<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2795-5001</journal-id>
<journal-title><![CDATA[Portuguese Journal of Dermatology and Venereology]]></journal-title>
<abbrev-journal-title><![CDATA[Port J Dermatol Venereol.]]></abbrev-journal-title>
<issn>2795-5001</issn>
<publisher>
<publisher-name><![CDATA[Permanyer Publications]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2795-50012026000100038</article-id>
<article-id pub-id-type="doi">10.24875/pjdv.25000047</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Eccrine spiradenoma: three case reports]]></article-title>
<article-title xml:lang="pt"><![CDATA[Espiroadenoma écrino: três casos clínicos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[Rafael B.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz]]></surname>
<given-names><![CDATA[Maria J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[Manuel B.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz]]></surname>
<given-names><![CDATA[Filipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Roberto P.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rios]]></surname>
<given-names><![CDATA[Elisabete]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leal]]></surname>
<given-names><![CDATA[Carolina A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Magalhães]]></surname>
<given-names><![CDATA[João M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bessa]]></surname>
<given-names><![CDATA[Maria H.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Department of Dermatology and Venereology Department of Dermatology and Venereology ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Department of General Surgery Department of General Surgery ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Unidade Local de Saúde de São João Department of Pathology ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2026</year>
</pub-date>
<volume>84</volume>
<numero>1</numero>
<fpage>38</fpage>
<lpage>41</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2795-50012026000100038&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2795-50012026000100038&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2795-50012026000100038&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Eccrine spiradenoma is a rare benign adnexal tumor, usually presenting as a painful solitary cutaneous nodule. We report three histologically confirmed cases in male patients aged 38 to 62 years, with lesions located on the right arm, forearm, and anterior hemithorax. Only one patient reported pain, underscoring the variability of clinical symptoms. All tumors exhibited the classic biphasic cell population and basement membrane material, without atypia or mitotic activity. Case 1 also demonstrated lymphoid infiltrates and vascular ectasias, with EMA-positive neoplastic epithelial cells. This series highlights uncommon demographic and anatomical presentations and reinforces the importance of histopathological evaluation for accurate diagnosis of eccrine spiradenoma, particularly in atypical settings.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo O espiroadenoma écrino é um tumor anexial benigno raro, que habitualmente se apresenta como um nódulo cutâneo solitário e doloroso. Descrevemos três casos histologicamente confirmados em homens entre os 38 e os 62 anos, com lesões no braço, antebraço e hemitórax anterior direitos. Apenas um dos doentes referiu dor, evidenciando a variabilidade clínica. Todos os tumores apresentavam a clássica população celular bifásica e material de membrana basal, sem atipia nem mitoses. O Caso 1 mostrou, ainda, infiltrado linfocitário e ectasias vasculares, com expressão de EMA nas células epiteliais neoplásicas. Esta série salienta apresentações demográficas e anatómicas invulgares, reforçando a importância da avaliação histopatológica no diagnóstico preciso de espiroadenomas écrinos, sobretudo em contextos atípicos.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Eccrine spiradenoma]]></kwd>
<kwd lng="en"><![CDATA[Adnexal tumor]]></kwd>
<kwd lng="en"><![CDATA[Skin nodule]]></kwd>
<kwd lng="en"><![CDATA[Histopathology]]></kwd>
<kwd lng="pt"><![CDATA[Espiroadenoma écrino]]></kwd>
<kwd lng="pt"><![CDATA[Tumor anexial]]></kwd>
<kwd lng="pt"><![CDATA[Nódulo cutâneo]]></kwd>
<kwd lng="pt"><![CDATA[Histopatologia]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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