<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2341-4545</journal-id>
<journal-title><![CDATA[GE-Portuguese Journal of Gastroenterology]]></journal-title>
<abbrev-journal-title><![CDATA[GE Port J Gastroenterol]]></abbrev-journal-title>
<issn>2341-4545</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Gastrenterologia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2341-45452025000400047</article-id>
<article-id pub-id-type="doi">10.1159/000541867</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Treat-to-Target in In&#64258;ammatory Bowel Disease: An Updated Survey of Treatment Strategies among Portuguese Gastroenterologists]]></article-title>
<article-title xml:lang="pt"><![CDATA[Treat-to-target na Doença In&#64258;amatória do intestino: uma atualização sobre as estratégias de tratamento entre gastrenterologistas portugueses]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[Diogo Couto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[Samuel Raimundo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bernardo]]></surname>
<given-names><![CDATA[Sónia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Correia]]></surname>
<given-names><![CDATA[Luís]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cortez-Pinto]]></surname>
<given-names><![CDATA[Helena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Magro]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidade Local de Saúde de Santa Maria Hospital Santa Maria Serviço de Gastrenterologia e Hepatologia]]></institution>
<addr-line><![CDATA[Lisbon ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade de Lisboa Faculdade de Medicina Clínica Universitária de Gastrenterologia]]></institution>
<addr-line><![CDATA[Lisbon ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Grupo de Estudos de Doença In&#64258;amatória do Intestino, GEDII  ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade do Porto Faculdade de Medicina CINTESIS@RISE]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2025</year>
</pub-date>
<volume>32</volume>
<numero>4</numero>
<fpage>47</fpage>
<lpage>54</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2341-45452025000400047&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2341-45452025000400047&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2341-45452025000400047&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background:  In 2018, the authors surveyed the clinical practices among Portuguese gastroenterologists (PGEs) regarding treatment targets in Crohn&#8217;s disease (CD) and ulcerative colitis (UC). Since then, new evidence has emerged supporting additional targets, such as transmural remission and histological remission. This study provides an updated assessment of treatment practices among PGE with special emphasis on these new targets.  Methods:  Using the Portuguese In&#64258;ammatory bowel disease Study Group (GEDII) physician database, we invited PGE to participate in an anonymous online survey.  Results:  Fifty-six physicians agreed to participate in the study. Deep remission, steroid-free clinical remission, endoscopic remission, and biomarker remission were ranked among the most important treatment targets in CD (89%, 80%, 89%, and 84%, respectively) and UC (82%, 84%, 79%, and 84%, respectively). In CD, transmural remission was considered a target by 70% of participants, with 48% agreeing to intensify treatment to achieve it. In UC, histological remission was aimed by only 45% of PGE with most (88%) being unwilling to intensify treatment to achieve this goal. Physicians were more likely to seek endoscopic remission in CD and UC in younger and healthier patients, compared to older patients with comorbidities.  Conclusion:  PGEs are increasingly pursuing tougher treatment targets such as transmural remission in CD and, to a lesser extent, histological remission in UC. Physicians are more willing to escalate treatment to achieve endoscopic remissioninyounger patients.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução:  em 2018, os autores realizaram um inquérito sobre as práticas clínicas entre gastrenterologistas portugueses (GEP) relativamente a alvos de tratamento na doença de Crohn (DC) e colite ulcerosa (CU). Desde então, surgiu evidência clínica a suportar novos alvos terapêuticos, como a remissão transmural e a remissão histológica. O presente estudo pretende fazer uma atualização das estratégias de tratamento praticadas entre GEP, com especial ênfase para estes novos alvos terapêuticos.  Métodos:  utilizando a base de dados de médicos do Grupo Português de Estudo da Doença In&#64258;amatória Intestinal (GEDII), convidamos GEP a participar num inquérito anónimo online.  Resultados:  56 médicos aceitaram participar no estudo. A remissão profunda, a remissão clínica livre de corticosteroides, a remissão endoscópica e a remissão de biomarcadores foram classi&#64257;cadas como os alvos de tratamento mais importantes na DC (89%, 80%, 89% e 84%, respetivamente) e na CU (82%, 84%, 79% e 84%, respetivamente). Na DC, a remissão transmural foi considerada um alvo terapêutico por 70% dos participantes, e 48% concordaram em intensi&#64257;car o tratamento para atingi-la. Na CU, a remissão histológica foi considerada um objetivo por apenas 45%dos GEP, sendo que a maioria (88%) revelou não estar disposta a intensi&#64257;car o tratamento para alcançá-lo. Os GEP tenderam a perseguir com maior frequência a remissão endoscópica, na DC e CU, em doentes mais jovens e saudáveis, comparativamente a doentes mais velhos e com comorbilidades.  Conclusão:  os GEP procuram de forma crescente perseguir alvos terapêuticos mais exigentes, como a remissão transmural na DC e, em menor grau, a remissão histológica na CU. Os clínicos parecem mais predispostos a intensi&#64257;car o tratamento para alcançar a remissão endoscópica em doentes mais jovens.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[In&#64258;ammatory bowel disease]]></kwd>
<kwd lng="en"><![CDATA[Transmural remission]]></kwd>
<kwd lng="en"><![CDATA[Histological remission]]></kwd>
<kwd lng="pt"><![CDATA[Doença in&#64258;amatória do intestino]]></kwd>
<kwd lng="pt"><![CDATA[Remissão transmural]]></kwd>
<kwd lng="pt"><![CDATA[Remissão histológica]]></kwd>
</kwd-group>
</article-meta>
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