<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2504-3145</journal-id>
<journal-title><![CDATA[Portuguese Journal of Public Health]]></journal-title>
<abbrev-journal-title><![CDATA[Port J Public Health]]></abbrev-journal-title>
<issn>2504-3145</issn>
<publisher>
<publisher-name><![CDATA[Escola Nacional de Saúde Pública]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2504-31452020000300151</article-id>
<article-id pub-id-type="doi">10.1159/000514925</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[COVID-19 and Its Symptoms&#8217; Panoply: A Case-Control Study of 919 Suspected Cases in Locked-Down Ovar, Portugal]]></article-title>
<article-title xml:lang="pt"><![CDATA[COVID-19 e a sua panóplia de sintomas: um estudo caso-controlo de 919 casos suspeitos durante o cordão sanitário de Ovar, Portugal]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sá]]></surname>
<given-names><![CDATA[Regina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pinho-Bandeira]]></surname>
<given-names><![CDATA[Tiago]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Queiroz]]></surname>
<given-names><![CDATA[Guilherme]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Matos]]></surname>
<given-names><![CDATA[Joana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[João Duarte]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodrigues]]></surname>
<given-names><![CDATA[Pedro Pereira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Baixo Vouga Primary Care Cluster Public Health Unit ]]></institution>
<addr-line><![CDATA[Aveiro ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,University of Porto Faculty of Medicine CINTESIS]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<volume>38</volume>
<numero>3</numero>
<fpage>151</fpage>
<lpage>158</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2504-31452020000300151&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2504-31452020000300151&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2504-31452020000300151&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background:  Ovar was the first Portuguese municipality to declare active community transmission of SARS-CoV-2, with total lockdown decreed on March 17, 2020. This context provided conditions for a large-scale testing strategy, allowing a referral system considering other symptoms besides the ones that were part of the case definition (fever, cough, and dyspnea). This study aims to identify other symptoms associated with COVID-19 since it may clarify the pre-test probability of the occurrence of the disease.  Methods:  This case-control study uses primary care registers between March 29 and May 10, 2020 in Ovar municipality. Pre-test clinical and exposure-risk characteristics, reported by physicians, were collected through a form, and linked with their laboratory result.  Results:  The study population included a total of 919 patients, of whom 226 (24.6%) were COVID-19 cases and 693 were negative for SARS-CoV-2. Only 27.1% of the patients reporting contact with a confirmed or suspected case tested positive. In the multivariate analysis, statistical significance was obtained for headaches (OR 0.558), odynophagia (OR 0.273), anosmia (OR 2.360), and other symptoms (OR 2.157). The interaction of anosmia and odynophagia appeared as possibly relevant with a borderline statistically significant OR of 3.375.  Conclusion:  COVID-19 has a wide range of symptoms. Of the myriad described, the present study highlights anosmia itself and calls for additional studies on the interaction between anosmia and odynophagia. Headaches and odynophagia by themselves are not associated with an increased risk for the disease. These findings may help clinicians in deciding when to test, especially when other diseases with similar symptoms are more prevalent, namely in winter.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução:  Ovar foi o primeiro município português a declarar transmissão comunitária ativa de SARS-CoV-2, determinando-se um cordão sanitário a 17 de março de 2020. Este contexto providenciou condições para a testagem em larga escala, permitindo um sistema de referenciação que abrangesse outros sintomas além dos que faziam parte da definição de caso (febre, tosse e dispneia). Este estudo tem como objetivo identificar outros sintomas associados à COVID-19, dado que pode esclarecer a probabilidade pré-teste de ocorrência da doença.  Métodos:  Este estudo caso-controlo utiliza registos dos cuidados de saúde primários entre 29 de março e 10 de maio de 2020, no município de Ovar. O quadro clínico e a exposição de risco, à apresentação, reportados por médicos através de um formulário, foram recolhidos e associados aos respetivos resultados laboratoriais.  Resultados:  A população do estudo incluiu um total de 919 doentes, dos quais 226 (24.6%) eram casos confimados de COVID-19 e 693 tiveram teste negativo para SARS-CoV-2. Apenas testaram positivo 27.1% dos doentes que reportaram contacto com um caso confirmado ou suspeito. Na análise multivariável, foi obtida significância estatística para cefaleias (OR 0.558), odinofagia (OR 0.273), anosmia (OR 2.360), e outros sintomas (OR 2.157). A combinação de anosmia e odinofagia surgiu como possivelmente relevante, no limite de significância estatística, e com um OR de 3.375.  Conclusão:  A COVID-19 tem um amplo espetro de sintomas. De entre todos os descritos, este estudo destaca a anosmia e revela a necessidade de estudos adicionais sobre a interação entre anosmia e odinofagia. Cefaleias e odinofagia por si só não estão associadas a um risco aumentado para a doença. Estes resultados podem ajudar a decisão clínica, especialmente quando outras doenças com sintomas semelhantes são mais prevalentes, nomeadamente no inverno.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[COVID-19SARS-CoV-2]]></kwd>
<kwd lng="en"><![CDATA[Anosmia]]></kwd>
<kwd lng="en"><![CDATA[Primary care]]></kwd>
<kwd lng="en"><![CDATA[Epidemiology]]></kwd>
<kwd lng="pt"><![CDATA[COVID-19]]></kwd>
<kwd lng="pt"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="pt"><![CDATA[Anosmia]]></kwd>
<kwd lng="pt"><![CDATA[Cuidados de saúde primários]]></kwd>
<kwd lng="pt"><![CDATA[Epidemiologia.]]></kwd>
</kwd-group>
</article-meta>
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