<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2341-4545</journal-id>
<journal-title><![CDATA[GE-Portuguese Journal of Gastroenterology]]></journal-title>
<abbrev-journal-title><![CDATA[GE Port J Gastroenterol]]></abbrev-journal-title>
<issn>2341-4545</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Gastrenterologia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2341-45452021000600398</article-id>
<article-id pub-id-type="doi">10.1159/000516008</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Is There an Optimal Age Threshold for Searching for Intestinal Metaplasia on Gastric Mucosa in Western Populations?]]></article-title>
<article-title xml:lang="pt"><![CDATA[Existirá um limite de idade ideal para identificação de metaplasia intestinal na mucosa gástrica em populações Ocidentais?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zullo]]></surname>
<given-names><![CDATA[Angelo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lahner]]></surname>
<given-names><![CDATA[Edith]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hassan]]></surname>
<given-names><![CDATA[Cesare]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Annibale]]></surname>
<given-names><![CDATA[Bruno]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Esposito]]></surname>
<given-names><![CDATA[Gianluca]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Nuovo Regina Margherita Hospital Gastroenterology and Digestive Endoscopy ]]></institution>
<addr-line><![CDATA[Rome ]]></addr-line>
<country>Italy</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Sapienza University of Rome Sant&#8217;Andrea Hospital Department of Medical-Surgical Sciences and Translational Medicine]]></institution>
<addr-line><![CDATA[Rome ]]></addr-line>
<country>Italy</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>28</volume>
<numero>6</numero>
<fpage>398</fpage>
<lpage>402</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2341-45452021000600398&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2341-45452021000600398&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2341-45452021000600398&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  Since screening programs for gastric cancer are not applicable in Western countries, identification and follow-up of gastric precancerous lesions, such as extensive intestinal metaplasia (IM), are worthwhile to increase the diagnosis of cancer at an early stage. We investigated whether an optimal age threshold to detect extensive IM in a European country exists.  Methods: This was a post hoc analysis of prospectively collected data in a nationwide study involving consecutive patients aged between 50 and 65 years who underwent an upper endoscopy with the standard 5 gastric biopsies. The presence of extensive (antral and gastric body) IM on gastric mucosa was considered.  Results: Data found that the prevalence of extensive IM was distinctly higher in patients aged 60-65 years, with a 2.28-fold increased probability compared to younger patients. None of the other considered factors (sex, BMI, smoking habit, first-degree family history, and symptoms) emerged as an independent predictor of extensive IM in the stomach.  Conclusion: When deciding for an occasional gastric cancer screening in Western populations, the choice of an age range of 60-65 years might be appropriate, allowing detection of a distinctly high prevalence of extensive IM deserving scheduled follow-up.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  Como os programas de rastreio de cancro gástrico não se aplicam em populações Ocidentais, a identificação e vigilância de lesões gástricas pré-mali gnas, como a metaplasia intestinal (MI) extensa, são valiosas ao aumentar o diagnóstico de cancro em estadios precoces. Neste estudo, investigamos se existe um limite de idade ideal para detetar metaplasia intestinal num país Europeu.  Métodos: Fizemos uma análise post-hoc de dados reunidos prospectivamente de um estudo de base nacional que incluiu doentes consecutivos com idade entre 50 e 65 anos que fizeram endoscopia digestiva alta com colheita protocolada de 5 biopsias gástricas. A presença de MI extensa (antro e corpo) foi avaliada.  Resultados: A prevalência de MI extensa foi significativamente superior nos doentes com 60-65 anos, com uma probabilidade 2.28 vezes aumentada quando comparado com doentes mais jovens. Nenhum dos outros potenciais fatores (sexo, indice massa corporal, hábitos tabágicos, história familiar 1º grau de cancro gástrico e sintomas) se revelou como um fator predictor independente de MI extensa gástrica.  Conclusão: Na decisão de rastreio ocasional de cancro gástrico em populações Ocidentais a escolha do intervalo de idade de 60-65 anos pode ser apropriada, permitindo a deteção de uma prevalência significativamente alta de MI extensa, justificando vigilância programada.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Intestinal metaplasia]]></kwd>
<kwd lng="en"><![CDATA[Gastric cancer]]></kwd>
<kwd lng="en"><![CDATA[Screening]]></kwd>
<kwd lng="en"><![CDATA[Endoscopy]]></kwd>
<kwd lng="en"><![CDATA[Age]]></kwd>
<kwd lng="pt"><![CDATA[Metaplasia intestinal]]></kwd>
<kwd lng="pt"><![CDATA[Cancro gástrico]]></kwd>
<kwd lng="pt"><![CDATA[Rastreio]]></kwd>
<kwd lng="pt"><![CDATA[Endoscopia]]></kwd>
<kwd lng="pt"><![CDATA[Idade]]></kwd>
</kwd-group>
</article-meta>
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