<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2795-5001</journal-id>
<journal-title><![CDATA[Portuguese Journal of Dermatology and Venereology]]></journal-title>
<abbrev-journal-title><![CDATA[Port J Dermatol Venereol.]]></abbrev-journal-title>
<issn>2795-5001</issn>
<publisher>
<publisher-name><![CDATA[Permanyer Publications]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2795-50012022000300188</article-id>
<article-id pub-id-type="doi">10.24875/pjdv.m22000042</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Isotretinoin treatment and risk of depression in acne vulgar patient: what is the evidence?]]></article-title>
<article-title xml:lang="pt"><![CDATA[O tratamento com isotretinoína e o risco de depressão em doentes com acne vulgar: qual a evidência?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[Diana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[Ana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Matos]]></surname>
<given-names><![CDATA[Maria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fertusinhos]]></surname>
<given-names><![CDATA[Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pendás]]></surname>
<given-names><![CDATA[Rosa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Administração Regional do Norte Unidade de Cuidados de Saúde Personalizados Chaves IB Medicina Geral e Familiar]]></institution>
<addr-line><![CDATA[Chaves ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Administração Regional do Norte Unidade de Saúde Familiar São Neutel Medicina Geral e Familiar]]></institution>
<addr-line><![CDATA[Chaves ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Unidade de Cuidados de Saúde Personalizados Chaves IB Medicina Geral e Familiar ]]></institution>
<addr-line><![CDATA[Chaves ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2022</year>
</pub-date>
<volume>80</volume>
<numero>3</numero>
<fpage>188</fpage>
<lpage>192</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2795-50012022000300188&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2795-50012022000300188&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2795-50012022000300188&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Acne vulgaris is a chronic inflammatory skin disease that often affects teenagers and young adults. The approach and treatment depend on the location, morphology, and severity of acne. Oral isotretinoin, used in the treatment of severe or refractory nodular acne, may be related to the development of psychiatric pathologies, such as depression or suicidal ideation. The aim of this review is to determine whether isotretinoin treatment is associated with the development of depression in patients with acne vulgaris.  Methods: A systematic review of scientific evidence published in electronic databases, using the MeSH terms isotretinoin, acne, and depression. The Strength of Recommendation Taxonomy Scale was used to assess the studies&#8217; quality and the recommendation&#8217;s strength.  Results: A total of 142 articles were identified and five met the inclusion criteria: two meta-analyses and three cohort studies (two prospective and one retrospective study).  Discussion: The risk of depression associated with taking isotretinoin by acne patients has been a concern and a controversial topic, however, the results are consensual in stating that there doesn&#8217;t seem to exist any evidence of this association. It was also found that acne treatment, regardless of drug, seems to improve depressive symptoms. The heterogeneity of the studies, the small sample size, and the absence of randomized clinical trials are some limitations. More studies are needed to confirm these findings.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução: A acne vulgar é a doença inflamatória crónica da pele, que afeta frequentemente adolescentes e adultos jovens. A abordagem e tratamento dependem da localização, morfologia e gravidade da acne. A isotretinoína oral, utilizada no tratamento da acne nodular grave ou refratário, pode estar relacionada com o desenvolvimento de patologia psiquiátrica, como depressão ou ideação suicida. Com esta revisão pretende-se determinar se o tratamento com isotretinoína está associado ao desenvolvimento de depressão em doentes com acne vulgar.  Métodos: Revisão sistemática da evidência científica publicada em bases de dados eletrónicas, utilizando os termos MeSH isotretinoin, acne, depression. Foi utilizada a escala Strength of Recommendation Taxonomy para avaliar a qualidade dos estudos e força de recomendação.  Resultados: Foram identificados 142 artigos, dos quais cinco cumpriram os critérios de inclusão: duas metanálises e três estudos de coorte (dois prospetivos e um retrospetivo).  Discussão: O risco de depressão associado à toma de isotretinoína por doentes com acne tem sido uma preocupação e um tema controverso, no entanto os resultados desta revisão são consensuais a afirmar que não parece existir evidência sobre essa associação. Verificou-se ainda que o tratamento daacne, independentemente do fármaco, parece melhorar os sintomas depressivos. A heterogeneidade dos estudos, o pequeno tamanho amostral e a ausência de ensaios clínicos aleatorizados são algumas das limitações. Mais estudos são necessários para confirmar estes achados.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Isotretinoin]]></kwd>
<kwd lng="en"><![CDATA[Acne]]></kwd>
<kwd lng="en"><![CDATA[Depression]]></kwd>
<kwd lng="pt"><![CDATA[Isotretinoína]]></kwd>
<kwd lng="pt"><![CDATA[Acne]]></kwd>
<kwd lng="pt"><![CDATA[Depressão]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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