<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2795-5001</journal-id>
<journal-title><![CDATA[Portuguese Journal of Dermatology and Venereology]]></journal-title>
<abbrev-journal-title><![CDATA[Port J Dermatol Venereol.]]></abbrev-journal-title>
<issn>2795-5001</issn>
<publisher>
<publisher-name><![CDATA[Permanyer Publications]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2795-50012022000300213</article-id>
<article-id pub-id-type="doi">10.24875/pjdv.m22000032</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Syphilitic hepatitis: a rare complication of secondary syphilis. A case report]]></article-title>
<article-title xml:lang="pt"><![CDATA[Hepatite sifilítica: uma complicação rara da sífilis secundária. O reporte de um caso]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Caldeira]]></surname>
<given-names><![CDATA[M. Brito]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[João]]></surname>
<given-names><![CDATA[A.L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pestana]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Canha]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Simões]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,E.P.E.&#8211;Alameda Santo António dos Capuchos Dermatology and Venereology Department ]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,E.P.E.&#8211;Alameda Santo António dos Capuchos Gastroenterology Department&#8211;Hospital de Santo António dos Capuchos&#8211;Centro Hospitalar Universitário de Lisboa Central ]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2022</year>
</pub-date>
<volume>80</volume>
<numero>3</numero>
<fpage>213</fpage>
<lpage>216</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2795-50012022000300213&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2795-50012022000300213&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2795-50012022000300213&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Syphilis is a sexually transmitted disease caused by Treponema pallidum, progressing through active and latent stages if left untreated. Hepatic involvement can occur in secondary syphilis, but this is an uncommon complication, with few published case reports. A 34-year-old man without significant medical history was admitted to the gastroenterology department with a 2-week history of unexplained jaundice and acute cholestatic hepatitis. He also presented with erythematous papules and plaques in the genital area, suggestive of secondary syphilis. T. pallidum hemaglutination assay and venereal disease research laboratory test were both positive, the latter with a 1:16 titer. The diagnosis of secondary syphilis with hepatic involvement was considered. The improvement of cutaneous and laboratory findings after intramuscular benzathine penicillin injection supported this hypothesis. Symptomatic cholestatic hepatitis is a rare feature of the systemic spectrum of secondary syphilis. The clinical and laboratorial response after penicillin treatment is a strong clue for this diagnosis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A sífilis é uma patologia de transmissão sexual causada pelo Treponema pallidum que, quando não tratada, evolui por períodos de atividade e latência. O envolvimento hepático pode ocorrer na sífilis secundária, sendo uma complicação rara, com poucos casos publicados. Um homem de 34 anos, previamente saudável, encontrava-se internado no serviço de Gastroenterologia para investigação de icterícia, hepatite e colestase inexplicadas, com cerca de 2 semanas de evolução. Adicionalmente, tinha placas eritemato-descamativas localizadas no pénis. A pesquisa de testes treponémicos e não-treponémicos foi positiva, pelo que se colocou a hipótese diagnóstica de sífilis secundária com envolvimento hepático. O tratamento com injeção intramuscular de penicilina benzatínica em dose única com subsequente melhoria dos achados cutâneos e laboratoriais corroborou a hipótese prévia. A hepatite sifilítica pode fazer parte do espectro da sífilis secundária. A melhoria clínica e laboratorial após o tratamento com penicilina é uma pista forte para este diagnóstico.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Syphilis]]></kwd>
<kwd lng="en"><![CDATA[Hepatitis]]></kwd>
<kwd lng="en"><![CDATA[Treponema pallidum]]></kwd>
<kwd lng="en"><![CDATA[Case report]]></kwd>
<kwd lng="pt"><![CDATA[Sífilis]]></kwd>
<kwd lng="pt"><![CDATA[Hepatite]]></kwd>
<kwd lng="pt"><![CDATA[Treponema pallidum]]></kwd>
<kwd lng="pt"><![CDATA[Case report]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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