<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2184-0628</journal-id>
<journal-title><![CDATA[Gazeta Médica]]></journal-title>
<abbrev-journal-title><![CDATA[Gaz Med]]></abbrev-journal-title>
<issn>2184-0628</issn>
<publisher>
<publisher-name><![CDATA[Círculo Médico]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2184-06282023000100042</article-id>
<article-id pub-id-type="doi">10.29315/gm.v1i1.679</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Pormenores que Contam: Descrição de um Caso de Anemia Perniciosa]]></article-title>
<article-title xml:lang="en"><![CDATA[Details that Count: Description of a Case of Pernicious Anemia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[Bárbara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nogueira]]></surname>
<given-names><![CDATA[Rita Cancela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Brigas]]></surname>
<given-names><![CDATA[Diana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marques]]></surname>
<given-names><![CDATA[Ana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidade de Saúde de Água de Pau  ]]></institution>
<addr-line><![CDATA[Água de Pau ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Unidade de Saúde Familiar Fiães  ]]></institution>
<addr-line><![CDATA[Santa Maria da Feira ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<volume>10</volume>
<numero>1</numero>
<fpage>42</fpage>
<lpage>45</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2184-06282023000100042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2184-06282023000100042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2184-06282023000100042&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A anemia perniciosa é uma doença autoimune que cursa com défice de absorção de vitamina B 12. Para além da anemia macrocítica, pode causar alterações neurológicas e gastrointestinais. Homem, 76 anos, com quadro de esquecimentos frequentes, astenia, tonturas, dispneia e sensação de mal-estar. Realizou estudo analítico que demonstrou anemia macrocítica, com hemoglobina de 7,4 g/dL. Foi referenciado ao serviço de urgência, onde repetiu estudo que revelou défice de vitamina B 12, com anticorpo anti-fator intrínseco e anticorpo anti-células parietais do estômago positivos, sendo confirmado o diagnóstico de anemia perniciosa. Realizou duas unidades de glóbulos vermelhos e teve alta medicado com vitamina B 12 intramuscular. Após o diagnóstico foram revistos os antecedentes do utente e verificaram-se queixas de alteração da memória e aumento do volume globular médio desde 2015. Pelos sintomas insidiosos, esta patologia pode ser subdiagnosticada. Este caso pretende relembrar a importância de valorizar alterações clínicas e analíticas, mesmo que subtis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ Abstract Pernicious anemia is an autoimmune disease associated with vitamin B12 absorption deficit. In addition of macrocytic anemia, it can cause neurological and gastrointestinal changes. Male, 76 years old, with memory loss, asthenia, dizziness, dyspnea and feeling of malaise. The analytical study carried out showed macrocytic anemia, with hemoglobin of 7.4 g/dL. The patient was referred to the emergency department, where the analytic study revealed vitamin B12 deficit, positive anti-intrinsic factor antibodies and positive anti-parietal cell antibody, confirming the diagnosis of pernicious anemia. There, he was given two units of red blood cells and he had hospital discharge medicated with intramuscular vitamin B12. After the diagnosis, the patient&#8217;s clinical history was reviewed and showed that there were complaints about memory alterations and increase of the mean of globular volume since 2015. Due to the insidious symptoms, this pathology can be underdiagnosed. This case intends to stress the importance of valuing clinical and analytical alterations, even if subtle.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Anemia Perniciosa]]></kwd>
<kwd lng="pt"><![CDATA[Células Parietais Gástricas]]></kwd>
<kwd lng="pt"><![CDATA[Deficiência de Vitamina B 12]]></kwd>
<kwd lng="pt"><![CDATA[Fator Intrínseco]]></kwd>
<kwd lng="en"><![CDATA[Anemia, Pernicious]]></kwd>
<kwd lng="en"><![CDATA[Intrinsic Factor]]></kwd>
<kwd lng="en"><![CDATA[Parietal Cells, Gastric]]></kwd>
<kwd lng="en"><![CDATA[Vitamin B 12 Deficiency]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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