<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2795-5001</journal-id>
<journal-title><![CDATA[Portuguese Journal of Dermatology and Venereology]]></journal-title>
<abbrev-journal-title><![CDATA[Port J Dermatol Venereol.]]></abbrev-journal-title>
<issn>2795-5001</issn>
<publisher>
<publisher-name><![CDATA[Permanyer Publications]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2795-50012024000300167</article-id>
<article-id pub-id-type="doi">10.24875/pjdv.24000039</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Use of metformin for the treatment of acne in the absence of polycystic ovarian syndrome: a literature review]]></article-title>
<article-title xml:lang="pt"><![CDATA[Uso da metformina no tratamento da acne na ausência de síndrome do ovário poliquístico: uma revisão da literatura]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jesus]]></surname>
<given-names><![CDATA[Ana M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[Ana S.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cunha-Santos]]></surname>
<given-names><![CDATA[Catarina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[Joana F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Freitas-Osório]]></surname>
<given-names><![CDATA[Mafalda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ribeiro-Almeida]]></surname>
<given-names><![CDATA[Sílvia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Andrade]]></surname>
<given-names><![CDATA[Jorge]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leal-Pinto]]></surname>
<given-names><![CDATA[Teresa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Coelho]]></surname>
<given-names><![CDATA[Jacinta]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bernardo]]></surname>
<given-names><![CDATA[Diana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidade Local de Saúde Santo António Unidade de Saúde Familiar Monte Crasto ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Unidade Local de Saúde Santo António Department of Dermatology ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<volume>82</volume>
<numero>3</numero>
<fpage>167</fpage>
<lpage>176</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2795-50012024000300167&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2795-50012024000300167&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2795-50012024000300167&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Acne is a chronic, inflammatory, multifactorial disorder of the pilosebaceous unit, with no associated mortality but often accompanied by high physical and psychological morbidity. Metformin is an antihyperglycemic drug under investigation as a therapeutic option for acne in adults and adolescents. The authors performed an evidence-based review, according to the population, intervention, control, and outcomes methodology, to assess whether there is evidence for the use of metformin (monotherapy or adjuvant) in the treatment of acne in adolescents and adults in the absence of polycystic ovary syndrome (PCOS). At the end of the review method, five original studies were eligible for this review. All studies showed a statistically significant improvement in acne lesions in patients receiving metformin. Despite the small number of articles included in this review, results suggest that the use of metformin for the management of acne can be an option, although further investigation is required. According to the current evidence, metformin could be a therapeutic option in the treatment of acne without PCOS, with strength of recommendation taxonomy B level of evidence. This treatment has shown clinical benefits, particularly in acne resistant to other therapies or in more severe acne cases, improving the number and severity of the lesions.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A acne é uma doença crónica, inflamatória e multifatorial da unidade pilossebácea, sem mortalidade associada, mas frequentemente acompanhada de alta morbilidade física e psicológica. A metformina, um antidiabético oral que diminui a glicemia, está a ser investigada como uma opção terapêutica no tratamento de acne em adultos e adolescentes. Os autores realizaram uma revisão baseada na evidência, de acordo com a metodologia PICO, com o objetivo de avaliar se existe evidência do uso da metformina (monoterapia ou adjuvante) no tratamento de acne em adultos e adolescentes na ausência de Síndrome do Ovário Poliquístico (SOP). No fim da pesquisa, cinco artigos originais foram considerados elegíveis para a revisão. Todos os estudos selecionados mostraram uma melhoria estatisticamente significativa nas lesões de acne nos pacientes que receberam metformina. Apesar do número reduzido de artigos incluídos na revisão, os resultados sugerem que a metformina pode ser utilizada como opção terapêutica na acne, embora seja necessária mais investigação. De acordo com a evidência atual, a metformina pode ser uma opção terapêutica no tratamento da acne sem SOP, com um nível de evidência B na SORT. Este tratamento demonstrou benefícios clínicos, particularmente na acne resistente a outros tratamentos ou em casos mais severos, melhorando o número e a gravidade das lesões.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Acne]]></kwd>
<kwd lng="en"><![CDATA[Acneiform eruptions]]></kwd>
<kwd lng="en"><![CDATA[Evidence-based medicine]]></kwd>
<kwd lng="en"><![CDATA[Metformin]]></kwd>
<kwd lng="en"><![CDATA[Treatment]]></kwd>
<kwd lng="pt"><![CDATA[Acne]]></kwd>
<kwd lng="pt"><![CDATA[Erupções acneiformes]]></kwd>
<kwd lng="pt"><![CDATA[Medicina baseada na evidência]]></kwd>
<kwd lng="pt"><![CDATA[Metformina]]></kwd>
<kwd lng="pt"><![CDATA[Tratamento]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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