<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2184-0628</journal-id>
<journal-title><![CDATA[Gazeta Médica]]></journal-title>
<abbrev-journal-title><![CDATA[Gaz Med]]></abbrev-journal-title>
<issn>2184-0628</issn>
<publisher>
<publisher-name><![CDATA[Círculo Médico]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2184-06282024000100028</article-id>
<article-id pub-id-type="doi">10.29315/gm.v1i1.788</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Hyperbaric Oxygen Therapy as a Complementary Treatment for Osteoradionecrosis of the Mandible: Useless or Useful? - A Literature Review]]></article-title>
<article-title xml:lang="pt"><![CDATA[Oxigenoterapia Hiperbárica como Terapêutica Complementar para a Osteorradionecrose da Mandíbula: Fútil ou Útil? - Uma Revisão da Literatura]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[Diogo Alpuim]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3 "/>
<xref ref-type="aff" rid="Af4"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[Joana Arana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Amaro]]></surname>
<given-names><![CDATA[Carla D&#8217;Espiney]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,CUF Oncologia Haematology and Oncology Department ]]></institution>
<addr-line><![CDATA[Lisbon ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Cascais Dr. José de Almeida Medical Oncology Department, ]]></institution>
<addr-line><![CDATA[Cascais ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro Hiperbárico de Cascais (CHC),  ]]></institution>
<addr-line><![CDATA[Cascais ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Faculdade de Ciências Médicas da Universidade NOVA de Lisboa NOVA Medical School ]]></institution>
<addr-line><![CDATA[Lisbon ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,University of Lisbon Faculty of Medicine ]]></institution>
<addr-line><![CDATA[Lisbon ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,AIM Cancer Center  ]]></institution>
<addr-line><![CDATA[Esposende ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Unidade Local de Saúde da Guarda Pulmonology Department ]]></institution>
<addr-line><![CDATA[Guarda ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af8">
<institution><![CDATA[,CUF Descobertas Otorhinolaryngology Department ]]></institution>
<addr-line><![CDATA[Lisbon ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af9">
<institution><![CDATA[,Portuguese Navy Centro de Medicina Subaquática e Hiperbárica (CMSH) ]]></institution>
<addr-line><![CDATA[Lisbon ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>03</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>03</month>
<year>2024</year>
</pub-date>
<volume>11</volume>
<numero>1</numero>
<fpage>28</fpage>
<lpage>38</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2184-06282024000100028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2184-06282024000100028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2184-06282024000100028&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Radiotherapy (RT) is a key component of managing head and neck cancer patients. However, despite the emergence and improvement of new RT techniques, late complications may occur, such as osteoradionecrosis of the mandible (ORNM). The diagnosis is based on clinical/radiological criteria. In the established ORNM, the chronic process does not solve spontaneously, and optimal management still needs to be established. Over the last decades, a broad therapeutic spectrum has been considered, including hyperbaric oxygen therapy (HBOT). Although, the clinical impact of HBOT varies according to the literature, which is why there is a current controversy regarding its benefits. Further prospective and randomised studies are needed to validate its effectiveness in the 'real-world' clinical practice. This article aims to synthesise the existing data, analyse previous studies´ results, identify gaps in knowledge, and discuss ORNM&#8217; management, including a proposal for an algorithm, with a particular focus on HBOT.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A radioterapia (RT) é uma componente fundamental do tratamento multimodal dos doentes com cancro da cabeça e pescoço. Contudo, apesar do surgimento e aperfeiçoamento das técnicas de RT, podem ocorrer complicações tardias, como a osteorradionecrose da mandíbula (ORNM). O seu diagnóstico é baseado em critérios clínicos/radiológicos. Na ORNM estabelecida, o processo crónico não resolve espontaneamente e, até à data, não foi estabelecida uma abordagem terapêutica ótima. Nas últimas décadas foram considerados diversos tipos de tratamento, incluído a oxigenoterapia hiperbárica (HBOT). Contudo, o impacto clínico da HBOT varia de acordo com a literatura, o que gera controvérsia em relação aos seus benefícios. Estudos prospetivos e aleatorizados adicionais são essenciais para validar a eficácia deste tratamento na prática clínica. O objetivo deste artigo é sintetizar os dados existentes, analisar os resultados de estudos prévios, identificar lacunas no conhecimento e discutir a abordagem da ORNM, incluindo uma proposta de algoritmo terapêutico com especial enfoque na HBOT.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Doenças da Mandíbula/tratamento]]></kwd>
<kwd lng="pt"><![CDATA[Osteorradionecrose/tratamento]]></kwd>
<kwd lng="pt"><![CDATA[Oxigenoterapia Hiperbárica]]></kwd>
<kwd lng="en"><![CDATA[Hyperbaric Oxygenation]]></kwd>
<kwd lng="en"><![CDATA[Mandibular Diseases/therapy]]></kwd>
<kwd lng="en"><![CDATA[Osteoradionecrosis/therapy]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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