<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2976-0526</journal-id>
<journal-title><![CDATA[Portuguese Kidney Journal (PKJ)]]></journal-title>
<abbrev-journal-title><![CDATA[PKJ]]></abbrev-journal-title>
<issn>2976-0526</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Nefrologia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2976-05262025000100008</article-id>
<article-id pub-id-type="doi">10.71749/pkj.92</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[ANCA Renal Risk Score in a Portuguese Cohort: Insights and Comparison with Berden Classification]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pinto]]></surname>
<given-names><![CDATA[Raquel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Grilo]]></surname>
<given-names><![CDATA[João]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Luz]]></surname>
<given-names><![CDATA[Ivan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Andreia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lemos]]></surname>
<given-names><![CDATA[Sérgio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Góis]]></surname>
<given-names><![CDATA[Mário]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Viana]]></surname>
<given-names><![CDATA[Helena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidade Local de Saúde Viseu Dão-Lafões  ]]></institution>
<addr-line><![CDATA[Viseu ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Unidade Local de Saúde de Castelo Branco  ]]></institution>
<addr-line><![CDATA[Castelo Branco ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Unidade Local de Saúde do Médio Tejo  ]]></institution>
<addr-line><![CDATA[Torres Novas ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Unidade Local de Saúde São José  ]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<volume>39</volume>
<numero>1</numero>
<fpage>8</fpage>
<lpage>12</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2976-05262025000100008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2976-05262025000100008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2976-05262025000100008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  Antineutrophil cytoplasmic antibody (ANCA) &#8209;associated vasculitis (AAV) is a rare cause of glomerulonephritis. Despite advances in immunosuppressive therapies, AAV with renal involvement often leads to poor renal outcomes and a high&#8209;risk of end&#8209;stage renal disease (ESRD). Berden classification categorizes renal histology in four classes, but performance varies across cohorts. A lack of precise findings of prognostic value led to development of ANCA Renal Risk Score (ARRS). We assessed ARRS predictive value for renal survival in a Portuguese cohort and compared it to Berden classification.  Methods:  Observational and retrospective study analysing cases from native AAV kidney biopsies at a Portuguese histomorphology centre (2004&#8209;2023). Demographical data, percentage of normal glomeruli, interstitial fibrosis/tubular atrophy and estimated glomerular filtration rate (eGFR) were recorded. Samples were categorized by Berden class and ARRS. Descriptive and comparative analyses were performed.  Results:  One hundred fifty eight patients, 53.8 % male, with mean age of 67.1 ± 14.1 years. Median ARRS was 6.5 ± 3.6, with 10.8%, 44.3% and 44.9% being low, intermediate, and high&#8209;risk, respectively. Overall mean time to dialysis was 20 months, renal survival at 36 months was 92.9%, 63.6% and 29.7% in low, intermediate and high&#8209;risk groups. Patient survival did not differ between groups. ROC curves showed statistical significance for both scores, with ARRS having the highest AUC (AUC &lt;0.72, p&lt;0.001 vs 0.65, p=0.03).  Conclusion:  ARRS was effective in predicting renal survival in this cohort, outperforming Berden classification in deter-mining progression to ESRD at 36 months. Incorporating serum creatinine, treatment modalities and patient comorbidities could further improve ARRS predictive value.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Anti&#8209;Neutrophil Cytoplasmic Antibody&#8209;Associated Vasculitis]]></kwd>
<kwd lng="en"><![CDATA[Antibodies, Antineutrophil Cytoplasmic]]></kwd>
<kwd lng="en"><![CDATA[Glomerulonephritis]]></kwd>
<kwd lng="en"><![CDATA[Kidney Failure, Chronic]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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