<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2184-0628</journal-id>
<journal-title><![CDATA[Gazeta Médica]]></journal-title>
<abbrev-journal-title><![CDATA[Gaz Med]]></abbrev-journal-title>
<issn>2184-0628</issn>
<publisher>
<publisher-name><![CDATA[Círculo Médico]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2184-06282021000400307</article-id>
<article-id pub-id-type="doi">10.29315/gm.v1i1.458</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Reação de Jarisch-Herxheimer como Causa Incomum de Dor Abdominal Após o Tratamento de Sífilis: Relato de Caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Jarisch-Herxheimer Reaction as an Uncommon Cause of Abdominal Pain After Syphilis Treatment: Case Report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[Vânia de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[Filipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Neto]]></surname>
<given-names><![CDATA[Cátia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Celina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tarrio]]></surname>
<given-names><![CDATA[Maria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,ACeS Alto Ave USF S. Nicolau ]]></institution>
<addr-line><![CDATA[Guimarães ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>8</volume>
<numero>4</numero>
<fpage>307</fpage>
<lpage>310</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2184-06282021000400307&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2184-06282021000400307&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2184-06282021000400307&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A sífilis é uma infeção sistémica com manifestações variáveis consoante o seu estádio clínico. Conhecida como &#8220;a grande imitadora&#8221;, a sua abordagem é ainda mais desafiante quando ocorre a reação de Jarisch-Herxheimer (JH). Esta trata-se de uma reação febril aguda autolimitada que pode ocorrer nas 24 horas após tratamento de uma infeção por espiroquetas. Reporta-se o caso de um homem de 33 anos com sífilis secundária que desenvolve uma reação de JH após três horas da administração de benzilpenicilina benzatínica 2,4 milhões de unidades internacionais, apresentando febre, agravamento do exantema inicial, dor abdominal e disfunção hepatocelular, estas últimas manifestações descritas como incomuns. Os autores discutem a fisiopatologia desta reação, as suas manifestações clínicas e recomendações de abordagem à luz da evidência atual.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Syphilis is a systemic infection with variable manifestations depending on its clinical stage. Known as "the great imitator", its management is even more defying when the Jarisch-Herxheimer reaction occurs, which is a self-limited acute febrile reaction that occurs within 24 hours after treatment for a spirochete infection. The authors describe the case of a 33-year-old man with a secondary syphilis who, three hours after the administration of benzathine benzylpenicillin 2.4 million international units, presents with fever, worsening of the initial cutaneous manifestations, abdominal pain and hepatocellular dysfunction, these last two described as unusual manifestations of this reaction. The authors discuss the pathophysiology of the Jarisch-Herxheimer reaction, its clinical manifestations and management recommendations according to the current evidence.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Dor Abdominal]]></kwd>
<kwd lng="pt"><![CDATA[Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos]]></kwd>
<kwd lng="pt"><![CDATA[Febre/induzida quimicamente]]></kwd>
<kwd lng="pt"><![CDATA[Sífilis/tratamento farmacológico]]></kwd>
<kwd lng="en"><![CDATA[Abdominal Pain]]></kwd>
<kwd lng="en"><![CDATA[Drug-Related Side Effects and Adverse Reactions]]></kwd>
<kwd lng="en"><![CDATA[Fever/chemically induced]]></kwd>
<kwd lng="en"><![CDATA[Syphilis/drug therapy]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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