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Jornal Português de Gastrenterologia

versão impressa ISSN 0872-8178


SANTOS, Liliana et al. Peginterferon_2-a in HBV − HVD coinfection: A case of double therapeutic success. J Port Gastrenterol. [online]. 2012, vol.19, n.3, pp.151-155. ISSN 0872-8178.

Hepatitis D virus (HDV) is a satellite virus which needs hepatitis B virus (HBV) for its replication. In most cases, HDV suppresses HBV replication and in these circumstances the treatment should be with Interferon. In patients that have no virological response after the 1th year of therapy, continuing it will possible increase the virological response and the loss of the HBs antigen. Case report: 42 years old man with chronic HBV, anti-HBe positive and low HBV viral load. He had increased transaminases which had persisted even after HBV-DNA negativation. We performed antibody anti-HDV that came positive and treated the patient with PegInterferon α-2ª during 102 weeks. We assist to normalization of the transaminases at week 33 and negativation of IgM-HVD at week 88. At the end of the treatment RNA-HDV was negative and the patient lost HBs antigen that persisted over the next sixth months. Comments: This case illustrates the importance of maintaining treatment until HDV virological response since the cure of the HDV may be accompanied by the cure of HBV infection.

Palavras-chave : Coinfection; HBV; HDV; Peginterferon.

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