<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2184-0628</journal-id>
<journal-title><![CDATA[Gazeta Médica]]></journal-title>
<abbrev-journal-title><![CDATA[Gaz Med]]></abbrev-journal-title>
<issn>2184-0628</issn>
<publisher>
<publisher-name><![CDATA[Círculo Médico]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2184-06282023000300225</article-id>
<article-id pub-id-type="doi">10.29315/gm.v1i1.624</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Reed's Syndrome: A Rare Systemic Genodermatosis]]></article-title>
<article-title xml:lang="pt"><![CDATA[Reed&#8217;s Syndrome: Uma Genodermatose Sistémica Rara]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Braga]]></surname>
<given-names><![CDATA[Madalena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Leonor Ferreira da]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[Nuno Mendanha]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[Gustavo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Magalhães]]></surname>
<given-names><![CDATA[Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,ACeS Porto Oriental USF Arca D&#8217;Água ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>09</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>09</month>
<year>2023</year>
</pub-date>
<volume>10</volume>
<numero>3</numero>
<fpage>225</fpage>
<lpage>228</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2184-06282023000300225&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2184-06282023000300225&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2184-06282023000300225&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Reed's syndrome is an autosomal dominant rare genodermatosis, characterized by the presence of multiple cutaneous and uterine leiomyomatosis. This syndrome can be associated with renal cell carcinoma and leiomyosarcoma. A 55-year-old woman presented to routine consultation. Physical examination was notorious for the presence of multiple asymmetrical, irregular, skin-colored, with a smooth surface papules and nodules on her chest and left arm. They had been present for about two decades. The patient's past medical history was significant for myomectomy and hysterectomy. A cutaneous papule&#8217;s biopsy revealed a leiomyoma. Clinical and histological findings combined with surgical history suggested Reed's syndrome, which was later confirmed by genetic tests. Her family was referred for genetic counseling. Systematic review of skin lesions is essential, as they can be the diagnostic clue for systemic diseases.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A síndrome de Reed é uma genodermatose rara, autossómica dominante, caracterizada pela presença de múltiplos leiomiomas cutâneos e uterinos, podendo estar associada a carcinoma de células renais e leiomiossarcoma. Uma mulher de 55 anos foi observada em consulta de rotina. À observação, apresentava múltiplas pápulas e nódulos no tórax e braço esquerdo, assimétricos, irregulares, cor de pele e de superfície lisa, que referia estarem presentes há cerca de duas décadas. A doente tinha antecedentes de miomectomia e histerectomia. A biópsia de uma pápula torácica revelou um leiomioma. De acordo com os achados clínicos e histológicos e antecedentes cirúrgicos, foi colocada a hipótese diagnóstica de síndrome de Reed, confirmada posteriormente por teste genético. A família da utente foi também referenciada para aconselhamento genético. O exame sistemático de lesões cutâneas é de grande relevância, pois estas podem ser elementos clínicos orientadores do diagnóstico de doenças sistémicas.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Leiomiomatose]]></kwd>
<kwd lng="pt"><![CDATA[Neoplasias da Pele]]></kwd>
<kwd lng="pt"><![CDATA[Neoplasias do Rim]]></kwd>
<kwd lng="pt"><![CDATA[Síndromes Neoplásicas Hereditárias]]></kwd>
<kwd lng="en"><![CDATA[Kidney Neoplasms]]></kwd>
<kwd lng="en"><![CDATA[Leiomyomatosis]]></kwd>
<kwd lng="en"><![CDATA[Neoplastic Syndromes, Hereditary]]></kwd>
<kwd lng="en"><![CDATA[Skin Neoplasms]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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