<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2795-5001</journal-id>
<journal-title><![CDATA[Portuguese Journal of Dermatology and Venereology]]></journal-title>
<abbrev-journal-title><![CDATA[Port J Dermatol Venereol.]]></abbrev-journal-title>
<issn>2795-5001</issn>
<publisher>
<publisher-name><![CDATA[Permanyer Publications]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2795-50012025000200133</article-id>
<article-id pub-id-type="doi">10.24875/pjdv.24000086</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Terbinafine-induced generalized pustular psoriasis treated with dapsone]]></article-title>
<article-title xml:lang="pt"><![CDATA[Psoríase pustulosa generalizada secundária a terbinafina e tratada com dapsona]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Monteiro]]></surname>
<given-names><![CDATA[Matilde]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Matos]]></surname>
<given-names><![CDATA[Joana F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Coelho]]></surname>
<given-names><![CDATA[André]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Queirós]]></surname>
<given-names><![CDATA[Catarina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,EPE Unidade Local de Saúde de Gaia/Espinho Department of Dermatology]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,UNILABS Pathology ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>83</volume>
<numero>2</numero>
<fpage>133</fpage>
<lpage>138</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2795-50012025000200133&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2795-50012025000200133&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2795-50012025000200133&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract We report the case of a 37-year-old healthy woman who developed a generalized cutaneous eruption 1 week after starting oral terbinafine. The eruption was nonspecific, composed of erythematous&#8212;violaceous patches, limited areas of epidermal detachment, and sparse sterile pustules. Initial differential diagnoses included Stevens-Johnson Syndrome (SJS) and Acute Generalized Exanthematous Pustulosis (AGEP). Systemic corticosteroid therapy was initiated, with no improvement after 2 weeks. Skin biopsies suggested a diagnosis of pustular psoriasis,and during hospitalization, the patient developed scalyplaques on her scalp, more in keeping with terbinafine-induced Generalized Pustular Psoriasis (GPP). The patient was started on cyclosporine, which proved ineffective, followed by oral dapsone, which led toa major improvement within just 2 days. This case highlights the difficulty of differentiating between SJS, AGEP, and GPP in the presence of a nonspecific drug eruption and suggests dapsone as a safe therapeutic alternative for GPP.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo Descrevemos o caso de uma mulher de 37 anos, saudável,observada em contexto de urgência de Dermatologia por erupção cutânea generalizada 1 semana após o início de terbinafina oral. Clinicamente, objetivavam-se manchas eritematovioláceas, áreas limitadas de descolamento epidérmico e escassas pústulas estéreis. Foram inicialmente considerados os diagnósticos diferenciais de Síndrome de Stevens-Johnson (SSJ) e Pustulose Exantemática Generalizada Aguda (AGEP). Foi iniciada corticoterapia sistémica, sem melhoria após 2 semanas. O resultado da biópsia cutânea foi compatível com psoríase pustulosa e, durante o internamento, a doente desenvolveu lesões descamativas no couro cabeludo, estabelecendo-se assim o diagnóstico de Psoríase Pustulosa Generalizada (PPG) secundária a terbinafina. A doente iniciou ciclosporina, sem resposta, seguida de dapsona oral, com melhoria significativa em apenas 2 dias. Este caso realça a dificuldade do diagnóstico diferencial entre SSJ, AGEP e PPG perante um quadro pouco específico de toxidermia e propõe a dapsona como alternativa terapêutica segura na PPG.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Generalized pustular psoriasis]]></kwd>
<kwd lng="en"><![CDATA[Drug eruption]]></kwd>
<kwd lng="en"><![CDATA[Terbinafine]]></kwd>
<kwd lng="en"><![CDATA[Dapsone]]></kwd>
<kwd lng="pt"><![CDATA[Psoríase pustulosa generalizada]]></kwd>
<kwd lng="pt"><![CDATA[Toxidermia]]></kwd>
<kwd lng="pt"><![CDATA[Terbinafina]]></kwd>
<kwd lng="pt"><![CDATA[Dapsona]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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