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Revista de Enfermagem Referência
Print version ISSN 0874-0283On-line version ISSN 2182-2883
Abstract
LEITE, Viviane Vasconcelos et al. Wound healing: In vitro effects of the pharmacotherapeutic use of sunflower oil (Helianthus annuus). Rev. Enf. Ref. [online]. 2022, vol.serVI, n.1, e22026. Epub Mar 13, 2023. ISSN 0874-0283. https://doi.org/10.12707/rvi22026.
Background:
Vegetable oils have antimicrobial activity and promote cell proliferation. Sunflower oil is used as an alternative for treating skin wounds, particularly in underdeveloped or developing countries.
Objective:
To characterize sunflower oil and evaluate the in vitro effects on cell proliferation and antimicrobial activity.
Methodology:
The study was carried out using gas chromatography-mass spectrometry (GC-MS) analysis and cell proliferation and antimicrobial activity tests.
Results:
The chromatographic analysis identified the main components of sunflower oil, namely: unsaturated fatty acids (82.2%) with linoleic (47.8%), oleic (28.7%), and linolenic (3.9%) acids as the main lipids, followed by saturated (12.70%), palmitic (8.8%) and stearic (3.6%) acids. A difference (p < 0.001) in cell proliferation was found between treatments with sunflower oil (100 and 10 µg/ml) and the negative controls. It failed in antimicrobial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, and Klebsiella pneumoniae.
Conclusion:
Sunflower oil contains a high concentration of essential fatty acids and promotes cell proliferation but fails to inhibit bacterial activity.
Keywords : sunflower oil; wound healing; cell proliferation; antimicrobial; in vitro techniques.