<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2341-4545</journal-id>
<journal-title><![CDATA[GE-Portuguese Journal of Gastroenterology]]></journal-title>
<abbrev-journal-title><![CDATA[GE Port J Gastroenterol]]></abbrev-journal-title>
<issn>2341-4545</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Gastrenterologia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2341-45452025000200042</article-id>
<article-id pub-id-type="doi">10.1159/000539093</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Hepatocellular Carcinoma with Vascular and Cardiac Involvement in a Young Patient with Non-Cirrhotic Hepatitis B: A Case Report]]></article-title>
<article-title xml:lang="pt"><![CDATA[Carcinoma hepatocelular com envolvimento vascular e cardíaco num jovem com hepatite B não cirrótica]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Botto]]></surname>
<given-names><![CDATA[Inês]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Serrazina]]></surname>
<given-names><![CDATA[Juliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Freitas]]></surname>
<given-names><![CDATA[Carlos Rodrigues]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carvalhana]]></surname>
<given-names><![CDATA[So&#64257;a]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nogueira-Costa]]></surname>
<given-names><![CDATA[Gonçalo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cortez-Pinto]]></surname>
<given-names><![CDATA[Helena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidade Local de Saúde de Santa Maria Serviço de Gastrenterologia e Hepatologia ]]></institution>
<addr-line><![CDATA[Lisbon ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Unidade Local de Saúde de Santa Maria Serviço de Oncologia ]]></institution>
<addr-line><![CDATA[Lisbon ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade de Lisboa Faculdade de Medicina ]]></institution>
<addr-line><![CDATA[Lisbon ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<volume>32</volume>
<numero>2</numero>
<fpage>42</fpage>
<lpage>46</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2341-45452025000200042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2341-45452025000200042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2341-45452025000200042&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Hepatocellular carcinoma (HCC) is a highly vascular malignancy with the potential for intravascular invasion. However, vascular extension into the cardiac chambers is extremely rare.  Case Presentation: We present a 25-year-old male patient in whom the investigation of a cardiac murmur led to the discovery of an intracardiac mass that proved to be advanced-stage HCC with vascular invasion of the right heart. The patient had a previously unknown non-cirrhotic chronic hepatitis B virus (HBV) infection. Despite antiviral therapy and systemic treatment for HCC, he eventually died about 1 month later due to disease progression.  Conclusion: This report highlights the importance of early HBV diagnosis and treatment for timely detection and management of HCC. Advanced-stage HCC, particularly with cardiac involvement, has an extremely poor prognosis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo Introdução: O carcinoma hepatocelular é uma neoplasia com elevado risco de invasão vascular, porém, a invasão cardíaca está raramente descrita.  Descrição do caso: Descreve-se um caso de um doente, do sexo masculino, de 25 anos, sem antecedentes de cirrose hepática, que se apresentou com queixas de cansaço, dispneia e perda ponderal. A investigação adicional mostrou um sopro cardíaco, resultante da invasão cardíaca direita por carcinoma hepatocelular e hepatite B crónica. Apesar da instituição da terapêutica dirigida ao carcinoma hepatocelular e terapêutica antiviral, veri&#64257;cou-se progressão da doença levando ao falecimento do doente um mês após o diagnóstico.  Conclusão: Este caso destaca a importância do diagnóstico e tratamento precoces da hepatite B crónica, potenciando a deteção atempada do carcinoma hepatocelular. O carcinoma hepatocelular em estadio avançado, nomeadamente com invasão cardíaca, está associado a mau prognóstico.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Hepatocellular carcinoma]]></kwd>
<kwd lng="en"><![CDATA[Hepatitis B virus]]></kwd>
<kwd lng="en"><![CDATA[Right atrial extension]]></kwd>
<kwd lng="pt"><![CDATA[Carcinoma hepatocelular]]></kwd>
<kwd lng="pt"><![CDATA[Vírus da hepatite B]]></kwd>
<kwd lng="pt"><![CDATA[Metastização auricular]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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