<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2795-5001</journal-id>
<journal-title><![CDATA[Portuguese Journal of Dermatology and Venereology]]></journal-title>
<abbrev-journal-title><![CDATA[Port J Dermatol Venereol.]]></abbrev-journal-title>
<issn>2795-5001</issn>
<publisher>
<publisher-name><![CDATA[Permanyer Publications]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2795-50012026000100050</article-id>
<article-id pub-id-type="doi">10.24875/pjdv.25000079</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Angiosarcoma: clinical and histopathological characterization of five cases and literature review]]></article-title>
<article-title xml:lang="pt"><![CDATA[Angiossarcomas: caracterização clínica e histopatológica de cinco casos e revisão da literatura]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carvalho]]></surname>
<given-names><![CDATA[Mélissa Mendes-de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Coelho]]></surname>
<given-names><![CDATA[Margarida Valejo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Palmeiro]]></surname>
<given-names><![CDATA[Ana Gusmão]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Viana]]></surname>
<given-names><![CDATA[Isabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bajanca]]></surname>
<given-names><![CDATA[Rui]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidade Local de Saúde de Lisboa Ocidental Department of Dermatology and Venereology ]]></institution>
<addr-line><![CDATA[Lisbon ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2026</year>
</pub-date>
<volume>84</volume>
<numero>1</numero>
<fpage>50</fpage>
<lpage>55</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2795-50012026000100050&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2795-50012026000100050&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2795-50012026000100050&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Angiosarcomas are rare, aggressive endothelial tumors, accounting for &lt; 1% of all sarcomas. These tumors predominantly affect elderly Caucasian men and often occur on the face, scalp, or in areas of chronic lymphedema or previous radiotherapy exposure. Early diagnosis is essential due to their high recurrence and metastasis rates. This study aims to describe and analyze five cases of cutaneous angiosarcoma diagnosed at a tertiary hospital in Lisbon, highlighting clinical presentations and the importance of timely diagnosis. We reviewed five cases of cutaneous angiosarcoma diagnosed between 2014 and 2023 at a tertiary hospital. Data on demographics, clinical presentation, and tumor location were retrospectively collected and analyzed. The sample included five patients: three females and two males, with a mean age of 75.8 years. Lesions presented as erythematous and violaceous patches, plaques, and nodules across various anatomical sites. The findings emphasize the diversity of clinical presentations and underscore the need for a high index of suspicion among dermatologists. Due to the aggressive nature of angiosarcomas, dermatologists must maintain a high level of suspicion for early diagnosis, which can improve outcomes. In addition, there is an urgent need to develop novel therapeutic strategies to manage these tumors effectively.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo Os angiossarcomas são tumores endoteliais raros e agressivos, representando menos de 1% de todos os sarcomas. Estes tumores afetam predominantemente homens caucasianos idosos e surgem com maior frequência na face, couro cabeludo ou em áreas de linfedema crónico ou previamente expostas a radioterapia. O diagnóstico precoce é essencial devido às elevadas taxas de recidiva e metastização. Este estudo tem como objetivo descrever e analisar cinco casos de angiossarcoma cutâneo diagnosticados num hospital terciário em Lisboa, destacando a apresentação clínica e a importância de um diagnóstico atempado. Foram revistos cinco casos de angiossarcoma cutâneo diagnosticados entre 2014 e 2023 num hospital terciário. Recolheram-se e analisaram-se retrospetivamente dados demográficos, apresentação clínica e localização tumoral. A amostra incluiu cinco doentes: três do sexo feminino e dois do sexo masculino, com uma idade média de 75,8 anos. As lesões apresentaram-se sob a forma de máculas e placas eritematosas e violáceas, bem como nódulos, distribuídos por diferentes localizações anatómicas. Os resultados evidenciam a diversidade das apresentações clínicas e salientam a necessidade de um elevado índice de suspeição por parte dos Dermatologistas. Devido ao comportamento agressivo dos angiossarcomas, é fundamental que os Dermatologistas mantenham um elevado grau de suspeição para permitir um diagnóstico precoce, o que pode melhorar o prognóstico. Além disso, existe uma necessidade urgente de desenvolver novas estratégias terapêuticas para um tratamento mais eficaz destes tumores.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Cutaneous angiosarcomas]]></kwd>
<kwd lng="en"><![CDATA[Endothelial tumors]]></kwd>
<kwd lng="en"><![CDATA[Sarcomas]]></kwd>
<kwd lng="pt"><![CDATA[Angiossarcomas cutâneos]]></kwd>
<kwd lng="pt"><![CDATA[Tumores endoteliais]]></kwd>
<kwd lng="pt"><![CDATA[Sarcomas]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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