Matosinhos ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Unidade Local de Saúde de Matosinhos Unidade de Saúde Familiar Caravela ]]></institution>
<addr-line><![CDATA[Matosinhos ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Unidade Local de Saúde de Matosinhos Unidade de Saúde Familiar Infesta ]]></institution>
<addr-line><![CDATA[Matosinhos ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Unidade Local de Saúde de Matosinhos Hospital Pedro Hispano Serviço de Anatomia Patológica]]></institution>
<addr-line><![CDATA[Matosinhos ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Unidade Local de Saúde de Matosinhos Hospital Pedro Hispano Serviço de Dermato-Venereologia]]></institution>
<addr-line><![CDATA[Matosinhos ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>8</volume>
<numero>4</numero>
<fpage>302</fpage>
<lpage>306</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2184-06282021000400302&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2184-06282021000400302&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2184-06282021000400302&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo O lúpus eritematoso cutâneo subagudo é uma variante de lúpus eritematoso cutâneo que se manifesta por lesões anulares ou psoriasiformes. Pode ser induzido por fármacos e tem, no geral, um bom prognóstico. Dados publicados sugerem que os bloqueadores dos canais de cálcio estão entre os vários medicamentos implicados no seu aparecimento. Homem de 76 anos com antecedentes de doença coronária, urticária crónica e depressão, medicado com amlodipina após cateterismo cardíaco. Três meses depois desenvolveu lesões maculopapulares e placas anulares rosadas, ligeiramente descamativas e pruriginosas, que atingiam predominantemente o tronco e, em menor extensão, os membros. Negava outros sintomas. Foi realizado estudo analítico, biópsia cutânea e exame micológico. A histologia cutânea revelou aspetos compatíveis com lúpus eritematoso subagudo. Os restantes exames foram normais. Observou-se melhoria do quadro após corticoterapia oral e suspensão de amlodipina. Com este caso pretende-se realçar a importância de estar alerta para toxidermias pouco frequentes que podem ser induzidas por fármacos de utilização corrente na prática clínica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Subacute cutaneous lupus erythematosus is a subtype of cutaneous lupus erythematosus characterized by annular or psoriasiform lesions. In general, it has a good prognosis. Some drugs may trig this skin disease, as such as the calcium channel blockers. A 76-year-old man with personal history of coronary heart disease, chronic urticaria and depression received amlodipine after cardiac catheterization. Three months later, he presented with a pink pruritic slightly scaly maculopapular skin eruption and annular plaques affecting mainly the trunk and the limbs to a lesser extent. No other symptom was reported. Extensive blood tests, skin biopsy and mycology exam were performed. The histological examination of the skin tissue was compatible with subacute lupus erythematosus. The remaining laboratory study was normal. Remarkable improvement was seen after systemic steroid therapy and withdrawal of amlodipine. This case report emphasizes that is important to be on the lookout for uncommon skin reaction triggered by drugs widely used in clinical practice.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Amlodipina]]></kwd>
<kwd lng="pt"><![CDATA[Lúpus Eritematoso Cutâneo]]></kwd>
<kwd lng="en"><![CDATA[Amlodipine]]></kwd>
<kwd lng="en"><![CDATA[Lupus Erythematosus, Cutaneous]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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