<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2795-5001</journal-id>
<journal-title><![CDATA[Portuguese Journal of Dermatology and Venereology]]></journal-title>
<abbrev-journal-title><![CDATA[Port J Dermatol Venereol.]]></abbrev-journal-title>
<issn>2795-5001</issn>
<publisher>
<publisher-name><![CDATA[Permanyer Publications]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2795-50012026000100059</article-id>
<article-id pub-id-type="doi">10.24875/pjdv.25000074</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Mycophenolate mofetil in refractory discoid lupus erythematosus. Case report and literature review]]></article-title>
<article-title xml:lang="pt"><![CDATA[Micofenolato de mofetil no lúpus eritematoso discoide refratário. Relato de um caso e revisão da literatura]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nogueira]]></surname>
<given-names><![CDATA[Carlos M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Joana S.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cerqueira]]></surname>
<given-names><![CDATA[Catarina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[Miguel S.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[Sofia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Brito]]></surname>
<given-names><![CDATA[Celeste]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Department of Dermatovenereology Department of Dermatovenereology ]]></institution>
<addr-line><![CDATA[Braga ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Unidade Local de Saúde de Braga Department of Pathology ]]></institution>
<addr-line><![CDATA[Braga ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2026</year>
</pub-date>
<volume>84</volume>
<numero>1</numero>
<fpage>59</fpage>
<lpage>63</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2795-50012026000100059&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2795-50012026000100059&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2795-50012026000100059&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Discoid lupus erythematosus (DLE) is a chronic autoimmune disease affecting the skin, often leading to scarring, dyspigmentation, and reduced quality of life. Although several first-line therapies are available, some cases remain refractory. We report a 53-year-old female with treatment-resistant DLE, presenting with cicatricial alopecia and plaques on the face, torso, and limbs. Histopathology confirmed the diagnosis. Conventional therapies &#8211; including corticosteroids, hydroxychloroquine, prednisolone, methotrexate, acitretin, and dapsone &#8211; failed to provide lasting control. Treatment with mycophenolate mofetil (MMF) achieved significant clinical improvement and stabilization over 15 months, with good tolerability. This case illustrates the challenges of managing refractory DLE and suggests MMF as a potential therapeutic option. A literature review reveals limited yet encouraging evidence from retrospective studies and case reports supporting MMF&#8217;s efficacy in refractory DLE. Further scientific evidence is needed to establish its role in clinical practice and guide treatment for patients with severe or treatment-resistant DLE.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo O Lúpus Eritematoso Discóide (LED) é uma dermatose autoimune crónica que causa alterações cicatriciais e redução da qualidade de vida. Apesar das terapêuticas de primeira linha disponíveis, alguns casos mantém-se refratários. Apresentamos o caso de uma mulher, 53 anos, com alopécia cicatricial e placas no rosto, tronco e membros. O exame histopatológico confirmou o diagnóstico de LED. Tratamentos prévios &#8211; incluindo corticosteroides tópicos, hidroxicloroquina, prednisolona oral, metotrexato, acitretina e dapsona &#8211; não permitiram controlo da dermatose. O tratamento com micofenolato de mofetil (MMF) resultou numa melhoria significativa e estabilização das lesões durante 15 meses, com boa tolerabilidade. Este caso ilustra os desafios na abordagem do LED refratário e sugere o MMF como opção terapêutica. Uma revisão da literatura revelou evidência limitada mas encorajadora, com base em estudos retrospectivos e relatos de caso. É necessária mais evidência científica para clarificar o papel do MMF e criar recomendações terapêuticas para doentes com LED grave/refratário.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Discoid lupus erythematosus]]></kwd>
<kwd lng="en"><![CDATA[Refractory cutaneous lupus]]></kwd>
<kwd lng="en"><![CDATA[Mycophenolate mofetil]]></kwd>
<kwd lng="en"><![CDATA[Autoimmune skin disease]]></kwd>
<kwd lng="en"><![CDATA[Cicatricial alopecia]]></kwd>
<kwd lng="en"><![CDATA[Immunosuppressive therapy]]></kwd>
<kwd lng="pt"><![CDATA[Lúpus eritematoso discoid]]></kwd>
<kwd lng="pt"><![CDATA[Lúpus cutâneo refratário]]></kwd>
<kwd lng="pt"><![CDATA[Micofenolato de mofetil]]></kwd>
<kwd lng="pt"><![CDATA[Doenças autoimunes]]></kwd>
<kwd lng="pt"><![CDATA[Alopécia cicatricial]]></kwd>
<kwd lng="pt"><![CDATA[Tratamento imunossupressor]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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