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Portuguese Journal of Nephrology & Hypertension

Print version ISSN 0872-0169


SILVA, Rita M. et al. Early Antibody-Mediated Kidney Transplant Rejection: A Successful Case Without Donor-Specific Anti-HLA Antibodies. Port J Nephrol Hypert [online]. 2023, vol.37, n.2, pp.89-92.  Epub June 30, 2023. ISSN 0872-0169.

The diagnosis of antibody-mediated rejection has become more common and represents a major cause of kidney graft loss. The ideal treatment remains unknown, with little evidence supporting the use of a specific therapy. The definition of antibody-mediated rejection is based on serologic (presence and/or development of donor-specific antibodies) and histologic (evidence of acute tissue injury with C4d deposition or other signs of antibody interaction with the vascular endothelium) criteria. Antibody-mediated rejection without donor‐specific antibodies is a subcategory with a defying diagnosis. This particularly entity is increasingly being reported as an important cause of allograft dysfunction in kidney transplantation. We describe the case of a kidney transplant recipient with a low immunological risk and delayed graft function due to an antibody-mediated rejection with negative donor-specific antibodies.

Keywords : Graft Rejection/immunology; Histocompatibility/immunology; HLA Antigens/immunology; Isoantibodies/immunology; Kidney Transplantation.

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